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05-17-2007, 08:51 PM #1Junior Member
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Chronic Fatigue Syndrome and HRT Questions about dosing.
Currently I am having great difficulty in getting my physicians to do what global and national research physicians recommend related to HRT for Chronic Fatigue SYndrome. I've been doing a tremendous amount of research and purchased some things which aren't here yet. I am worried about doing this by myself wsith no real instructional guide other than to spend weeks pouring over these types of bulletin board systems and other internet site. What I've found so far is that I should take the following
HCG 24 IU a month in 5 day a week subcutaneous shots
Testosterone Cypionate 100mg weekly injections intramuscular
Clomiphene Citrate 51mg pill a day
Anastrozole 1mg pill a day
HCG 10,000 IU a month in 5 day a week subcutaneous
shots.
My question is does anyone have any suggestions and is there any issue with necessary cycling with this regimine? how many days on and how many days off.
I need to increase cellular communcation, IGF-1 levels and ATP and mitochondrial function. That is the purpose of this treatment not to be muscle stud or prevent aging. I am 45 but my Testosterone , DHEAS, Thyoid, IGG and IGF levels are all low and my cortisol is high.
Hoping to get tangible advice since I can't seem to find a doctor to assist me without flying to the mainland.
VItamin supplementation has improved my circumstances about 40-50 percent so far from being bedridden. Now I'd like to be back where I was pre-illness.
THank you in advance.
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05-17-2007, 09:03 PM #2
which vitamins helped?
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05-17-2007, 09:16 PM #3
I was once diagnosed with having Chronic fatigue syndrome so I researched it. I haven't looked it up recently but back in 91' I read that 90% of the population would test positive for Epstein Barr virus which was thought to be the underlying cause of CFS. The problem is the majority of those people with EBV don't have the symptoms of CFS. So it's a diagnosis based on symptoms but you can't find something in a tray (like you can with HIV). Therefore, the majority of the physicians had little respect for this "Chronic Fatigue Syndrome." It was once called "yuppie hysterica." I had the symptoms but I believe that CFS is similar to God. You have to have faith that it's real. But I'll tell you, feeling abnormally tired and having impaired concentration was very real to me. Maybe I was just ***ressed.
Originally Posted by Jawncy
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05-17-2007, 10:09 PM #4
is there any cure for the Epstein bar virus?
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05-17-2007, 10:11 PM #5
jawncy
you have been doing some real impressive research
with hgh it is recomended from most people to do between 2-4 ius per day for 5 days-then 2 off
so 24 ius per month seems very low amount
with test cyp at 100mg per week is a good trt dose and no it is not cycled if you are low test needing hrt
hcg is something you do on and off but I do not have enough info to get you good advice on the other stuff
good luck bro
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05-17-2007, 10:41 PM #6Junior Member
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See this thread and links
http://forums.steroid.com/showthread...=1#post3484505
At the top is what I am taking and what has helped and down below is some information about doctors and other treatment protocols for this. It isn't in my head.
Mitochondrial function are off, IGG and IGF levels are off, testosterone is off, DHEAS is low, cortisol is high. Cyt*****lovirus is off the charts and thyroid doesn't work.
I am not imaging these problems. I was bedridden for 9 months and now I am up and around due specifically to supplementation that was suggested by the global specialsts.
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05-17-2007, 10:44 PM #7Junior Member
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CFS Test
Actually there is a test that can be done by Redlabs USA in Nevada that proves beyond a shadow of a doubt that you have it. There is a new medication called Ampligen that has shown tremendous promise the test that REDLABS has is part of that FDA study protocol.
The test is very hard to do since it requires very strict control over the blood and very specific shipping protocols.
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05-17-2007, 10:48 PM #8Junior Member
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Epstein Barr Cure
There is a cure for Epstein Barr. I had the virus but it is now gone with a cycle of gancyclovir antiviral medication.
This virus can be killed with the gancyclovir where cyto meg-alovirus cannot be killed and there is no cure for this problem which is what I have.
