Yet another good reason to take Cialis (Tadalafil) each day...

[steroid.com 1]

Testosterone:Estradiol Ratio Changes Associated with Long-Term Tadalafil Administration: A Pilot Study

Keywords:
Phosphodiesterase Inhibitor;Steroid Hormones;Estradiol;Testosterone;Chronic Treatment;Aromatase

ABSTRACT
Introduction.  It has been reported that lack of sexual activity due to erectile dysfunction (ED) may be associated with testosterone (T) decline.

Aim.  To investigate whether the known changes in sex hormones associated with resumption of sexual activity are sustained in the long term.

Main Outcome Measures.  Primary endpoints were variations from baseline of steroid hormones: total T, free T (f T), and estradiol (E). Secondary endpoints were variations of erectile function domain scores at International Index of Erectile Function-5 (IIEF-5).

Methods.  In an open-label fashion, 20 patients (mean age 54.8 ± 8.4 years) received tadalafil 10–20 mg on demand for 12 months. Exclusion criteria were those reported for phosphodiesterase inhibitors, including hypogonadism and hyperprolactinemia.

Results.  Tadalafil assumption was safe and well tolerated (overall adverse effects in 15% of patients) and none discontinued medication. A significant decrease in E levels occurred at the end of the study (from 19.9 ± 9.6 to 16.6 ± 8.1 ng/dL, P = 0.042 vs. baseline), with parallel increase in the T:E ratio (26.3 ± 15.3 to 32.6 ± 17.7, P = 0.05), whereas no changes in T and f T serum levels were observed, respectively (411.4 ± 131.4 to 434.2 ± 177.1 ng/dL and 47.7 ± 15.3 to 49.9 ± 19.1 pmol/L, not significant). Interestingly, nonparametric subgroup analysis for related samples revealed that E decrease was detectable only in lean (N = 14) but not in obese (N = 6, body mass index > 27.5 kg/m2) subjects (17.8 ± 10.1 vs. 13.5 ± 6.8, P < 0.05). A net increase in IIEF-5 scores was observed at the endpoint (13.7 ± 5.9 vs. 25.7 ± 2.9, P < 0.0001).

Conclusions.  Sustained improvement in sexual function after 12 months of tadalafil administration is associated with increased T:E ratio mainly related to reduction of E levels. We hypothesize that androgen–estrogen cross-talk and possible inhibition of aromatase activity during chronic exposure to tadalafil might have a role in the regulation of erectile function. Greco EA, Pili M, Bruzziches R, Corona G, Spera G, and Aversa A. Testosterone:estradiol ratio changes associated with long-term tadalafil administration: A pilot study. J Sex Med 2006;3:716–722.

[MuscleInk]

Testosterone:Estradiol Ratio Changes Associated with Long-Term Tadalafil Administration: A Pilot Study

Keywords:
Phosphodiesterase Inhibitor;Steroid Hormones;Estradiol;Testosterone;Chronic Treatment;Aromatase

ABSTRACT
Introduction. It has been reported that lack of sexual activity due to erectile dysfunction (ED) may be associated with testosterone (T) decline.

Aim. To investigate whether the known changes in sex hormones associated with resumption of sexual activity are sustained in the long term.

Main Outcome Measures. Primary endpoints were variations from baseline of steroid hormones: total T, free T (f T), and estradiol (E). Secondary endpoints were variations of erectile function domain scores at International Index of Erectile Function-5 (IIEF-5).

Methods. In an open-label fashion, 20 patients (mean age 54.8 ± 8.4 years) received tadalafil 10–20 mg on demand for 12 months. Exclusion criteria were those reported for phosphodiesterase inhibitors, including hypogonadism and hyperprolactinemia.

Results. Tadalafil assumption was safe and well tolerated (overall adverse effects in 15% of patients) and none discontinued medication. A significant decrease in E levels occurred at the end of the study (from 19.9 ± 9.6 to 16.6 ± 8.1 ng/dL, P = 0.042 vs. baseline), with parallel increase in the T:E ratio (26.3 ± 15.3 to 32.6 ± 17.7, P = 0.05), whereas no changes in T and f T serum levels were observed, respectively (411.4 ± 131.4 to 434.2 ± 177.1 ng/dL and 47.7 ± 15.3 to 49.9 ± 19.1 pmol/L, not significant). Interestingly, nonparametric subgroup analysis for related samples revealed that E decrease was detectable only in lean (N = 14) but not in obese (N = 6, body mass index > 27.5 kg/m2) subjects (17.8 ± 10.1 vs. 13.5 ± 6.8, P < 0.05). A net increase in IIEF-5 scores was observed at the endpoint (13.7 ± 5.9 vs. 25.7 ± 2.9, P < 0.0001).

Conclusions. Sustained improvement in sexual function after 12 months of tadalafil administration is associated with increased T:E ratio mainly related to reduction of E levels. We hypothesize that androgen–estrogen cross-talk and possible inhibition of aromatase activity during chronic exposure to tadalafil might have a role in the regulation of erectile function. Greco EA, Pili M, Bruzziches R, Corona G, Spera G, and Aversa A. Testosterone:estradiol ratio changes associated with long-term tadalafil administration: A pilot study. J Sex Med 2006;3:716–722.

Interesting. Wonder what "on demand" tx represents? Daily for 12 months or as needed? Also of interest, changes were seen in lean but not obese men. That finding isn't surprising but still underscores the important relationship between fat and estrogen in men.

[kelkel]

Testosterone:Estradiol Ratio Changes Associated with Long-Term Tadalafil Administration: A Pilot Study

Keywords:
Phosphodiesterase Inhibitor;Steroid Hormones;Estradiol;Testosterone;Chronic Treatment;Aromatase

ABSTRACT
Introduction.  It has been reported that lack of sexual activity due to erectile dysfunction (ED) may be associated with testosterone (T) decline.

