Considering that secondary is caused by the brain and primary is caused by the testes, is there any difference in how trt should affect my body or blood levels? I have a prolactinoma which prevents my pituitary from secreting enough T, my testes are working fine apparently. Ive had it since the beginings of my puberty stages id say.

so, I guess specifically im curious about two things. Will my t and e2 levels be affected differently with trt than someone with primary? I know most people experience spikes in e2 after starting trt. Is it possible I wont experience that or is the cause of low t irrelevent here? My doc didnt want me on adex and was pretty adiment that my e2 wouldnt get out of control. Secondly, should I expect a more dramatic physical change, considering my pituitary hasnt functioned correctly since before puberty?

Thanks guys.