Ok, I am making a formal retraction and recanting my earlier belief about steriod use and the law and its health risks. I have done a great deal of reading and research since my post that I stated steroid laws are good. I now see the other side of things and changed my belief. I only did this after much study and sole searching. Here is a great article on the health risk of steriod use. Sources at the end.
BTW my fingers are really sore from typing all this in I hope a few members enjoy reading it and find it a good read. I had to split it up in 2 post.
Healthrisks of Steroid Use
Evaluating the Real Health Risks of Anabolic Steroids
A Few Words about Anabolic Steroid Research
Anabolic Steroid Use by Women and Teenagers
Adverse Effects of Excess Androgens
Anabolic Steroids and the Liver
Anabolic Steroids and the Heart
Anabolic Steroids and the Prostate
Anabolic Steroids and Aggressive/Psychiatric Symptoms
Anabolic Steroids and Psychological Dependence
Other Adverse Effects of Anabolic Steroids
The Dangers of Counterfeit Steroids
Conclusion
(Note: References sources in this section are provided at its end)
Evaluating the Real Health Risks of Anabolic Steroids
While the primary objective of Congress in classifying anabolic steroids as controlled substances (and criminalizing their use) was probably to solve the pharmacologic "cheating" problem in competition sports, the reported health risks associated with these "deadly drugs" provided a seemingly valid basis for the legislation. The reportedly devastating health hazards were used to justify a policy favoring imprisonment of athletes involved with steroids over allowing them to "destroy themselves" with these substances. But would such a policy be appropriate if the real health dangers to healthy adult males were actually significantly less than the members of Congress - and the general public - have been led to believe? An unbiased review of the medical and scientific evidence of risks to healthy adult males is necessary in order to understand and assess the legitimacy of our current national approach to the "steroid problem."
Regrettably, the medical and scientific community has historically been less than truthful in presenting information about anabolic steroids to the general public. For example, for many years their position was that steroids do not build muscle. (For an interesting examination of how study results were engineered to show that steroids do not work through the use of intentionally flawed designs, see, Taylor, 1982, pp. 16-19.) Even as late as 1984, in the highly publicized anti-steroid book Death in the Locker Room: Steroids&Sports (Goldman, 1984), then-medical student Bob Goldman seriously presented his theory about how steroids work in a subchapter devoted to the "placebo effect." It is unclear whether such faulty opinions were based upon ignorance of the overwhelming anecdotal evidence or upon an attempt to protect the public by concealing the truth. Whatever the reason, "[t]he medical community lost much credibility as a result of repeated denials that [steroids] enhance performance" (Yesalis, Kennedy, et al., 1993, p. 1217). Of course, the athletes themselves knew decades earlier about the dramatic effects of anabolics on sports performance and appearance. While today the medical establishment concedes that there is no doubt that anabolic steroids do indeed work (perhaps too well), its previous position created a tremendous distrust within the athletic community and led to an often recognized polarization between the groups which may never be undone.
Regarding anabolic steroid side effects and health hazards, the position of the medical community has been mostly linked to hyperbolic, hysterical works like Death in the Locker Room. The mainstream media, always seeking the sensationalism of a "big story," conveyed such material to the public as if it were gospel truth. With no personal experience to the contrary, the average American accepts this characterization of steroids as dangerous killer drugs. On the other hand, many strength athletes are convinced that doctors and the government advance the "side effect" argument mostly as a scare tactic to preserve the "purity" of athletic competition. They have amassed their own body of underground anecdotal evidence derived from their observations of side effects on themselves and on their peers, or from "underground" treatises on self-administration of steroids. "Athletes using anabolic steroids today have a sophisticated pharmacologic knowledge base for using these agents that surpasses that of the vast majority of physicians. For this reason, traditional warnings regarding the lack of efficacy and the potential dangers of steroid abuse are universally held in contempt. Today, it appears that the experts on anabolic steroid use in athletic competition are not medical clinicians but the athletes [themselves]" (Perry, et al., 1990, p. 422).