It is not HIV related but all of the same blood related problems result in low T cell counts and an inability for the blood to clot well and the previous levels being off.
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05-18-2007, 01:02 AM #9
do you know the symptoms of epstein barr? i tried loking it up and couldnt find any?
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05-18-2007, 01:29 AM #10
your going to have problems if you run those compounds year round mate.. About the only thing you have right is the test dose. The GH is too low and the other compounds should not be run on a year round basis due to there sides (some possibly quite unpleasant and even dangerous)
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05-18-2007, 02:32 AM #11Originally Posted by perfectbeast2001
not sure what he's attempting to achieve with the clomiphene citrate, other gear does the same job better with less sides.
arimidex year round? the lowered estrogen might screw his lipid profile, but it's milder than femara, and with a significant amount of exogenous test, the adex might just leave his estro in the normal range anyway. nolva tends to blunt this effect as well.
in addition to the HRT approach, i would also try provigil (great for some, not so great for others). if you feel like being edgy, also try selegeline (research it at imminst.org - cool stuff, also boosted life span by 20% in animal studies).
also, remedyfind.com has a list of every known treatment for CFS and real world ratings and feedback by real people who have tried them. means less BS from the pharmaceutical companies and other groups with dollars and agendas at stake.
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05-18-2007, 02:57 AM #12Originally Posted by MMA
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05-18-2007, 08:58 PM #13Junior Member
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Selegeline or L-***renyl
See this website http://www.selegiline.com/ after you read this.
You can get these very inexpensively at www.alldaychemist.com
Selegiline, popularly known as l-***renyl, has life-enhancing properties. Selegiline is a selective, irreversible MAO-b inhibitor with antioxidant, immune-system-boosting and anti-neurodegenerative effects. It retards the metabolism not just of dopamine but also of phenylethylamine, a trace amine also found in chocolate and released when we're in love. Selegiline also stimulates the release of superoxide dismutase (SOD); SOD is a key enzyme which helps to quench damaging free-radicals.
Taken consistently in low doses, selegiline extends the life-expectancy of rats by some 20%; enhances drive, libido and endurance; and in***endently improves cognitive performance in Alzheimer's patients and in some healthy normals. It is used successfully to treat canine cognitive dysfunction syndrome (CDS) in dogs. In 2006, higher dose (i.e. less MAO-b selective) selegiline was licensed as the anti***ressant EMSAM, a transdermal patch. Selegiline also protects the brain's dopamine cells from oxidative stress. The brain has only about 30-40 thousand dopaminergic neurons in all. It tends to lose perhaps 13% a decade in adult life. An eventual 70%-80% loss leads to the dopamine-deficiency disorder Parkinson's disease and frequently ***ression. Clearly anything that spares so precious a resource might prove a valuable tool for life-enrichment
The dose for adulst seems to be between 5-10mg a day. It is very inexpensive at about 12 CENTS a pill (5mg).
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05-18-2007, 08:59 PM #14Junior Member
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Word for Selegeline
L- De .Pr. en. yl
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05-19-2007, 02:26 AM #15
have u tried it?
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05-19-2007, 10:14 AM #16
used it, loved it. feel great, energy, mentally sharper. focused. one small drawback - a tiny, tiny bit of of it metabolizes into amphetamnine. to be be perfectly clear, THIS IS NOT IT'S MODE OF ACTION, JUST A SMALL METABOLITE! about a cup of coffee worth of stim. however, because of this, you will piss hot on all drug tests, so i can only use it part time.
they invented a substitute with no amphetamine metabolites, called rasigiline (sp?), but it's MUCH more expensive.
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05-19-2007, 10:23 AM #17
if dopamine is your problem, you might also consider a provigil/wellbutrin combo, they both affect dopamine and stack nicely. you'll feel better, more energetic, and if you're still in school, your grades may go up dramaticly.
