Adex questions

I know being on stane and adex year round is bad. and i think my liver is becoming toxic from adex, (not sure so please don't hang me up for saying that.) controlling e2 is good.

since the half life of adex is what 46 hours? in terms of the chemistry of blood plasma, hormone levels and everything in between. what happens if you only take a quarter pill only 2-3 times a week? will it help lower e2 then e2 will rise again then u lower it again? am i correct in thinking this way? I know with most drugs yo-yo effects are not good. any info or links would be helpful x 1000.

regards!

-mockery

I don't get what you're trying to do or aiming for here. But splitting the dose like that I don't think should harm anything. It's almost the same as Cabergoline, whose half-life is about 3 days. Be careful when doing this with Arimidex due to the estrogen rebound problem.

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Originally Posted by Atomini

I don't get what you're trying to do or aiming for here. But splitting the dose like that I don't think should harm anything. It's almost the same as Cabergoline, whose half-life is about 3 days. Be careful when doing this with Arimidex due to the estrogen rebound problem.

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Good sir, what do you mean? Dosing 2-3 times/week shouldn't have any estrogen rebound effects, especially not if you assume that it has a 72 hour half life(which it doesn't). I would be more concern with a resistance building up to the AI, considering he is on it year round.

Mockery, making sure that estrogen is not above range is good. But I would rather not use the AI unless you have to. The more literature I read about these non-steroidal aromatase inhibitors, the worse I think they are for our health. They suppress e2, but what else? What other metabolites are getting suppressed which we do not measure for? If the mechanism of action was so simple that it just lowers e2 then it would be fine, but these drugs and our bodies are so complex. Try to keep the drugs to a minimum, imo!

Mock what exactly is your TRT protocol? We're seeing more and more guys here able to get off the AI just by improving diet, reducing BF% as well as twice a week injection protocols, SQ, etc.

kel

ps: Atomini you get lost? Seeing how the other side lives over here? Ha!

If you only take a little bit, you only block a little aromatase (relatively), but the pharmacokinetics do not change.

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Originally Posted by kelkel

Mock what exactly is your TRT protocol? We're seeing more and more guys here able to get off the AI just by improving diet, reducing BF% as well as twice a week injection protocols, SQ, etc.

kel

ps: Atomini you get lost? Seeing how the other side lives over here? Ha!

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i asked his 2 cents on this thread, i left him a bread crumb trail

Trt is 180mg test depo cypinate 2 times a week, i suppose to be doing hcg 3 times a week but am only doing 2x, 3 x a week makes my balls sore and almost my prostate when i sit down. but my balls are back to full size now. i didnt use hcg for the first year of trt. i was running 12.5 stane for my ai , but in the past 3 months i have switched to adex and am running a cycle right now. 0.5 ed, only low estrogen sides is dry skin behind my ears. but will be trying .25 ed

Im bad asking questions cause my grammar is poor, i want to know in a nut shell if estrogen rebound is bad? so if i ran adex only 2x a week just to help lower it , or maybe as maintenance.

my diet is clean., and i do mean CLEAN. i was at 9% bf but im allowing a very small bulk to happen i will maybe get to 12% only 6 lbs over 8 weeks. I think my effort to supplement vit d has helped as well. my fat intake is around 50-60g daily and i think i will be increasing this to get more animal fats, yokes in as my body responds to these natural fats and works well with them.

i would like to ditch AI's all together. i know guys blasting for last 3 years and no ai ever run... they are fine, but they are not me.

if i broke up my 2x weekly shot into 4 dosages i think i could do the sub q, i know over .5 for me if i miss the muscle i get a lump and my gear crashes. . plus how the hell do you draw gear through a 29g needle or was the Dr. using a 25g? even a 25g ive never had luck drawing with.

What we need to see is your E2 sensitive assay, and how it has trended against other assays in the past.

180mg x 2/wk really isn't a solid TRT dose, especially factoring HCG into the equation, and keeping your serum levels on the high side for too long is only going cause negative sides all the way around, including too much conversion of E2 downstream, which then calls for more AI into the mix.

Guess with that said, I would really like to see all the available labs to see how your body is working with your protocol. If you can get the body into homeostasis, you can possibly get away from the AI's as you mentioned.

Bread crumbs, funny!

I vary shot locations and pins. Did SQ this am with a 31 ga slin pin. Just pull the plunger back beyond what you need and hold it and wait a minute or so. It will slowly fill up. Emphasis on slowly. I'm considering getting some 27ga 1/2" 3ml pins as with these I can go SQ and IM with the same pin everywhere but(t) glutes.

kel

Kelkel,

I use 27g 1/2" and definitely like them. I recently switched to a trial of subq and it works ok.

But before that I could do IM delts and quads and it worked well. And you're at a lower bodyfat than me by far so you would have absolutely no issues with getting a 1/2" into the muscle in those spots.

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Originally Posted by Vettester

What we need to see is your E2 sensitive assay, and how it has trended against other assays in the past.

180mg x 2/wk really isn't a solid TRT dose, especially factoring HCG into the equation, and keeping your serum levels on the high side for too long is only going cause negative sides all the way around, including too much conversion of E2 downstream, which then calls for more AI into the mix.

Guess with that said, I would really like to see all the available labs to see how your body is working with your protocol. If you can get the body into homeostasis, you can possibly get away from the AI's as you mentioned.

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sorry it isnt 180 x 2 its 180mg weekly and i split it into 2 shots.