hCG and Pregnenolone; What you should know.

[Chauffeur]

Kelkel, the study posted at the beginning of this thread shows that men on TRT responded well to 500iu of hCG EOD. Why is it that many posters feel that this number is too high?

Many seem to be seeing good results on 250iu EOD or even twice weekly.

According to that study, there was no significant increase in E2, but many forum posts I've read seem to caution against a dose that high due to E2 issues.

What has your experience been?

Thanks!

[MisterD]

Hey guys

Ive been on TRT for over a 1.5 years and my protocol never had hcg in it...

Im probably going to look in to having a baby next year so what do you guys think, am i screwed? Or do you think i can reproduce again?

I was thinking should i stop the TRT for 2 weeks and start my HCG like if i was on a cycle to let my body jump start or just keep on with my TRT and add the HCG?

Thanks

[kelkel]

No, not screwed. Just get hcg in your protocol asap.
Stay on TRT and simply add hcg in.

[2Sox]

I second what Kel says. Each individual is different but there have been reports of many men on this forum who have been off hCG longer than you and have had the success your looking for.

[2Sox]

Deleted

[2Sox]

Kelkel, the study posted at the beginning of this thread shows that men on TRT responded well to 500iu of hCG EOD. Why is it that many posters feel that this number is too high?

Many seem to be seeing good results on 250iu EOD or even twice weekly.

According to that study, there was no significant increase in E2, but many forum posts I've read seem to caution against a dose that high due to E2 issues.

What has your experience been?

Thanks!

I think because it's higher than most take. When I see the word "significant" I'm suspicious as to what exactly that means. The same raise of E2 in one individual can be very significant, while in another it won't be at all. 500iu EOD averages out to 1750iu/week - over a two week period. That's a substantial amount - which in my opinion will definitely impact E2 levels.

I take 125iu/day - does the job just fine - and I take 12.5mg Aromasin every six days to keep E2 stable on that amount.

[corageon]

This is something I've always tried to stress, it's not simply just about testosterone when you get shut down - or when people go on TRT - because even with TRT - you aren't replacing other vital hormones LIKE Pregnenolone & DHEA, not to mention other hormones that are formed through the same pathways coming FROM And TO gonadotropic nerve pathways - such as oxytocin, vasopressin etc......I think when things aren't working normally; or naturally, there is a whole lot of things that people are missing out on....The optimal situation is of course, keeping your natural test production going, and in an optimal ratio with all other hormones.....unless ofc you have a testicular injury that is expected to last ; then TRT may be prudent if you ever want some degree of quality of life and vitality......

To be clear, I'm not against folks who are on TRT - and there may very well be other reasons - but at least supplement with the other neurosteroids AS WELL....and at some point you may find some other solution besides TRT...again, TOTALLY UP TO THE PERSON IN QUESTION.

Other interesting compounds similar to or re-booting natural test production would be....
-Opiate antagonists; naltrexone
-D-Aspartic Acid/NMDA
-WAY 100,635 (very very hard to obtain, unless you have/know a lab or can get from sigma)
-Isolated amentoflavone
-Forskolin

[HGH4Lymes]

thanks for the great read. i've read the same recommendation several times on the site too.
my doc automatically started me on HCG and anastrolozle w/ my test treatment. this is good piece of mind knowing i have a knowledgeable doc. they say never have blind faith in an accountant, doctor or lawyer or you'll end up broke, sick and in jail

[MisterD]

Guys,

Im changing my protocol to Sub Q
50mgs on Monday and 50mgs on Thurs of Test.
I know that 100ius of HCP ED is best but if i wanted to do EOD or 3 times a week would I be doing 250ius of HCG on Sunday, Wed and Friday or just do EOD and what ever day its lands?

[kelkel]

Your preference is all that matter. There's nothing saying daily is better, just some prefer it. I go M-W-F @250 but am considering just adding it to my test shot twice per week and upping the amount to about 350 IU's. Do what fits your life. Don't over complicate it.

[MisterD]

Kekel

Are you going to do it in the same pin?

Also my Doc is telling me to take GAC in a shot, do you know how effective it is?

Im also trying the semoreline before HGH.