FYI - the Nootropic movement has some very interesting stuff out now. nootropics are the "smart drugs" - basicly steroids for your brain. they've finally gotten to the point where they have synergistic combos that can dramaticly increase your mental performance. juicing your brain is much more complicated that juicing your body however, and what works for some may not work for others. you'll just have to get a list of the things that usually benefit your condition, and keep playing around with them until you find a combo that does what you need and has few sides.
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05-19-2007, 10:27 AM #18
at some elite high schools, 80% of the student body has been diagnosed with "ADD". this basicly means they lack the concentration to study dense German philosophy for 15 hours at a time. unless they're medicated. performance enhancemnt has gone way beyond high school football players juicing up.
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05-19-2007, 10:30 AM #19Originally Posted by Jawncy
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05-19-2007, 12:34 PM #20Originally Posted by MMA
really...i was gunna do 10. dopamine is 50 on a 150-300 scale same with serotonin and norep and all those are just as low like i said. ill do 2.5 mg 2ce a day. trying to talk drs into it but if they dont soon im gunna do it myself.
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05-20-2007, 02:22 AM #21Originally Posted by MMA
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05-21-2007, 08:42 PM #22Originally Posted by ironaddict69
the whole point of *** is that it doesn't have the horrificly lethal side effects other MAOI's do. MAOIs are so sensitive, they interact with drugs you aren't even taking i f your dosages get too high, you may start to get the usual MAOI sides. a cheeseburger could kill you.
i went as high as 5mg, but it was too intense. no need for it either. see if it it resolves your issues a lower doses first. NOTE - weird half life, wait a week or 2 before raising dosage.
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05-22-2007, 12:39 AM #23Originally Posted by MMA
ya i ordered it off a research chem site today cuz doc wudnt budge on it, he said well u had such a bad reaction to caber this is gunna be the same! so are u saying like u got way too horny and aggressive and hypr or what? tell me what to expect. BTW how long does it usually take for AG guys to deliver?
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05-22-2007, 01:39 AM #24Junior Member
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L *** Ren YL
why didn't you get the drug from alldaychemist.com. It's the cheapest.
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05-22-2007, 01:41 AM #25Junior Member
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It's only a dollar thirty five cents for 10 pills at alldaychemist.com look under selegiline on the left side second dropdown list.
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05-22-2007, 01:43 AM #26Junior Member
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It's only a dollar ten cents for ten over there.
It's only a dollar thirty five cents for 10 pills at alldaychemist.com look under selegiline on the left side second dropdown list.
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05-22-2007, 01:53 AM #27Junior Member
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Originally Posted by Jawncy
I'de get on the test, wait a while, get your estradiol checked alonside your Test. If the estradiol needs to be lowered start on 0.25mg e3d. Then adjust from there.
What is the point in the clomid on top of the arimidex, and testosterone?
What were your test results btw?
I wouldn't be going on all that stuff right away. Post up your blood tests.Last edited by lacey231; 05-22-2007 at 02:01 AM.
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05-22-2007, 03:06 AM #28Originally Posted by Jawncy
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05-22-2007, 12:32 PM #29Junior Member
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sorry
It's just so much cheaper. I've seen that de pre nyl at 69.00 for 30 pills. This is all I"m saying. .13 a pill or 2.00 a pill. Big difference to me anyway.
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05-22-2007, 12:51 PM #30Junior Member
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Lacey
Thanks for the tangible information. AFter I posted this I got Dr. Crisler's protocol for TRT and then went onto some medical sites and started to research the chemistry and biology of what occurs. I'm getting blood to day or tomorrow from Crisler's suggestions as well as a dozen others if my doc will order them to see what is really going on with me. I know my T4 and T3 are at high levels (near top) and my TSH is very low (near bottom) identifying that it isn't my thyroid unless a REVERSE T3 is occuring preventing increases is tissue thyroid levels. After continued research I will definitely do as you and Dr. Crisler recommends 100mg test once weekly for 5 weeks - do blood tests - look at estriole E2, free test, bioavailable test - then add HCG of 250 IU 2 days preceding the test shot - then after another month check estriole and if necessary add that .25 e3d. The clomid and the anastrozole have different mechanisms. For insance when the HCG is too high, it affects blood estrogen levels thus the needs for an Aromatase Inhibitor like anastrozole. THe clomid is a SERM - Selective Estrogen Receptor Modulator preventing atagonistic estrogen from being assimilated as it blocks it's uptatke at the receptor level.
