How to Measure Liquidex
Some of you have been asking so im posting this from Riker29 at EF. PLEASE NOTE THAT YOU CAN TAKE .5MG EOD AND ACHIEVE THE SAME RESULTS AS .25 ED, DUE TO LONG HALF LIFE.
How to Measure Liquidex
I just did a small experiment that may help some other guys.
Liquidex, the liquid sort of "generic" version of Arimidex, is a very concentrated substance, with 4 mg/ml being its rated concentration.
Arimidex is very potent (and not cheap either) and in many cases a person only needs to do like 1/4 mg of it for it to be effective.
But at that concentration,
1/4 mg of Arimidex.
in Liquidex at 4 mg/ml, means that ,
you would need to adminster 1/16 of a ml (cc)!
How the hell do you measure that?
Well, here is what I did.
The formulation of a "drop" of a liquid is actually a fairly controlled and repeatable process. Meaning, if all factors (liquid viscosity, temperature, etc.) are the same, the amount of liquid in each drop is fairly constant (if the drop is formed around a constant source .... lilke .... the heads of a hollow needle .....).
So, I took a syringe, and sucked up like 3 CCs+ into it.
Wiwth an 18 gauge needle on the syringe, I carefully, slowly, pushed down the plnger, ....... and counted each drop ....
And after several trials, with very low amount of "drift" or changes in data, it turns out that ...
Liquidex, through an 18 gauge needle, at room temp, with the needle held stright down, will create 50 drops per ml.
So, extraploating from that (with a slight amount of "rounding" error),
When using Liquidex, take an 18 gauge needle and with the liquid at room temp, and with the needle held straight down,
for 1 mg Arimidex, measure 12 drops.
for 1/2 mg of Arimidex, measure 6 drops.
for 1/4 mg of Arimidex, measure 3 drops.
Hope this helps some people out there.
And for those that were thinking "did this guy WASTE all of that Liquidex?" - not a chance. I "dropped" it into the back end of another syringe, and then placed it back into the vial.
There are a few variables people have mentioned.
Given a certain liquid, and a certain surrounding pressure (air pressure) and a certain physical configuration (like the end of the needle) then you have still several variables which come into play:
Temperature
This is important because variations in temperature will change viscosity, which will effect the droplet size. However, at normal room temp (68-74F) this should remain fairly stable with that range.
Pressure
This could be an issue. At one extreme, if you jammed the plunger down - this would obviously effect drop size! It would probably be a stream!
OK, maybe not, thats some fairly thick stuff.
The key is that you want to apply enough pressure so that the "drop" forms by having the liquid pool up on the tip, and to continue to do so .... to form into a drop ..... and because of surface tension of the liquid against the needle, the drop will get larger, but still hold on .... then at some point, the gravitational pull on the liquid is such that it overcomes the surface tension which tends to make the liquid "cling" to the end of the needle.
When gravity pulls down more than the surface tension can hold, a drop ..... drops.
So its imprtant to push the plunger slowly enough so that the drop formaulation is almost entirely consisting of this effect of gravity-vs-surface-tension, and NOT due to the mechanical effect of liquid "pushing" itself off the needle tip.
In any event, push slowly and consistently. I was dropping at about 1 per second. That seemed fine.
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:'( .................. sniff, sniff - cant we at least be friends???
ummmmm.........dont think so. maybe it takes longer/shorter to disperse the bolus but tests half life is not dose dependent. Please, oh please post that study. 
they will be able to explain it to you in more professional words.
