Estrogen's inpact on insulin sensitivity.

[LowT Mike]

This unexpected finding suggests that estrogen may have independent effects on insulin sensitivity. If estrogen indeed has an independent regulatory role in this regard, this would suggest that aromatase conversion of testosterone to estrogen in men could be important in the effects of testosterone on insulin sensitivity. In addition, this would be consistent with the important role already demonstrated for estrogen on bone metabolism and with the metabolic effects observed in aromatase deficient males.

Effect of Testosterone and Estradiol on Insulin Sensitivity in Healthy Older Men -- Lee et al. 34 (3): SUN-799 -- Endocrine Reviews

[rt12008]

This is very interesting. Is low E and issue? I seem to go between 8-10 no matter how much T I take. If it is low, how does one increase it if the body won't?

You are awesome LowT Mike. I read every post you put on here.

[LowT Mike]

Thank you for the kind words. Im here to help. I know how frustrating it can be trying to find a good TRT doc. Yes. Low E is a problem. If E2 drops to 0 very bad for endothilial layer inside blood vessels that surround the heart and brain. Generally levels between 20-30pg/ml is ideal.

[m_donnelly]

I can tell you from personal experience that high estrogen causes insulin resistance.

I had a difficult time controlling my blood sugar before TRT (test levels at 250). I was put on TRT, it helped with my blood sugar significantly until my estrogen started to spike. It was one of the first indications that my E2 was high.

[rt12008]

Thank you for the kind words. Im here to help. I know how frustrating it can be trying to find a good TRT doc. Yes. Low E is a problem. If E2 drops to 0 very bad for endothilial layer inside blood vessels that surround the heart and brain. Generally levels between 20-30pg/ml is ideal.

So how do you raise it if it is low?

[kelkel]

Are you taking any supplements that may impact it?

DHEA supplementation may help to raise your E slightly.

[rt12008]

What is an example of a few of those supplements? It is possible.

My dhea is above range on my tests.

[rt12008]

This paper on what supplements might do it is too long!

Natural Products as Aromatase Inhibitors

[rt12008]

aromatase inhibitors

So I supplement with onion, garlic, and kale. I wonder if that is enough to keep me at 10 or under.

Kelkel?

[kelkel]

Stop and see. You'll probably have more friends hanging around when you do!

[rt12008]

Stop and see. You'll probably have more friends hanging around when you do!

Hahaha. Dude. Is that why I have no friends?!? Fair point. I will back off the friend repellent and see if my estrogen also goes up.