Supraphysiological testosterone long term risk

[Rob13]

Please educate me, what are the risks of supraphysiological free test long term.
I ask because I am on TRT, and I saw a post and a comment was made regard it being a risk to have free test high for too long. I posted labs below.

Last labs in January
SHGB 22 standard range 10-55
Free test 32.27 no std range given
Hemocrit 47.9 std 37-49
Test 1327 std 200-1000
Estradiol 5 std 0.5-5

Oct of 2012 Results
LH .51 std 6-19
Follicle SH .35 std 4-10
DHEA-S 3612 std 427-2243
SHGB 16 std 10-55
Free test 45.62
Hemoglobin 16.1 std 13-17
Hemocrit 47.1 std 37-49
Prolactin 11 std 3-30
Dihydrotesosterone 647 std 106-719

This was a non fasting test
Chol 227 std <200
Tri 420 <150
HDL 48 std >39
LDL could not be calculated due to tri over 400

[steroid.com 1]

Low or even low normal Testosterone serum levels makes the Lipid Profile and insulin sensitivity worse...not good stuff.

As Testosterone serum levels increases and gets within the healthy range Lipid Profile and insulin sensitivity improves...good stuff!

When a man passes through the top of normal healthy range the Lipid Profile falls off again and insulin sensitivity turns to insulin resistance...not good stuff.

The same goes for sexual function. There are men who have reported that when they dialed down their high Testosterone serum levels only to find that their libido resumed to awesome levels.

Here's a good thread on just the subject: http://forums.steroid.com/hormone-re...l#.UWWuLpPktqU

[The Deadlifting Dog]

My guesses:

High blood pressure
High estrogen
High LDL/ low HDL
High hematocrit (blood too thick)
High PSA

Just to name a few off the top of my head.

[Rob13]

BP, hemocrit, PSA, and HDL, are all in normal range. Trig. Are jacked up due to it not being a fasting test

[Rob13]

Thanks gdevine

[powerlifterty16]

i thought raising test even into the normal range increases cholesterol. By lipids you mean chol. right?

[steroid.com 1]

When total testosterone is supraphysiologic, at lets say over 1000 ng/dl, men will experience problems with libido, erection quality and poor orgasm intensity.

Testosterone increases Dopamine in the brain and we hear men all the time who were once hypogonadal say that when they started their TRT protocols they "never felt better in years and their libido is through the roof"!

So, testosterone replacement in hypogonadal men initially will increase sex drive, reduces depression and gives pleasure to many activities. But it's short lived unfortunately as the brain (Dopamine receptors) settles down to the now normal physiological Dopamine levels

The problem is that Dopamine is a very fragile neurotransmitter/hormone in its effect on the brain.

Too high a Dopamine level for sustained periods of time can cause a tolerance or "numbing" to Dopamine. This is not too dissimilar to how people develop tolerance to drugs like cocaine and amphetamines which increase Dopamine levels in the brain to cause their "high" if you will.

This can lead to the loss of libido, ability to maintain an erection and lower orgasm intensity when high testosterone levels are maintained for long periods of time.

This is just one of many things that come to mind when we talk about sustained elevated levels of Testosterone in men.

[ironbeck]

When total testosterone is supraphysiologic, at lets say over 1000 ng/dl, men will experience problems with libido, erection quality and poor orgasm intensity.

Testosterone increases Dopamine in the brain and we hear men all the time who were once hypogonadal say that when they started their TRT protocols they "never felt better in years and their libido is through the roof"!

So, testosterone replacement in hypogonadal men initially will increase sex drive, reduces depression and gives pleasure to many activities. But it's short lived unfortunately as the brain (Dopamine receptors) settles down to the now normal physiological Dopamine levels

The problem is that Dopamine is a very fragile neurotransmitter/hormone in its effect on the brain.

Too high a Dopamine level for sustained periods of time can cause a tolerance or "numbing" to Dopamine. This is not too dissimilar to how people develop tolerance to drugs like cocaine and amphetamines which increase Dopamine levels in the brain to cause their "high" if you will.

This can lead to the loss of libido, ability to maintain an erection and lower orgasm intensity when high testosterone levels are maintained for long periods of time.

This is just one of many things that come to mind when we talk about sustained elevated levels of Testosterone in men.

X2...too much of anything is bad.

[38onTRT]

Good info here!

[Rob13]

Gdevine
Good info, do you have any info on frequency and duration someone should come off test? My doc has me coming off for a month in July.
Will low dose hcg help with this issue or does it require coming off test?
I sent my doc a message referencing a study you referred to in a link that you sent me last week (from another thread). I asked him if low dose hcg would be appropriate for me. I have not heard back from him.

[steroid.com 1]

Gdevine
Good info, do you have any info on frequency and duration someone should come off test? My doc has me coming off for a month in July.
Will low dose hcg help with this issue or does it require coming off test?
I sent my doc a message referencing a study you referred to in a link that you sent me last week (from another thread). I asked him if low dose hcg would be appropriate for me. I have not heard back from him.

You should NEVER come off your testosterone therapy unless there was another more serious medical condition like an androgen dependent malignancy.

Your Doctor doesn't know what he's doing.

You should be on HCG for all the reasons noted in the sticky.

[Rob13]

Will read when I get home thanks!

Can you recommend a VERY basic book, something like "TRT for dumb asses" because this is confusing. Something to give me a base of knowledge so when I read studies I don't feel like I need to put on a styrofoam helmet and lick windows.

[steroid.com 1]

Nelson Vergel's book: Testosterone: A Man's Guide

I got this link for you because you are showing an interest in learning and I like that a lot

I know Nelson, he's a laymen and highly self educated and respected in the HRT medical community...good dude to boot, a real advocate for men's health and I like that as well.

Enjoy: Testosterone: A Man's Guide- Second Edition: Nelson Vergel: Amazon.com: Kindle Store

[Rob13]

I ordered the book, looking forward to reading it.

Thank you!