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  1. #1
    GeriatricOne's Avatar
    GeriatricOne is offline Associate Member
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    Can TRT cause liver enzymes to sky rocket?

    Blood work came back with liver enzymes more than 200 points above the upper range!

    Had a bad kidney stone situation a couple of weeks ago. Urologist took blood at the time. Returned for post-op follow-up today. Blood work results revealed the off-the-charts liver enzymes. The doctor said the TRT could be a factor and wants me to see my TRT doctor right away.

    I take 150mg Test bi-weekly
    .5mg anastrozole
    250 HCG bi-weekly

    Anyone know of cases of TRT impacting liver function like this?

    I have not consumed alcohol in over 10 years.

  2. #2
    bass's Avatar
    bass is offline HRT Specialist ~ Knowledgeable Member
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    not unless you use oral aas or high dose injections. 150 bi-weekly is a terrible protocol unless you mean once a week! your elevated liver enzymes probably the results of pain killers they gave you for the kidney stone. once you stop pain killers and oral medications do another BW 4 weeks after, if enzymes go down then you're fine.

    TRT at your dose will have zero effect on your liver unless you have pre existing liver cancer.

  3. #3
    FRDave's Avatar
    FRDave is offline Senior Member
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    My liver values have gone up a few points since I started TRT but nothing out of the normal range. I started taking 600mg on NAC daily a good 4 weeks back and just got blood work this morning, so I'll see if it helps at all.

  4. #4
    GeriatricOne's Avatar
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    Sorry, I meant 150 divided into 75mg bi-weekly doses.
    I was thinking today about all the hydrocodone and antibiotics I was taking for a week prior to that blood test. Makes sense those would the the liver stressors.

    Thanks for the replies!

  5. #5
    APIs's Avatar
    APIs is offline Knowledgeable Member
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    Quote Originally Posted by GeriatricOne View Post
    Sorry, I meant 150 divided into 75mg bi-weekly doses.
    I was thinking today about all the hydrocodone and antibiotics I was taking for a week prior to that blood test. Makes sense those would the the liver stressors.

    Thanks for the replies!
    Bass is right. Acetaminophen is typically added to Hydrocodone & in pretty high doses. Even a weeks worth of taking this can elevate liver values significantly in some people. I've experienced this myself...

  6. #6
    kelkel's Avatar
    kelkel is offline HRT Specialist ~ AR-Platinum Elite-Hall of Famer ~ No Source Checks
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    Consider adding NAC to your protocol or UDCA if you doc will write it for you. NAC is OTC and just fine. You can get it at any drug store / vitamin shop.
    -*- NO SOURCE CHECKS -*-

  7. #7
    LowT Mike is offline HRT Specialist, P.A. - LowTestosterone.com
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    ^^^^Bass is right. Injectable T goes throgh first pass of liver and if your using Cypionate or Enanthate it is Bioidentical to bodies own natural testosterone so no extra carbon polymers are cleft off during metabolism. Inappropriate TRT doses, Oral and some nonbio AAS would raise Liver Enzemes.

  8. #8
    GeriatricOne's Avatar
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    Thanks for the replies guys. My TRT blood work comes around again in 3 weeks. I notified the doctor's office to add the liver tests. Until then I will detox...

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