Please post your suggestion for a TRT / Anti Aging regime. I have not found any detiled information about this anywhere in the for that Dr. Crisler has provided. Easily understood, planned, what to look for, etc.
Look forward to your posts and knowledge about this. I'll get my lab tests taken soon. I have very high liver enzymes due to tylenol poisoning 5 years ago. I have very high cholesterol. Low DHEAS, High Cortisol. I thnk that I suffered from an almost complete breakdown of the Adrenal, Hypothalmus, Thyroid, Pituitary Axis. There is an excellent site called Thyroid Disease Manager located at http://www.thyroidmanager.org/ which gives very excellent detailed scientific information which I am able to assimilate due to my medical billing experience. My company has done outsourced medical billing and medical office management as a part of our services lineup before I got sick. Terrific Site sponsored by the company that makes Synthroid . I learned a lot about the HPTA axis there that I found nowhere else. The acttual mechamism - here is the link to the document in pdf form for those who want information about the thyroid - http://www.thyroidmanager.org/chapter4/chapter4.pdf. If you replace the chapter 4 with a 1 in both places http://www.thyroidmanager.org/chapter1/chapter1.pdf and so forth you'll get the entire textbook. THe chapters available are 1, 2, 4, 7, 8, 9, 10, 11, 12, 14, 15, 17, 19, 20 and 21. Just change the number and download the entire textbook on thyroid issues. This is a college medical textbook on the subject so be aware that the entire discipline if covered in the most detailed biological and chemical terms down to the cellular levels. It is heady but if you are able to understand some of it, you'll come away with a more complete understanding of the mechamism and interrelationships of the THyroid with the Hypothalmus, Adrenal, Pituitary systems.
Hope I wasn't too boring and off point.
Look forward to additional suggestions about Anti Aging, Hormone Replacement and other related issues.
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05-22-2007, 04:00 PM #31Junior Member
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Originally Posted by Jawncy
What you should be doing is following exactly what Crisler said. Take the 100mg Test shot, get your blood work checked, add the Hcg, get your blood work checked for Estradiol (not estriole, didn't know if that was a sp mistake).
You don't need clomid on top of arimidex (anastrozol). The arimidex will lower your estrogen enough to normal levels, so you don't need to block anything at the receptor cites. Arimidex is VERY strong stuff. you don't need close to 1mg a day. like I said eariler .25mg e3d seems to be a decent dose for most people on 100mg test. More is not better here it's about hte T to E balance, if you lower Estrogen too much you end up with the same feeling as if you had low T.
The cortisol, and DHEA might sort it self out after you get that far. Cross that bridge when yuo get there. The extra LH from the Hcg could give you more DHEA due to the P455scc enzyme, and I've also heard many people whos Cortisol gets wacky with low Test. Testosterone plays a key role with Cholesterol so that might get better as well. Keep an eye on it. IF the DHEA isn't better crisler usually adds some in.
If all this dosn't work after your test and E levels are in check then you might think about adding HGH, but not until then. Change one thing at a time, get the blood work and go from there. It takes time but if you started throwing everything you have on that list in at once, you'de probably still feel like crap, and not know exactly where to start.Last edited by lacey231; 05-22-2007 at 04:17 PM.