A Few Words about Anabolic Steroid Research
Several problems have affected much of the past research into anabolic steroid effects. Until very recently, it was considered unethical for researchers to administer the highly supraphysiologic dosages necessary to simulate use patterns of established steroid users. Therefore, most human studies involved steroid users self-reporting their histories of dosages and duration of use, rather than any controlled administration by the researchers. The reliability problems with this methodology have been noted by experts in the field. Only recently have researchers begun to administer more substantial dosages for short-term periods, simulating the moderate-dose steroid cycles used by some athletes (see, for example: Bhasin, et al., 1996; Hengge et al., 1996).
Another problem plaguing steroid research has been lack of funding. However, the growing interest in anabolic steroids for anti-aging and AIDS therapies may prompt grants for further research. Perhaps the most enlightening research would be retrospective cohort studies examining the health condition, cancer prevalence and mortality statistics of professional bodybuilders from the 1950's, 1960's and 1970's. With such studies, the long-term health ramifications of steroid use finally would be known and quantified. Regrettably, grant proposals to conduct such studies have been repeatedly turned down. Of course, a finding that there are generally no statistically significant long-term adverse effects (especially with moderate dosages and intermittent use) could encourage or increase non-medical steroid use, and might call into question our present national policy of criminalizing steroid users. Consequently, it is unlikely that a strong anti-steroid authority like the National Institute on Drug Abuse, a frequent sponsor of steroid research, will ever approve or fund such a study.
Anabolic Steroid Use by Women and Teenagers
Without question, there are health risks involved in the self-administration of any prescription medicine, particularly in the absence of a physician's advice with respect to dosages and duration of use. Further, without regular monitoring by a doctor, some side effects may go unnoticed or untreated until it is too late. Anabolic steroids can have adverse effects upon the body, and the risks for teenagers and women are higher than for adult males. Since large exogenous doses of androgens are more foreign to a woman's body than to a man's, their effect on the delicate hormonal balance of a woman is more profound. Excessive growth of body hair (hirsutism), coarsening of the skin, male pattern baldness, and deepening of the voice may occur (especially at massive dosages) and are generally not reversible upon discontinuance of steroids. Other possible effects particular to women include heavy facial masculinization, breast tissue reduction, alterations in menstrual cycles, and clitoral enlargement. Legal issues aside, any woman considering the use of high-dose androgens for physical enhancement must seriously weigh the perceived benefits against the quite unappealing potential cosmetic costs.
For teenagers, there is the additional risk of premature closure of the growth plates of the long bones. Even if not for this added risk, the self-administration of anabolics by teenagers must be strongly discouraged. As compared to mature adults, teenagers are much more likely to abuse anabolic steroids to the possible detriment of their health. Generally less focused upon long-range health than adults, more susceptible to peer pressure, and eager for fast results, teenagers are more likely to use anabolics in dangerously high dosages and without any medical supervision. Also, as it is recognized that the effects of anabolics upon size and strength are partially (and sometimes even completely) temporary, teens seem particularly less willing to suffer these post-cycle size and strength reductions, and are more likely to continuously use high-dose steroids for prolonged periods. Even Dan Duchaine, author of the Underground Steroid Handbook II (1989) and a favorite target of the proponents of steroid criminalization, is opposed to steroid use by teenagers. Clearly, even in countries where steroids can be legally obtained without a prescription, it is this writer's opinion that the choice to use them for physical enhancement should be made by mature, informed adults with a pre-established dedication to serious weight-training for several years. Anabolic steroids should never be used by beginning lifters, those with dubious commitments to weight-training, or those simply seeking a substitute for hard work. Parents with suspicions or concerns about their teen children experimenting with anabolics should see Wright&Cowart (1990), Chapter 4, "Recognizing Anabolic Steroid Use in Adolescents," pp. 71 -91. [But as strongly as the juvenile use of anabolics should be discouraged, there is a major question as to whether our nation's present "criminalization" approach is working. See, Do Our Anabolic Steroid Laws Work? section.]
