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  1. #1
    jimmyinkedup's Avatar
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    More anti aging but ....

    n international team of scientists have identified for the first time a key factor responsible for declining muscle repair during ageing, and discovered how to halt the process in mice with a common drug. Although an early study, the findings provide clues as to how muscles lose mass with age, which can result in weakness that affects mobility and may cause falls.

    The study, to be published in the journal Nature, involved researchers from King's College London, Harvard University and Massachusetts General Hospital.

    The study looked at stem cells found inside muscle – which are responsible for repairing injury – to find out why the ability of muscles to regenerate declines with age. A dormant reservoir of stem cells is present inside every muscle, ready to be activated by exercise and injury to repair any damage. When needed, these cells divide into hundreds of new muscle fibres that repair the muscle. At the end of the repairing process some of these cells also replenish the pool of dormant stem cells so that the muscle retains the ability to repair itself again and again.

    The researchers carried out a study on old mice and found the number of dormant stem cells present in the pool reduces with age, which could explain the decline in the muscle's ability to repair and regenerate as it gets older. When these old muscles were screened the team found high levels of FGF2, a protein that has the ability to stimulate cells to divide. While encouraging stem cells to divide and repair muscle is a normal and crucial process, they found that FGF2 could also awaken the dormant pool of stem cells even when they were not needed. The continued activation of dormant stem cells meant the pool was depleted over time, so when the muscle really needed stem cells to repair itself the muscle was unable to respond properly.

    Following this finding, the researchers attempted to inhibit FGF2 in old muscles to prevent the stem cell pool from being kick-started into action unnecessarily. By administering a common FGF2 inhibitor drug they were able to inhibit the decline in the number of muscle stem cells in the mice.

    Dr Albert Basson, Senior Lecturer at the King's College London Dental Institute, said: 'Preventing or reversing muscle wasting in old age in humans is still a way off, but this study has for the first time revealed a process which could be responsible for age-related muscle wasting, which is extremely exciting.

    'The finding opens up the possibility that one day we could develop treatments to make old muscles young again. If we could do this, we may be able to enable people to live more mobile, independent lives as they age.'

    Dr Andrew Brack, senior and corresponding author of the study from Harvard University, said: 'Analogous to the importance of recovery for athletes training for a sporting event, we now know that it is essential for adult stem cells to rest between bouts of expenditure. Preventing stem cell recuperation leads to their eventual demise.'

    Kieran Jones, co-author of the study from King's, added: 'We do not yet know how or why levels of the protein FGF2 increase with age, triggering stem cells to be activated when they are not needed. This is something that needs to be explored.

    'The next step is to analyse old muscle in humans to see if the same mechanism could be responsible for stem cell depletion in human muscle fibers, leading to loss of mass and wastage.'

  2. #2
    bass's Avatar
    bass is offline HRT Specialist ~ Knowledgeable Member
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    i love modern science! we probably be dead by the time FDA gives it an OK.

  3. #3
    Times Roman's Avatar
    Times Roman is offline Anabolic Member
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    Mr. Jimmy
    Where did you get this? What is the date of the article?
    I did a quick google and the "product" is already available on the market. Can't say if bogus or not, or even effective.....

  4. #4
    jimmyinkedup's Avatar
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    Quote Originally Posted by Times Roman View Post
    Mr. Jimmy
    Where did you get this? What is the date of the article?
    I did a quick google and the "product" is already available on the market. Can't say if bogus or not, or even effective.....
    The product was in existence before they did this. It was used for other purposes when they discovered this info.
    I found this on another board.

  5. #5
    Times Roman's Avatar
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    here is a direct link to the article, posted on the net yesterday....

    http://scienceblog.com/56839/scienti...-combat-aging/

    someone let me know if they know a legit legal source?
    Last edited by Times Roman; 09-28-2012 at 11:20 AM.

  6. #6
    kelkel's Avatar
    kelkel is offline HRT Specialist ~ AR-Platinum Elite-Hall of Famer ~ No Source Checks
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    Bass said he'd volunteer the "old muscle."

  7. #7
    bass's Avatar
    bass is offline HRT Specialist ~ Knowledgeable Member
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    hell at this stage anything goes, count me in!

  8. #8
    Times Roman's Avatar
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    Quote Originally Posted by bass View Post
    hell at this stage anything goes, count me in!
    well, scrounge up a source and let's check it out

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    Dano44 is offline New Member
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    Sounds cutting edge! I am definitely interested.

  10. #10
    MickeyKnox is offline Banned
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    Quote Originally Posted by Times Roman View Post
    well, scrounge up a source and let's check it out
    there's no source phishing. please edit your post sir. .lol

  11. #11
    MickeyKnox is offline Banned
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    Quote Originally Posted by bass View Post
    i love modern science! we probably be dead by the time FDA gives it an OK.
    you said it bro!

  12. #12
    Times Roman's Avatar
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    Quote Originally Posted by MickeyKnox View Post
    you said it bro!
    you cannot rely on the FDA for your health and well being. they are more sensitive to their own liability, not your quality of health. unless big pharm is pushing it and willing to spend the millions on clinical trials to get it approved, it won't happen, at least for the intended purpose we are discussing. until then, we are on our own, relying on the chinese or approved drugs for off label use.

    Sucks

  13. #13
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    Quote Originally Posted by bass View Post
    hell at this stage anything goes, count me in!
    That's funny

  14. #14
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    zaggahamma is offline Mr. Moderation
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    i wonder if trt activates these cells as most of us look younger than we would???? or i guess with this stem cell intervening we can x2 what we already have?

  15. #15
    Times Roman's Avatar
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    Quote Originally Posted by jpkman View Post
    i wonder if trt activates these cells as most of us look younger than we would???? or i guess with this stem cell intervening we can x2 what we already have?
    Mate,
    we weightlifters and our issues/concerns lie in the fringes of modern medicine and lack the deep pockets of big pharma and therefore must rely on dicey information and anecdotal evidence in most cases.
    You can always give it a shot and keep a journal here letting us know?

  16. #16
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    interesting read...sounds to me like it is a long way off from actually being understood enough to do humans any good.
    I didnt understand how they were able to activate or inhibit FGF2 at the proper times which seems to be the key to the whole theory.

  17. #17
    zaggahamma's Avatar
    zaggahamma is offline Mr. Moderation
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    Quote Originally Posted by Times Roman View Post
    Mate,
    we weightlifters and our issues/concerns lie in the fringes of modern medicine and lack the deep pockets of big pharma and therefore must rely on dicey information and anecdotal evidence in most cases.
    You can always give it a shot and keep a journal here letting us know?
    I'm good..u seen more the journal type

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