I am in week 5 of my treatment and the doctor just yesterday started me on the HCG (his request). The shots were already preloaded in the needle and sitting in a basket on the counter?? I thought that once the HCG has been mixed it is required to be kept in the refrigerator? Does it make a huge difference either way? I know all of you guys on here are against the "clinics", but for right now it is the best option for me as they constantly monitor my levels with bloodwork and provide the arimidex, hcg, and test-C injections. I am sure that in the future I will find a doc who will just prescribe these to me and I can take them myself but being a newbie I am more concerned with safety then the pricing involved. I did not mention anything to the doctor as it took me a while to finally find a place that had everything I needed and I didn't want to ruin my relationship with the doctor so early in the process. Is it even worth mentioning to him that the HCG should be refrigerated or is the difference so minor it doesn't make a difference? Keep in mind I don't know if they make the shots in the morning and only use it for that day or if they make a bunch on Monday and it sits on the counter all week??