Adverse Effects of Excess Androgens
The average adult male production of testosterone is less than 10 milligrams (mg) per day. Supplemental androgens can raise blood androgen levels to many times the amount that could be naturally produced. All these extra androgens will effect the body's hormonal balance, including the reproductive system. Because anabolics mimic endogenous androgens (i.e., your own natural testosterone) in the negative feedback loop of the hypothalamic-pituitary-gonadal axis, they cause the body to decrease its own production. Exactly how long it takes for the body to begin to shut down its own production of androgens is uncertain, although some have estimated it at about three weeks of steroid therapy. This induced hypogonadal state is characterized by decreased serum testosterone levels, associated testicular atrophy, and impaired sperm production that results in temporary infertility. It is this aspect of anabolic therapy that has been the focus of numerous studies testing the use of anabolics as a form of male contraception. But it is important to note that these effects are reversible with discontinuance of the steroids (Haupt and Rovere, 1984, p. 481), and that no case of permanent sterility as a result of prolonged high-dose steroid consumption has ever been reliably documented (Yesalis and Cowart, 1998, p. 53).
Steroid use can also effect the libido. It is common for the sex drive to heighten during a cycle but decrease toward the end and after because the body's own production of testosterone has been temporarily shut down due to the exogenous steroids. Decreased testicular size is also not uncommon with prolonged usage. Both of these adverse effects are reversible upon the body's own recuperation and often can be avoided altogether with the administration of gonadotropin stimulating drugs, which "jump-start" the body's natural production of testosterone (Phillips, 1991, p. 131; Di Pasquale, 1990, pp. 24-26).
Other adverse effects of excessive androgens upon the body's system of hormones are primarily due to the eventual conversion of the androgens into other compounds. Earlier, we noted that steroid molecules in the body are eventually converted into other compounds or excreted in the urine (see How do Anabolic Steroids Work in the Body? section). Testosterone can be converted by an enzymatic process into a slightly altered derivative hormone called dihydrotestosterone (DHT), a steroid molecule that may be significantly responsible for these adverse effects. Adverse effects of an androgenic nature occur because muscles are not the only parts of the body with receptor sites for steroid molecules, and because a steroid molecule has the potential to deliver several different messages. Which message the steroid molecule delivers depends upon the location of the receptor site to which it links. A steroid molecule linking to a receptor site in a hair follicle may deliver a message to stop growing (leading to male pattern baldness). One linking to a site in a sebaceous gland may deliver a message to produce more oil (leading to acne). One linking to a site in the prostate gland may deliver a message for the gland to enlarge (leading to prostatitis). The occurrence and extent of these adverse effects depend upon the concentration of receptor sites for steroid molecules in that particular area. Each individual is different. For example, male pattern baldness can be exacerbated in athletes who have a genetic predisposition. Steroids with a high conversion rate to DHT seem to be particularly responsible for this adverse effect, and should be avoided. Also, the effect can be partially controlled by the use of finasteride (Proscar or Propecia), a prescription drug which helps to block the conversion of testosterone to DHT.
The appearance of androgenic effects is also largely related to the dosage and to the choice of steroid. Highly androgenic steroids such as testosterone esters, especially in very large doses, will generally be much more prone to cause problems than highly anabolic, less androgenic drugs like methenolone or oxandrolone. However, recent research suggests that the side effects of even highly androgenic compounds have been overstated. There were no significant side effects of 10 weeks of testosterone enanthate at a dosage of 600 mg per week (six times the replacement dose of this highly androgenic ester and more than many bodybuilders might use) (Bhasin,et al.). (In a discouraging kick in the pants to natural athletes everywhere, study participants receiving the testosterone injections without any exercise at all enjoyed significantly greater increases in fat-free mass, arm size and leg size than those who worked out hard but without the steroids.) Other studies have also reported minimal significant androgenic side effects (Pope & Katz, 1994), including one involving the highly androgenic oral steroid oxymetholone (Hengge, et al.). Androgens also have the capacity to be converted into estrogen by chemical reactions and enzymes within certain body tissues. The process by which the steroid molecule is converted to estrogen is called aromatization. Those anabolics that are easily aromatized into estrogen can cause a feminization of the breast tissue known as gynecomastia. While largely dose related, a natural propensity for this condition can cause it to occur even in moderate dosages. This condition can often be avoided or arrested by the judicious use of anti-estrogenic compounds. Once a serious cosmetic problem exists, minor surgery is required to correct it. Numerous professional bodybuilders have had this surgery (Phillips, p. 125) and others obviously need it (look closely at a very top place finisher in the 1998 Mr. Olympia lineup).
