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  1. Dr Mariano briefly on suboptimal Thyroid numbers - T4, T3, TSH

    by , 11-10-2012 at 01:18 AM
    http://www.definitivemind.com/2009/0...nsplease-help/

    A Total T4 is crucial to obtain since it gives me an idea of how much thyroid hormone a person may need. The other values only give me an idea of how the other systems interact with thyroid hormone. For example, if the brain is healthy enough to produce TSH, then TSH tells me how much of a thyroid hormone deficit it is running.

    From a behavioral point of view (not an endocrinologist ...
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  2. Dr Mariano posts - nutrition, testosterone, depression

    by , 09-10-2012 at 06:07 PM
    http://www.definitivemind.com/forums...ead.php?t=1134

    Once Testosterone is in a good range, then any problems that are left have other causes.

    A lack of testosterone is often not sufficient to explain all symptoms a person with mental issues has. Generally, when a person develops mental problems, one is dealing with a multisystem problem.

    Adding testosterone does not often improve a person's ability to function if there are more important problems ...
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  3. Dr Mariano posts - l dopa, dopamine

    by , 09-10-2012 at 05:32 PM
    http://www.definitivemind.com/forums...read.php?t=591


    Velvet bean (Mucuna pruriens) is a tropical medicinal plant that is a member of the legume (bean) family. The bean of the plant contains a substantial amount of L-dopa, the precursor to dopamine (7-10% of the beans is L-dopa). Serotonin can be found in the bean pod, leaf and fruit. The bean contains numerous other substances which may be also active in affecting the nervous system. Because of these properties, I doubt ...
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  4. Dr Mariano posts - dopamine, Bupropion

    by , 09-10-2012 at 04:43 PM
    http://www.definitivemind.com/forums...read.php?t=173



    Dopamine agonists are useful to a certain extent.

    They are useful, for example, in conditions with suboptimal dopamine signaling, such as restless legs syndrome or Parkinsonism.

    Dopamine is the primary signal for libido. Thus, when other signals are optimized, yet dopamine signaling is still low, then Dopamine may be added to try and improve functioning.

    The problem ...
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  5. Dr Mariano posts - stimulants, Methylphenidate

    by , 09-10-2012 at 04:14 PM
    http://www.definitivemind.com/forums...ead.php?t=1157


    Stimulants always increase inflammation. Stimulants increase norepinephrine signaling, the primary signal for stress. This then signals the immune system cells of the body - including the brain's microglia - to enter a pro-inflammatory state to help protect the body. The primary problem is that the increase in pro-inflammatory signaling, particularly if there already is an increase or if it is in excess of what the ...
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