Article about the Exercise Hormone : Irisin

[RaginCajun]

I like to keep browse around searching for new information and stumbled upon some articles about Irisin, the so called 'exercise' hormone.

Nova, have you ran across this hormone in your teachings/classes?

Irisin: The magic exercise hormone? - The Eating Academy | Peter Attia, M.D. The Eating Academy | Peter Attia, M.D.

http://www.sciencedaily.com/releases...0813130018.htm

[ghettoboyd]

interesting article to read brother thanks...

[novastepp]

I like to keep browse around searching for new information and stumbled upon some articles about Irisin, the so called 'exercise' hormone.

Nova, have you ran across this hormone in your teachings/classes?

Irisin: The magic exercise hormone? - The Eating Academy | Peter Attia, M.D. The Eating Academy | Peter Attia, M.D.

http://www.sciencedaily.com/releases...0813130018.htm

I have not. It appears the clinical trials have yet to produce any conclusive results for humans...but that may be forthcoming. Interesting read and interesting topic for sure. Thanks.

[RaginCajun]

I have not. It appears the clinical trials have yet to produce any conclusive results for humans...but that may be forthcoming. Interesting read and interesting topic for sure. Thanks.

another good article on irisin

PLOS ONE: Endurance Training-Induced Increase in Circulating Irisin Levels Is Associated with Reduction of Abdominal Visceral Fat in Middle-Aged and Older Adults

[Splifton]

I have not. It appears the clinical trials have yet to produce any conclusive results for humans...but that may be forthcoming. Interesting read and interesting topic for sure. Thanks.

Here yeah go...

Cell Metab. 2015 Oct 6;22(4):734-40. doi: 10.1016/j.cmet.2015.08.001. Epub 2015 Aug 13.
Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry.
Jedrychowski MP1, Wrann CD2, Paulo JA3, Gerber KK2, Szpyt J3, Robinson MM4, Nair KS4, Gygi SP5, Spiegelman BM6.

Abstract

Exercise provides many health benefits, including improved metabolism, cardiovascular health, and cognition. We have shown previously that FNDC5, a type I transmembrane protein, and its circulating form, irisin, convey some of these benefits in mice. However, recent reports questioned the existence of circulating human irisin both because human FNDC5 has a non-canonical ATA translation start and because of claims that many human irisin antibodies used in commercial ELISA kits lack required specificity. In this paper we have identified and quantitated human irisin in plasma using mass spectrometry with control peptides enriched with heavy stable isotopes as internal standards. This precise state-of-the-art method shows that human irisin is mainly translated from its non-canonical start codon and circulates at ∼3.6 ng/ml in sedentary individuals; this level is increased to ∼4.3 ng/ml in individuals undergoing aerobic interval training. These data unequivocally demonstrate that human irisin exists, circulates, and is regulated by exercise.

https://www.ncbi.nlm.nih.gov/pubmed/26278051

I don't know if you guys can see the full study, but it's kind of an "ehhhh" feeling when I read it. It's apart of a highly complex category from what I'm getting (tertiary structuring). It's really a theoretical practice in biochemistry and molecular biology with how they went about with chosen isoforms.