At 120mg/week (test cyp), E2 went from 32.6 (week 2) to 69.8 (week 7)

[jwhit84]

I take 60mg every 3.5 days, and my E2 is right around 70 as of yesterday. Total T is 1118.

Week 2 - 816 total T, 32.6 E2
Week 7 - 1118 total T, 69.8 E2

I have an AI, so I am considering .25mg of the AI 2x/week (each one taken 24 hours after injection). I don't want to start too high and tank my E2, so would this be a good starting point? Also, I haven't really noticed any bad effects out of the ordinary, but I still would like it to be in the normal range. The only possible effect is lower energy, but it's still much better than before the TRT. Maybe I'm retaining some extra water, but it's nothing crazy.

Thanks

[jwhit84]

Any suggestions on how much Arimidex to start? .5 twice a week or .25 twice a week?

[Bio-Active]

.25 eod is a good starting point and adjust from there

[FRDave]

I take 60mg every 3.5 days, and my E2 is right around 70 as of yesterday. Total T is 1118.

Week 2 - 816 total T, 32.6 E2
Week 7 - 1118 total T, 69.8 E2

I have an AI, so I am considering .25mg of the AI 2x/week (each one taken 24 hours after injection). I don't want to start too high and tank my E2, so would this be a good starting point? Also, I haven't really noticed any bad effects out of the ordinary, but I still would like it to be in the normal range. The only possible effect is lower energy, but it's still much better than before the TRT. Maybe I'm retaining some extra water, but it's nothing crazy.

Thanks

I personally would lower test dosage and get your levels back down to 750-800 and you should be good to go with no AI like in week 2.

[Vettester]

Was your E2 lab noted as a "sensitive" assay? Can you post the ranges? If that is a sensitive score, I would talk to your doctor about going .25 x2/wk on the AI.

I agree with the advice above about lowering your test dosage. Look at SubQ, smaller, frequent dosages, which will also help you manage your E2 more effectively.

[Vettester]

Also, would like to see your free test if you have it, and/or SHBG and Albumin.

[kelkel]

I personally would lower test dosage and get your levels back down to 750-800 and you should be good to go with no AI like in week 2.

Great advice from FRDave! Op you won't feel any difference if you drop your T level down a bit. It really is a plus to not have to use an AI! Please answer Vette's questions too.

[xcraider37]

I take 60mg every 3.5 days, and my E2 is right around 70 as of yesterday. Total T is 1118.

Week 2 - 816 total T, 32.6 E2
Week 7 - 1118 total T, 69.8 E2

I have an AI, so I am considering .25mg of the AI 2x/week (each one taken 24 hours after injection). I don't want to start too high and tank my E2, so would this be a good starting point? Also, I haven't really noticed any bad effects out of the ordinary, but I still would like it to be in the normal range. The only possible effect is lower energy, but it's still much better than before the TRT. Maybe I'm retaining some extra water, but it's nothing crazy.

Thanks

Another thing that needs to be considered is what E2 test is giving you these results?

Is it a sensitive test, which generally will give a lower number.

[jwhit84]

Was your E2 lab noted as a "sensitive" assay? Can you post the ranges? If that is a sensitive score, I would talk to your doctor about going .25 x2/wk on the AI.

I agree with the advice above about lowering your test dosage. Look at SubQ, smaller, frequent dosages, which will also help you manage your E2 more effectively.

It's not the sensitive assay, but I think it's pretty reliable based off my results (the rise after starting T, and the fall after starting AI). I took the advice and lowered my dosage from 120/week to 100/week (50 ml twice/week). I also added in 0.25 anastrozole 24 hours after each injection (0.5 mg / week total). Here are my latest lab results after a few weeks on this routine:

Testosterone , Total, LC/MS 1055.7 ng/dL (348.0-1197.0)
Free Testosterone(Direct) 36.0 High pg/mL (9.3-26.5)
Estradiol 42.7 High pg/mL (7.6-42.6)
Sex Horm Binding Glob, Serum 20.2 nmol/L (16.5-55.9)

I'm feeling good at these levels, but I'm wondering if I should try 1mg AI instead of 0.5 since I'm at 42.7 E2. Wouldn't 20-30 range be better? Thanks!

[Trific]

The E2 might still be going down slowly on that dose plus you lowered the test and you're feeling good so personally I wouldn't change anything.

[bass]

Greta advise by FRDave! I think 0.25 mgs twice a week will crash your e2 pretty fast and you wont like it, not to mention the other sides like high RBC, Hemoglobin and Hematocrit. if you decide on taking it then no more that 0.25 once a week. but lowering your T dose is the key here, that free T really needs to come down.

[jwhit84]

Greta advise by FRDave! I think 0.25 mgs twice a week will crash your e2 pretty fast and you wont like it, not to mention the other sides like high RBC, Hemoglobin and Hematocrit. if you decide on taking it then no more that 0.25 once a week. but lowering your T dose is the key here, that free T really needs to come down.

Hey, did you happen to see my most recent update today? I lowered to 100mg / week (total) and started 0.25 mg AI 2x/week. It's been 4 1/2 weeks of this, and I posted my lab work from last week a couple of posts up.

It seems like I have seen a lot of people's lab work show Free T above the range, but I thought that was a good thing. What are the negative effects of that? Thanks for the reply!

[FRDave]

Hey, did you happen to see my most recent update today? I lowered to 100mg / week (total) and started 0.25 mg AI 2x/week. It's been 4 1/2 weeks of this, and I posted my lab work from last week a couple of posts up.

It seems like I have seen a lot of people's lab work show Free T above the range, but I thought that was a good thing. What are the negative effects of that? Thanks for the reply!

Like myself, you can probably drop test to 80mg per week and sit in the mid 800 range on total test, which will probably be perfect for your e2 levels, keeping arimidex the same at .25mg 2x per week.

I am not sure of the negative effects of free test being high and am interested myself as I hear this often :-/

[bass]

Hey, did you happen to see my most recent update today? I lowered to 100mg / week (total) and started 0.25 mg AI 2x/week. It's been 4 1/2 weeks of this, and I posted my lab work from last week a couple of posts up.

It seems like I have seen a lot of people's lab work show Free T above the range, but I thought that was a good thing. What are the negative effects of that? Thanks for the reply!

The high rbc, hemo and hema comment are the sides of high T. But there are other hormones to worry about like shbg crashing, dht, Lipid Panel, liver...

[jwhit84]

The high rbc, hemo and hema comment are the sides of high T. But there are other hormones to worry about like shbg crashing, dht, Lipid Panel, liver...

I gotcha, thanks. So do you think I should try reducing further to 80 mg/week and test again in 4-6 weeks?