Aim.  To investigate whether the known changes in sex hormones associated with resumption of sexual activity are sustained in the long term.

Main Outcome Measures.  Primary endpoints were variations from baseline of steroid hormones: total T, free T (f T), and estradiol (E). Secondary endpoints were variations of erectile function domain scores at International Index of Erectile Function-5 (IIEF-5).

Methods.  In an open-label fashion, 20 patients (mean age 54.8 ± 8.4 years) received tadalafil 10–20 mg on demand for 12 months. Exclusion criteria were those reported for phosphodiesterase inhibitors, including hypogonadism and hyperprolactinemia.

Results.  Tadalafil assumption was safe and well tolerated (overall adverse effects in 15% of patients) and none discontinued medication. A significant decrease in E levels occurred at the end of the study (from 19.9 ± 9.6 to 16.6 ± 8.1 ng/dL, P = 0.042 vs. baseline), with parallel increase in the T:E ratio (26.3 ± 15.3 to 32.6 ± 17.7, P = 0.05), whereas no changes in T and f T serum levels were observed, respectively (411.4 ± 131.4 to 434.2 ± 177.1 ng/dL and 47.7 ± 15.3 to 49.9 ± 19.1 pmol/L, not significant). Interestingly, nonparametric subgroup analysis for related samples revealed that E decrease was detectable only in lean (N = 14) but not in obese (N = 6, body mass index > 27.5 kg/m2) subjects (17.8 ± 10.1 vs. 13.5 ± 6.8, P < 0.05). A net increase in IIEF-5 scores was observed at the endpoint (13.7 ± 5.9 vs. 25.7 ± 2.9, P < 0.0001).

Conclusions.  Sustained improvement in sexual function after 12 months of tadalafil administration is associated with increased T:E ratio mainly related to reduction of E levels. We hypothesize that androgen–estrogen cross-talk and possible inhibition of aromatase activity during chronic exposure to tadalafil might have a role in the regulation of erectile function. Greco EA, Pili M, Bruzziches R, Corona G, Spera G, and Aversa A. Testosterone:estradiol ratio changes associated with long-term tadalafil administration: A pilot study. J Sex Med 2006;3:716–722.

I'm still stunned that androgens and estrogens can talk! Maybe that explains the voices in my head? Wait.....what?

[MuscleInk]

I'm still stunned that androgens and estrogens can talk! Maybe that explains the voices in my head? Wait.....what?

The only real friends I have are the voices in my head.

[jimmyinkedup]

^^Leave us alone ....

[junk2222yard]

Yet another good reason to take Cialis (Tadalafil) each day...

I am now on the tadalafil program! Thing is, if I take 5mg or more, I get very strong heart burn; something I rarely experience normally. Greater than 5mg means other side effects like headache and nasal issues, and even worse heartburn.

So for now I am on a 1x/day 2.5mg dose, hoping I can ramp up to 5mg or 10mg slowly and avoid the sides.

Has anyone "been there/done that" who can confirm after prolonged use or a slow ramp up, the side effects fade or dissipate altogether?

[steroid.com 1]

I am now on the tadalafil program! Thing is, if I take 5mg or more, I get very strong heart burn; something I rarely experience normally. Greater than 5mg means other side effects like headache and nasal issues, and even worse heartburn.

So for now I am on a 1x/day 2.5mg dose, hoping I can ramp up to 5mg or 10mg slowly and avoid the sides.

Has anyone "been there/done that" who can confirm after prolonged use or a slow ramp up, the side effects fade or dissipate altogether?

As I have advised, take it just before bed and most of any symptoms will not be felt.

Your body will acclimate over a short period of time and all of these symptoms will subside.

Hell, 20 mg of Viagra would give me the worst nasal pressure...now not a thing.

You'll adjust, trust me

[junk2222yard]

Thanks gd,
I will try that.

[dreadnok89]

Hey gd. If i dont have a prob with erections, would it give me the prolonged ones?

[Moparman]

I got 30 troche of tadalafil at 25mg each. Was told to take 1/4 troche 30 min before workout. I was getting mild headaches and indigestion for the first 3 times I took it but not really the 4th.

So I take it every other day. About 6 Mgs. Does it do anything more if I take it every day. I'm just trying to drive blood into my muscles

[steroid.com 1]

Hey gd. If i dont have a prob with erections, would it give me the prolonged ones?

You will be fuller when relaxed (not a bad thing), you will get an erection much faster and will sustain it longer...but you must be sexual aroused in order for the erection to happen.

You will look great in the gym and afterwards as well if you like that hard muscular vascular look...and I do as Tadalafil has a long half life like 16 hours plus.

Kel looks sic, just check out his avi LOL!

[steroid.com 1]

I got 30 troche of tadalafil at 25mg each. Was told to take 1/4 troche 30 min before workout. I was getting mild headaches and indigestion for the first 3 times I took it but not really the 4th.

So I take it every other day. About 6 Mgs. Does it do anything more if I take it every day. I'm just trying to drive blood into my muscles

One needs to consider half life of the drug which I mentioned is 16 hours or so. So an EOD dosage is not keeping your serum levels stable.

I would titrate the drug till your system gets used to it. Start with 2 mg daily and then every 7 days increase 1 mg till you to your 6mg daily...that will do it for you.

[Moparman]

I didn't get the headache or indigestion from the dose I took yesterday. So maybe I am acclimating

[steroid.com 1]

I didn't get the headache or indigestion from the dose I took yesterday. So maybe I am acclimating

Probably...remember these are low doses to begin with.

You'll get used to it.

[dreadnok89]

Perfect GD! The last thing i need is doctors poking around at my little erection. I am already getting tadafil 10 mg capsules