Endo Review: The average dose of Vitamin D is not enough for some patients

[austinite]

Evaluation of Response to Treatment with 50,000 IU of Vitamin D3 in Deficient Patients

Background: Inadequate vitamin D status has been associated with an increased risk of several diseases, including osteoporosis, cardiovascular disease, diabetes, cancer, multiple sclerosis and infections. Serum 25-hydroxyvitamin D is the classic marker of vitamin D status and is determined by environmental (season, latitude, sunlight, diet), demographic (ethnicity, body mass index) and genetic (polymorphism in metabolism and transport genes) factors. (1) However, the features that modify the response to vitamin D supplementation remain unclear. The Endocrine Society suggests the use of 50,000 IU of vitamin D2 or D3 weekly over eight weeks for the treatment of deficient adults to achieve a blood level of 25-hydroxyvitamin D above 30 ng/mL. (2)

Objective: The aim of the present study was to evaluate the response to supplementation with 50,000 IU of vitamin D3 in deficient patients.

Patients and Methods: Twenty-five osteoporotic female patients with vitamin D deficiency (25-hydroxyvitamin D < 20 ng/ml) received eight capsules of 50,000 IU of vitamin D3 for treatment. All capsules were manufactured at the same place. The patients were instructed to take one capsule a week for eight weeks. All patients reported appropriate adherence to treatment and none reported any gastrointestinal problems.

Results: After treatment, serum levels of 25-hydroxyvitamin D were reevaluated. More than half of the patients (13/25) did not achieve the levels recommended by the Endocrine Society (> 30 ng/ml). Both groups of patients (successful treatment and unsuccessful treatment) had similar body mass index values and initial pretreatment levels of 25(OH)-vitamin D. The group with the worse response was older.

Discussion: A number of authors have reported considerable inter-individual variation in serum 25-hydroxyvitamin D response to supplementation with identical doses. In the present study, this variation was found using the dose recommended by the Endocrine Society. The data suggest that the standard dose may not be enough to treat all patients and that reevaluation of vitamin D levels after treatment should always be considered.

http://edrv.endojournals.org/cgi/content/meeting_abstract/33/03_MeetingAbstracts/MON-350

[Java Man]

Nice writeup, as.usual!

[austinite]

Nice writeup, as.usual!

lol. Nice COPY you mean ...

http://edrv.endojournals.org/cgi/content/meeting_abstract/33/03_MeetingAbstracts/MON-350

[bass]

it was by accident that I found out I needed high doses vit. D to be effective. my wife simply picked up a bottle that was dosed at 20,000ius per gelcap daily, took it for a month or so and the test came back perfect!

[dreadnok89]

I thought woman were more prone to vitamin D probs?

[powerlifterty16]

i dont see ho one 50iu weekly is better than 10k every day for 8 weeks..or forever.

[powerlifterty16]

it was by accident that I found out I needed high doses vit. D to be effective. my wife simply picked up a bottle that was dosed at 20,000ius per gelcap daily, took it for a month or so and the test came back perfect!

bass what's the brand i may try those for a month or two jsut for shits and giggles.

[bass]

bass what's the brand i may try those for a month or two jsut for shits and giggles.

walmart brand! Sam's club sells them too. lots of them,very cheap and very effective! results backed by BW.

[FRDave]

12000iu daily (Now branded) has me in the mid 80's on a scale or 30-100 ng/dL. Originally I was at 28 ng/dL.

[HRTstudent]

i dont see ho one 50iu weekly is better than 10k every day for 8 weeks..or forever.

the prescription (i.e. big pharma money and being used in research) form of vitamin D (drisdol) is commonly given as a single tablet of 50k IU because patients are more likely to take 1 pill a week than a pill every day. think what you will, but patient compliance is a very real part of treatment -- many people who would do better, know how to do better, and are able to do better... simply don't do better because they don't take their prescriptions.

regular vitamin D is not patentable so you are not likely to see as much big money and research going into it.

[powerlifterty16]

the prescription (i.e. big pharma money and being used in research) form of vitamin D (drisdol) is commonly given as a single tablet of 50k IU because patients are more likely to take 1 pill a week than a pill every day. think what you will, but patient compliance is a very real part of treatment -- many people who would do better, know how to do better, and are able to do better... simply don't do better because they don't take their prescriptions.

regular vitamin D is not patentable so you are not likely to see as much big money and research going into it.

yeah i guess for lazy people it works, but istill think 10k every day would be better....plus id imagine you'd need a more fatty meal to absorb the 50k

[Moparman]

I take 10,000 iu d3 5 days a week and 50,000 iu d2 twice a week and I'm in mid 80s. Scale 30-100

[kelkel]

12000iu daily (Now branded) has me in the mid 80's on a scale or 30-100 ng/dL. Originally I was at 28 ng/dL.

I take 10,000 iu d3 5 days a week and 50,000 iu d2 twice a week and I'm in mid 80s. Scale 30-100

You guys have nailed it!