[kelkel]

Haven't decided yet but I may.
GAC is just specific amino acids in injectable form. Injections will almost always absorb better. I've read good things about it.
I've run Sermorelin before and may again.

[thetanudj]

AM I ON THE RIGHT TRACK GUYS?

Total of 8ml of Bac Water mix w/ 10.000IU hcg powder
500iu/week will last 20 weeks

Each injection 250IU(Monday+Thurs)
Using "1/2 CC Insulin Syringe with 29 G X 1/2" pull out .2cc (25 units line)

Inject onto stomach fat.

Get 10ml Amber Sealed Vial to store mixed HCG, preload+put in freezer.

When need take syringe out 10-15 minutes before use.

[kelkel]

No. I gave you the link with mixing instructions yesterday in another thread. Mix it as the thread says.

[diehard09]

Thanks everyone. This thread has been very informative. I'm on hrt and fixing to add hcg and pregnenolone. This gives me a lot of much needed info.

[FONZY007]

AM I ON THE RIGHT TRACK GUYS?

Total of 8ml of Bac Water mix w/ 10.000IU hcg powder
500iu/week will last 20 weeks

Each injection 250IU(Monday+Thurs)
Using "1/2 CC Insulin Syringe with 29 G X 1/2" pull out .2cc (25 units line)

Inject onto stomach fat.

Get 10ml Amber Sealed Vial to store mixed HCG, preload+put in freezer.

When need take syringe out 10-15 minutes before use.

I didn't know you can store mixed hcg in freezer, won't damage hormone?

[IronClydes]

I can't tell if this thread is meaning to instruct the HRT patient on HcG to take Pregnenolone and DHEA or stating that HcG already takes care of that; rather those not on HcG need those. Anyone know?

225, 6', 33, 15% bf, bench 320, squat 405, dead 465.

[NotNATTY]

awesome

[IronClydes]

A typical dose is 50 to 200 mg daily best taken in the morning on an empty stomach (cream applied in the morning as well). Pregnenolone is considered safe and because is converts to DHEA which leads to other hormones it's best to get your Pregnenolone levels tested before supplementing.

DHEA Dose
 MEN
 Capsule – SR micronized
 50 mg Q am
 >200 lbs – 75 - 100 mg Q am

So, as a 232 pound 34 year old man on TRT, currently on the tail end of a blast, I should be taking 75-100mg DHEA and 50-200mg Pregnenolone? That's a large range...

[quinnbaylor]

Great read!! Thank you!!!

[Gorgos]

Does it applies to someone who decides to cycle for years without time off? I mean, can HCG be ran "safely" for years with appropriate dose? From what Im reading it looks like HCG is very important.

[Jamesmuscle]

great post,very helpful.

[max738]

A lot of really good information I agree a lot of GP'S and endo"s while they should have learned about this in med school a lot of them have forgotten it or they never learned it in the first place as somebody that has worked with
and along side many physicians some are a lot better than others.Medicine is so vast and complex anymore with all
we are discovering each year no physician can know all there is.A really good one told me years ago that there's
nothing hard about medicine it's knowing where to find the info when you need it.so doing your own home work
is to your advantage.Again a really good read<Thanks

[jimmy liu]

it is very helpful for me to have a better understanding the benifits and the difference of pregenenolone and hcg

[prenes]

If you add HGC to your cycle does it cut the effectiveness of external Testosterone ? would it cut my effective dose?

[kelkel]

Not at all. It will help preserve testicular function (ITT) as well as spermatogenesis.

[prenes]

thank you for the info.

[High Desert Bill]

Man, this is a really informative thread. I want to get on HCG as well. My doctor actually recommended it, for the shrinkage issue, but he cannot prescribe it in California. I believe I can get the DHEA at Walmart though, if I'm not mistaken.

[kelkel]

Man, this is a really informative thread. I want to get on HCG as well. My doctor actually recommended it, for the shrinkage issue, but he cannot prescribe it in California. I believe I can get the DHEA at Walmart though, if I'm not mistaken.

Just be sure the dhea is micronized for best absorption.

[High Desert Bill]

Just be sure the dhea is micronized for best absorption.

Will do, thanks.