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05-22-2007, 06:25 PM #32Junior Member
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VERY balanced approach. I am not technically being seen by Crisler. I read his document. It seemed the mose level approach. I just saw an endocrinologist today who ordered many tests for related autoimmune dysfunction. Adrenal Antibody Screen, Islet Cell Antibody, Gastric Parietal Cell Antibody, Insulin C-Peptide, Testosterone Free and Total. My last two blood tests for T came out low. Since I have Hashimoto's Thyroiditis (an autoimmune disease) the disease is killing off other organis (causing hypogonadism and Lot T4) I also have a T4 to T3 conversion issue in that my body does not properly convert T4 to T3 so I started on Armour Thyroid today, hopefully I'll feel better. If my test results come back low a third time then I"ll get a testosterone replacement . THANKFULLY. SOmeone who'll listen. I've been dealing with this since November 2004 to no success.
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05-23-2007, 01:07 AM #33
jawcy have u tried the selegiline?
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05-23-2007, 03:31 AM #34Junior Member
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No I am going to order it soon. Doctor said I definitely have shown a low testosterone reading the last three tests since 2004 and my prior endocrinologist ignored it even after being told by me that it was low and it should be looked at. THis Endocrinologist said if the newest test comes back low that I'll have an scrip for testosterone right away.
I'm going through quite a bit now with my health care. I saw a specialist today who said I may have a very rare disease (only 14-20 per million) called Polyglandular Autoimmune Syndrome typically called "Schmidt's Syndrome". This is where the entire Endocrine system is being attacked by my bodies immune system called AutoImmune Disorder. Since I"ve been trying to find out what is really wrong with me the last 3 years I have been reluctant to try any new thing until I have this endocrine problems under control. It is a delicate balance.
I am looking forward to going on it though sounds exciting.
I GOT ARMOUR THYROID TODAY WITH THE T3. The doctor emphatically said I have a T4 to T3 conversion detriment and my body is not converting T4 to T3 properly. The body has a T4 to T3 ratio of 3/5 (3 of T3 and 5 of T4). The Armour thyroid is a 5/3 reverse ratio since it comes from dessicated cows thyroid. If thsi is too much T3 then he will put me on cytomel and levothyroxine after a time to see if this works.
Long answer but in short no.
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05-23-2007, 03:23 PM #35Junior Member
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I read from several subjective sources (personal experiences) that on occasion the pill form of De pre nyl (selegeline) can have a different metabolic effect than desired. Under these circumstances a LIQUID form of the product can be taken and there is one at http://www.selepryl.com/. It is a very large supply of the medication - at least 2-4 months with normal use for around 70.00. Look up the work selepryl and you'll see it on google.
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05-23-2007, 03:26 PM #36Junior Member
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If you are taking this medication or considering it please read that website because there are noted drug precautions and interactions which will not work with this medication.
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05-23-2007, 09:09 PM #37Originally Posted by Jawncy
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05-23-2007, 09:18 PM #38Junior Member
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I"ve heard the liquid product is superior but remember it is 300mg in the 12ml bottle so just a few drops will do it. Someone said it made them anxious and jittery and easy to jump with their anger. WHen they went on the liquid they did not have that problem. Also remember to look at the drug intereactions and if you are on one of those ant ***ressants or MAO inhibitors look at the dosing and talk to yoiur doctor. They couldn't explain it but they preferred the liquid. I"m getting my doctor to prescribe it to me and I'll start at 2.5 mg a day and take it from their. If ou take too much right away they say you'll have a problem with the body like headaches and upset stomach. The liquid is better assimilated but still be careful with it. Apparently it is strong.
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05-23-2007, 10:05 PM #39
im starting at 5 mg total, my dopamine is LOW. duuuude tell me, HOWD u get ur doc to do it? i think i can talk a different one into it.
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05-24-2007, 02:30 PM #40Junior Member
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Dude yourself, your profile isn't funny! knife? scary thought?!
Anyway, I just asked him to do it. I told him it was such and such an amount on the internet and could he please prescribe it for better cognitive functioning and memory. He did not have a problem with it at the 2.5 to 5 mg levels. I told him I need all the help I can get with my endcrine system all screwed up with this "schmidt's syndrom" (polyglandular autoimmune disorder). Maybe he felt sorry for me since he knows how sick I am and that I might need an extra edge? I am just glad. It's only a $10.00 copayment per month for anything.
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