TRT Increases Your Risk of Prostate Cancer...Right? False

We get this one a lot. Just 3 years ago on the boards people were still telling people "testosterone fuels prostate cancer man be careful!"

Well the truth is that it does not. In the most recent retrospective study of almost 40,000 men the authors even noted "how the testosterone was used or monitored had no effect"

So where's the beef? Save your time fellas its all chicken......verdict is in :haha:

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"Based on our findings, physicians should still be watching for prostate cancer risk factors—such as being over the age of 40, having African-American ancestry, or having a family history of the disease—in men taking testosterone therapy, but should not hesitate to prescribe it to appropriate patients for fear of increasing prostate cancer risk."

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"Overall, our study suggests that what is best for men's health is to keep testosterone levels balanced and within a normal range," says Loeb, who suggests that men with testosterone levels below 350 nanograms per deciliter and symptoms should seek medical advice about whether they should consider testosterone therapy."

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Wanna get the details on this? Click the image below:

https://s31.postimg.org/9qhdvercb/Sc...0_36_32_AM.png

Let us know what you think below!

This is correct. For a long time physicians were afraid of prescribing testosterone due to this misconception.

Still, while there is no data suggesting higher prostate cancer incidence related to testosterone, TRT is absolutely contraindicated in existing prostate cancer patients, so it should be mandatory prostate cancer screenning for prospective TRT patients, in a effort to rule out occult cancers.

"There is evidence, however, that testosterone will stimulate the growth of existing prostatic cancers and, of course, existing prostate cancer is contraindicated for testosterone therapy" , from: A practical guide to male hypogonadism in the primary care setting, P Dandona and M T Rosenberg

Recommended baseline assessments are voiding function or history; digital rectal exam (DRE); serum testosterone level; prostate-specific antigen (PSA) testing with prostate biopsy if PSA is > 4.0 ng/mL, if it increases substantially over a short period, or DRE is abnormal; history of sleep apnea; and hematocrit or hemoglobin.[6]
Clinicians should monitor PSA levels and perform a DRE regularly while the man is receiving treatment because of prostate cancer concerns. The clinical response of testosterone should be evaluated at 3 months and 1 year. A DRE and prostate symptomatology should be assessed every 6 to 12 months. Before TRT, a baseline PSA should be measured. After TRT, the PSA should be measured quarterly during the first year, then annually. Regardless of baseline PSA, an increase ≥ 4.0 ng/mL or rapidly increasing PSA levels are widely accepted criterion for urologic referral or prostate biopsy. from: L0w Testosterone, Todd M. Tartavoulle, MN, RN; Demetrius J. Porche, DNS, PhD

First of all your real small study (one person :)) was done in 2012. Our information is from 2016.

If you take the time to read the study they clearly explain the difference of some growth and OVERALL risk.

It sounds like you may not be understanding the difference.

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Researchers noted that while their initial analysis showed an uptick (of 35 percent) in prostate cancer in men shortly after starting therapy, the increase was only in prostate cancers that were at low risk of spreading and was likely a result from more doctor visits and biopsies performed early on. The authors stressed that the long-term reduction in aggressive disease was observed only in men after more than a year of testosterone use, and the risk of prostate cancer did not differ between gels and other types of preparations.

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Study suggests testosterone therapy does not raise risk of aggressive prostate cancer

SOOOOOOOO........

Men with prostate cancer risk should be screened regardless of TRT. My point is TRT does not change anything.

The fact is there was no increased risk, and of note aggressive risk dropped by 50%.

and KABLAM......to take it one step further.

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"These results suggest low levels of testosterone are associated with more aggressive prostate cancer. This contradicts long-held beliefs that high testosterone is risky for prostate cancer, and low testosterone is protective," said Dr. San Francisco.

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Low testosterone levels may indicate worsening of disease for men with prostate cancer

Hey you know how those men who were running 200 on the 10 week schedule? Wonder what that does for prostate risk?

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Originally Posted by IncreaseMyT

First of all your real small study (one person :)) was done in 2012. Our information is from 2016.