[Rockyp]

Been on trt for 3 years. Only have used hcg 4 times. All endos say the research does not support the need for it in man my age, at the time 49. I am really scared of this stuff as now there is no turning back and while I felt better the 1st year I am not feeling great now. Lots of tendinitis, slow recovery from workouts , no sleep etc. Plus I am concerned as I get older one day I won’t have Ins to pass the test cyp. I feel like I screwed myself big time. I was screwed either way I guess as my T leveles were in the tank. Somehow I don’t feel I have a lot of time left. So far no real shrinkage but definitely a reduction in sperm. Libido is high but with marital issues there is no sex life. 2 small kids to whom I tend most of the time.
Sorry for the rambling but I am genuinely worried. My blood is ok as of dec last year. My test was around 500.

[BawdyEnglish]

Thanks for the informative read. Been on TRT for over 4 years, and will definitely incorporate this.

[Todayistomorrow]

I'm curious why 7-Keto DHEA is not recommended. I get that it doesn't boost T levels, but if one is already on TRT, then the positive effects of 7-Keto DHEA of not increasing E2 levels seems like a major positive. I heard Dr. Mark Gordon mention he uses 7-keto DHEA in his traumatic brain injury protocol so maybe it serves a different purpose than the BB community.

[Cornish]

Excellent Info! Thanks!

[zeph1ro7]

Great info. I'm natural atm, can I supplement with dhea and/or pregnenolone? thanks

[Philly Grappler]

Great info, thanks.

Unfortunately my brain hurts from math so I am hoping somebody could give me a straight answer to my two questions listed below.

1. The original post advises to mix 2ML of solution water to reconstitute 5000IU of HCG . I read on other sites to mix 5ml of water to reconstitute 5000IU of HCG. Just wondering why there are different answers to how much water to add to HCG.


2. I know this topic has been brought up but I am having difficulties grasping it. I have 100-unit insulin syringes. How much is 250 on a 100-unit insulin syringe? The original post stated each unit is 25IU but it was not mentioned what size insulin was being discussed (40 or 100-unit).


Thanks

[sledff2]

I reconstituted the 10,000 IU with 4ml. My insulin syringes only have 5 hash marks for every 10units/.1ml. Wanting to do 300iu/e3d. Is every hashmark 50iu on my insulin syringes then?

When using an insulin syringe, each unit (line) on the scale of the syringe equals 25IU's of hCG . 250IU’s of hCG is then 10 units on the side of the insulin syringe.

Thanks in advance!

[Cylon357]

I reconstituted the 10,000 IU with 4ml. My insulin syringes only have 5 hash marks for every 10units/.1ml. Wanting to do 300iu/e3d. Is every hashmark 50iu on my insulin syringes then?

When using an insulin syringe, each unit (line) on the scale of the syringe equals 25IU's of hCG . 250IU’s of hCG is then 10 units on the side of the insulin syringe.

Thanks in advance!

Your math is correct: each .01 of solution gives you 25iu of HCG. So .10 = 250iu and:

12 x 25 = 300

So draw .12 to get 300 iu.

[SweetChicken]

Been on trt for 3 years. Only have used hcg 4 times. All endos say the research does not support the need for it in man my age, at the time 49. I am really scared of this stuff as now there is no turning back and while I felt better the 1st year I am not feeling great now. Lots of tendinitis, slow recovery from workouts , no sleep etc. Plus I am concerned as I get older one day I won’t have Ins to pass the test cyp. I feel like I screwed myself big time. I was screwed either way I guess as my T leveles were in the tank. Somehow I don’t feel I have a lot of time left. So far no real shrinkage but definitely a reduction in sperm.

First, how do you not have shrinkage? What’s your test dosage? I am just over two months on it and my balls are becoming nonexistent. All day I feel like I’ve been kicked in the nuts. I’m getting off the trt and going to pct until my body is in homeostasis. I’ll decide later if I want to do a real cycle. And since I’m a little older than you, maybe in a few years my total T will drop low enough for my insurance to cover it. If I’m going to pay out of pocket like I currently am, I might as well run a full cycle.

[SweetChicken]

To answer your first question. The amount of water you mix with your peptide will determine the potency of the liquid in the syringe. For instance, 5000iu mixed with 5ml water will give you 1000iu in a 1ml syringe.

Use this to help full tool.
https://www.peptides.org/peptide-dosage-calculator/