
Originally Posted by
NewBreed
If you use IGF-1 you have a negative response on your gh secretion which will lead to a depletion of your natural gh-levels.
Due to high IGF-1 levels there will be e secretion of somatostatin,which causes the inhibition of gh.
Gh also prepares the cells for the IGF-1,it leads the cell to the 1st step of mitosis,IGF-1 makes it complete.
That´s because IGF-1 is only beneficial during the first months,without exogenous gh,because without gh the cells lose their response to IGFs.