Anabolic Steroids and the Liver
Anabolic steroids are processed by the liver. As discussed earlier, C-17 alkylated oral steroids (steroids with an alkyl group added at the alpha position of the "C-17" or number 17 carbon atom of the molecule to withstand total degradation on their first pass through the liver [see Steroids 101 section above]) are unusually harsh on the liver. For this reason, even moderate short-term administration of these C-17 oral steroids can effect liver function test readings. Elevated liver counts indicating liver stress (toxicity) have been reported in recent studies of somewhat moderate oral anabolic steroid therapy (daily doses of 40 and 80 mg of oxandrolone [Oxandrin, formerly Anavar]) as reported in the online periodical Medibolics, edited by Michael Mooney (www.medibolics.com). However, these elevated liver function readings will return to normal after cessation of a moderate, short-term steroid cycle. I could find not one case to the contrary. Further, it is recognized that intense weight training alone often causes changes in liver function tests, including SGOT, SGPT and LDH (this is something that all physicians monitoring athletes using anabolics should be familiar with).
The more serious liver problems attributed to anabolic steroid use include hepatocellular carcinoma (liver cancer) and peliosis hepatitis (blood-filled sacs within the liver). But the majority of cases reporting liver problems have dealt with extremely sick and elderly patients treated with C-17 alkylated oral steroids for years of continuous use, and many of these patients had a particular type of anemia linked to liver tumors even without anabolic steroid therapy. A computer search of the medical literature looking for steroid-associated liver tumors could find only three in athletes (Friedl, 1990). Of the three athletes, one was using 700 mg of oxymetholone a week for five straight years, and one had a tumor more indicative of classic liver cancer than of steroid-associated tumors. Virtually all of the reported liver problems seemed to occur with the 17 alpha-alkylated oral steroids. There have been no cysts or liver tumors reported in athletes using the 17 beta-esterified injectable steroids (Wright&Cowart, p. 61). It has been noted that injectable steroids generally appear to have little effect on the liver at all (Haupt, 1993, p. 469).
Recent studies continue to suggest that reports of serious adverse effects of anabolic steroids upon the liver in healthy athletes may be highly overstated. In a study of athletes, of the 53 current or past steroid users who underwent laboratory testing, only one subject displayed an abnormal liver test (Pope&Katz, 1994, p. 379; incidentally, on physical examination, not one user displayed evidence of any major abnormalities possibly attributable to steroids, such as high blood pressure, edema, acne or hair loss.) Another study tested one of the most powerful and reputedly dangerously toxic anabolic steroids for 30 weeks on HIV positive men and women (Hengge et al.). Oxymetholone, formerly known as Anadrol in the U.S. and a C-17 alkylated oral steroid, was administered in a dosage of over 1,000 mg per week (more than that used by many bodybuilders, and for a much longer duration of uninterrupted use). The results were significant gains in lean muscle mass -- even without any weightlifting. Even more importantly - and surprisingly -- there were no significant problems with liver function, water retention, or virilization side effects (it will be interesting to see whether further studies yield consistent findings at such high dosages).
