The truth about ibuprophen??

[cache49]

Ive posted this thread on two boards, so i appoligise to those who read it twice. There seems to be as many opinions about this as there is guys in the gym. Id like to see what this board thinks. How does ibuprophen use affect muscle gain, if at all? Thanx

[Johny-too-small]

NSAids can hinder gains.

[cache49]

Sorry for the newb question but what is NS? Dont know all the abreviations yet. ha ha.

[Johny-too-small]

nervous system

[cache49]

Thanx JTS

[Prada]

nervous system

Ibuprofen is a Non Steroidal Anti-Inflammatory Drug (NSAIDs).

[Dizz28]

Neither drug had any influence on whole body protein breakdown, as
measured by rate of phenylalanine appearance, on serum
creatine kinase, or on rating of perceived muscle soreness
compared with PLA. These results suggest that over-thecounter
doses of both ibuprofen and acetaminophen suppress
the protein synthesis response in skeletal muscle after eccentric
resistance exercise

Ibuprofen and acetaminophen are purported to relieve
muscle soreness and pain through separate mechanisms.
Ibuprofen is known to block cyclooxgenase (EC
1.14.99.1), which then reduces metabolites produced by
this enzyme, such as prostaglandins, that are at least
partially responsible for inflammation and algesia (14,
35, 36). However, prostaglandins have also been shown
to regulate protein metabolism, and NSAIDs similar to
ibuprofen have been shown to blunt protein metabolism
in animal skeletal muscle (24, 30). Therefore,
skeletal muscle protein metabolism may be influenced
in individuals who consume ibuprofen after unaccustomed
exercise. The mechanism of analgesic action of
acetaminophen, also known as paracetamol, is less
clear; however, it is believed to have its analgesic
action within the central nervous system (8, 11, 15, 32,
36). Thus acetaminophen would not be expected to
interfere with muscle protein metabolism after exercise.

......However, long-term use of
these drugs may inhibit the normal hypertrophic response
to resistance training. Future studies on the
impact of chronic consumption of over-the-counter
doses of these drugs on skeletal muscle are warranted.

[cache49]

great explanation. Thanx. Im not a chronic user by any means, only recomended doses, maybe a few times a week. Food for thought, thank u.

[eddy tye]

so basicly,

is it ok if your bodybuilding to take ibuprophen,if so when is enough...

[Dizz28]

so basicly,

is it ok if your bodybuilding to take ibuprophen,if so when is enough...

No, it's not good...read the first and last paragraph.

They basically state that it doesn't cause the breakdown of muscle...it just hinders the protien synthesis that creats more muscle...makes it difficult to gain muscle mass..