If you take the time to read the study they clearly explain the difference of some growth and OVERALL risk.

It sounds like you may not be understanding the difference.



Study suggests testosterone therapy does not raise risk of aggressive prostate cancer

SOOOOOOOO........

Men with prostate cancer risk should be screened regardless of TRT. My point is TRT does not change anything.

The fact is there was no increased risk, and of note aggressive risk dropped by 50%.

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Dude, we are saying the same, the only thing I'm adding is that TRT is contraindicated in EXISTING prostate cancer patients.

Let me say this again to make it clear, TRT DOES NOT INCREASE THE NUMBER OF NEW CASES OF PROSTATE CANCER, BUT IF ALREADY HAVE PROSTATE CANCER TESTOSTERONE IS CONTRAINDICATED

Not sure thats true either based on the post above.

Listen I am not trying to put you down in any way, we know you are extremely knowledgable and valuable to the board, just justifying our reasoning that you did not agree with.

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Originally Posted by IncreaseMyT

First of all your real small study (one person :)) was done in 2012. Our information is from 2016.

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What are you talking about?? One person?? I quoted papers not studies.

And your link is an article from Medical Press, not an actual study, still, it never mentions existing prostate cancer patients or contraindications.

And BTW, you posted links to one of your competitors lol... maybe you should fix it :1laugh:

I am not responding to this thread further until you read the info BB, its all there.

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Specifically, the current study found that 38,570 of the men whose records were examined developed prostate cancer between 2009 and 2012. Of these men, 284 had prescriptions for testosterone replacement therapy before they were diagnosed with prostate cancer. Their records were compared with 192,838 men who did not develop prostate cancer, of whom 1,378 had used testosterone therapy.

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Originally Posted by IncreaseMyT

I am not responding to this thread further until you read the info BB, its all there.

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Ive read it before, but as english is not my mother language maybe you can explain it to me :)

Its actually very simple I have highlighted all the points that are relevant to our discussion:

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After following 154 men with low-risk prostate cancer for 38 months, the investigators found that low levels of free testosterone were significantly linked with an increased risk of developing more aggressive disease.

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Low testosterone levels may indicate worsening of disease for men with prostate cancer

wasn't this concluded years ago that estrogen is the one to watch out for when it comes to prostate cancer, and that they fond high estrogen low testosterone in most patients with prostate cancer?

I don't think it was concluded but I think you are spot on :)

Mr BB

IMT <---- not reckless :bbsmile:

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Originally Posted by IncreaseMyT

Its actually very simple I have highlighted all the points that are relevant to our discussion:

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WTF, thats a different link and phrase?!?!?

This is related to a different type of prostate cancer and its from 2014.

Its very confusing debating with you guys, you ask me to read one phrase, I ask to explain please and you bring another subject.

Maybe you should ask the contraindications to Dr. Matt and call it a day.

I have posted information regarding a retrospective study performed at NYU Longone Medical Center that clearly states that not only does TRT not increase your overall risk of prostate cancer it actually reduced risk of aggressive disease BY 50%.

This is from 2016

I posted, in an entirely different post, another study performed in 2014 that confirmed that men with low levels of testosterone actually had a SIGNIFICANT increase in aggressive disease.

So my point is what again is the contraindication?

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Originally Posted by IncreaseMyT

So my point is what again is the contraindication?

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Go ask Dr. Matt.

Discussing with sales reps is a waste of time.

Actually we would refer to our 17 year surgical and medical uro in NYC on this one.

Thanks for the discussion though.

It's not really testosterone we're talking about here anyway, it's DHT. The prostate reaches testosterone saturation at around 240 ng/dl if memory serves me correct (saturation model.). Beyond that it makes no difference.



Testosterone and prostate cancer: an evidence-based review of pathogenesis and oncologic risk

Shifting the paradigm of testosterone and prostate cancer: the saturation model and the limits of androgen-dependent growth. - PubMed - NCBI

http://www.europeanurology.com/artic...turation-model