Originally Posted by
peachfuzz
Therapeutic dose (20, 40 and 80 micrograms/man) of clenbuterol hydrochloride, a beta 2-adrenergic stimulant, was orally administered to healthy volunteers, and the unmetabolized drug in plasma and urine was determined by enzyme immunoassay. The plasma levels of clenbuterol reached the maximum value of 0.1, 0.2 and 0.35 ng/ml, respectively, in a dose-dependent manner within 2.5 h, which lasted for over 6 h after the administration. The half-life of clenbuterol in plasma was estimated to be about 35 h. When the drug was orally administered repeatedly to men twice a day, the plasma level reached the plateau within 4 d after the initial administration. At that time, the plasma levels of the unchanged form were 0.2 to 0.3 ng/ml and 0.5 to 0.6 ng/ml at doses of 20 and 40 micrograms/man, respectively. The bound ratio of the drug to plasma protein was estimated to be 89-98% at a single administration of 80 micrograms of the drug. The cumulative urinary excretion of unchanged compound corresponded to about 20% of the administered dose as measured at 72 h following a single oral administration.
this is why ive believed the 2 day on 2 day off dosing schedule to be ineffective. your never really taking a break from the clen, it seems to me like you are running lower doses longer. more of a steady ramp up as opposed to the relatively quick jump most make. thus making sides more tolerable. just my 2 cents. have you tried both protocols? if so, which one produced better results in terms of fat loss?
also is beta 2 downregulation dose dependent? or is duration more of a factor. if it is the former than i can see this working out relatively well.
Run CLEN without harsh sides
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