While the dangers of anabolics to athletes' livers appear to have been highly exaggerated, it must be recognized that an apparently healthy athlete with a previously existing but undiscovered liver problem could do serious damage to himself by self-administering C-17 oral anabolic steroids. For this reason alone, it would be quite irresponsible for any athlete to use anabolic steroids without having a physician regularly conduct blood tests to monitor liver function.
Anabolic Steroids and the Heart
How cardiac risk might be increased by the use of steroids is a subject of speculation and some controversy. High blood pressure is perhaps "one of the most exaggerated claims" of steroid-related health risks, and remains unconfirmed despite numerous studies (Friedl, 1993, pp. 119-120). Regarding blood lipid levels, oral steroids in particular seem to cause a reduction in HDL (high-density lipoprotein cholesterol) levels in some steroid users. However, changes in the blood lipid levels now appear to begin to recover within about a month after discontinued use, and, in fact, most studies do not report an increase in total cholesterol (Yesalis&Cowart, p. 54).
In examining cardiovascular risks, often cited is a case report by (R.A. McNutt, et al, 1988), concerning a 22-year-old steroid-using weightlifter who experienced a sudden heart attack. While often held out by anti-steroid authorities as the "smoking gun" connecting steroid use to heart attacks, a reading of the actual report reveals that the subject weighed 330 pounds and had a total serum cholesterol of a whopping 596 mg/dl! The fact that so few similar case studies exist may well indicate that the condition of this individual was hardly representative of the majority of athletes who use steroids. (Nonetheless, all strength athletes, including steroid users, should regularly monitor serum cholesterol. Obviously, this poor fellow didn't get his cholesterol to 596 overnight, and it is not reported when he last visited a physician prior to his heart attack. To what extent our nation's criminalization approach to steroids, which discourages steroid-users from seeing doctors, contributed to this result is open to speculation.)
While the question of whether short-term, reversible alterations of these cardiac risk factors are detrimental to long-term cardiac health is "unanswered" at this time (Haupt, p. 469), it has been suggested that some characteristics of steroid-users - intense exercising, low body fat, and avoidance of smoking -- tend to put them in a low-risk group for heart disease (Friedl, 1993, p. 120).
Based on our present information, cardiac risks seem to be primarily related to high dosages in the absence of physician monitoring. Jose Antonio, PhD., a nationally recognized authority on drugs in sports who has written a monthly column for Flex magazine, cites a study examining serious cardiovascular side effects in four weightlifters using "massive amounts" of steroids (Antonio, 1998). While there is little doubt that the health problems of these men were caused by their anabolic steroid abuse, these were clearly mega-dose abusers. "[H]igh dose equals high risk," notes Dr. Antonio, but "low-dose androgens (e.g., 200-600 mg per week for 10 weeks) pose little threat to health."
Anabolic Steroids and the Prostate
A legitimate concern is the potential adverse effect of excessive androgens on the prostate gland. While there is one case report of prostate cancer in a bodybuilder (Roberts&Essenhigh, 1986), no studies have shown an increased risk or incidence of prostatic cancer or hypertrophy with androgen use or indicated that androgens per se predispose to these conditions (Swerdloff&Wang, 1993). Numerous male contraceptive studies using up to 200 mg/week for over a year show no evidence of prostate stimulation. Researchers at the University of Iowa recently examined the prostate effects of the administration for 15 weeks of up to 500 mg/week to healthy men in their twenties and thirties (Cooper, et al., 1998, pp. 441-43). No changes in prostate size or serum prostate specific antigen (PSA) levels were detected either during or up to 25 weeks after the last dose. Further, androgens are not the only or even the main causative factor in prostate cancer, as evinced by a case study in which a chronically testosterone deficient man developed prostate cancer (Boccon, 1991, et al.). Warning: this does not necessarily mean that much higher dosages, especially of highly androgenic compounds, might not adversely effect the prostate, especially in older men. It is not known if athletes who have used steroids for prolonged periods will encounter more prostatic problems as they age (Di Pasquale, 1990, p. 62).
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Originally Posted by gettinthere
