Can iodine supplements affect estrodial?

[mazguy]

For the last year my protocol has been .5cc 200 cypionate every five days along with .5 Arimadex every four days.
My blood work regarding estrodial and testosterone has been steady and suddenly my testosterone spiked from 1000 to 1500 and estrodial dropped from 21 to 6. The only thing I did different was for the previous sixty days because of a high TSH number I starting taking 12 mgs a iodine supplement per day. Also I did the test six hours after taking my .5cc shot of cypionate followed by rigorous wrestling workout which might account for the 1500 testosterone spike? Usually I took my blood test the last day of my five-day testosterone cycle. I took the blood test on the same day as the shot just out of curiosity.

This was alarming so I immediately went off of the Arimadex and cut back on the iodine supplement to 1/2 of 12 mg pill every other day. Interesting though my TSH continues to rise. Is this something to worry about?

Test date 5/4/16 (This is the normal test)

CBC With Differential/Platelet
WBC 5.3 x10E3/uL 3.4 - 10.8 01
RBC 4.85 x10E6/uL 4.14 - 5.80 01
Hemoglobin 15.8 g/dL 12.6 - 17.7 01
Hematocrit 46.9 % 37.5 - 51.0 01
MCV 97 fL 79 - 97 01
MCH 32.6 pg 26.6 - 33.0 01
MCHC 33.7 g/dL 31.5 - 35.7 01
RDW 14.4 % 12.3 - 15.4 01
Platelets 204 x10E3/uL 150 - 379 01
Neutrophils 63 % 01
Lymphs 26 % 01
Monocytes 9 % 01
Eos 1 % 01
Basos 1 % 01
Neutrophils (Absolute) 3.4 x10E3/uL 1.4 - 7.0 01
Lymphs (Absolute) 1.4 x10E3/uL 0.7 - 3.1 01
Monocytes(Absolute) 0.5 x10E3/uL 0.1 - 0.9 01
Eos (Absolute) 0.1 x10E3/uL 0.0 - 0.4 01
Baso (Absolute) 0.0 x10E3/uL 0.0 - 0.2 01
Immature Granulocytes 0 % 01
Immature Grans (Abs) 0.0 x10E3/uL 0.0 - 0.1 01
Comp. Metabolic Panel (14)
Glucose, Serum 96 mg/dL 65 - 99 01
BUN 26 mg/dL 8 - 27 01
Creatinine, Serum 1.08 mg/dL 0.76 - 1.27 01
eGFR If NonAfricn Am 73 mL/min/1.73 >59
eGFR If Africn Am 84 mL/min/1.73 >59
BUN/Creatinine Ratio 24 High 10 - 22
Sodium, Serum 139 mmol/L 134 - 144 01
Potassium, Serum 4.9 mmol/L 3.5 - 5.2 01
Chloride, Serum 103 mmol/L 97 - 108 01
Carbon Dioxide, Total 24 mmol/L 18 - 29 01
Calcium, Serum 9.0 mg/dL 8.6 - 10.2 01
Protein, Total, Serum 6.1 g/dL 6.0 - 8.5 01
Albumin, Serum 4.2 g/dL 3.6 - 4.8 01
Globulin, Total 1.9 g/dL 1.5 - 4.5
A/G Ratio 2.2 1.1 - 2.5
Bilirubin, Total 0.9 mg/dL 0.0 - 1.2 01
Alkaline Phosphatase, S 78 IU/L 39 - 117 01
AST (SGOT) 28 IU/L 0 - 40 01
ALT (SGPT) 23 IU/L 0 - 44 01
Lipid Panel With LDL/HDL Ratio
Cholesterol, Total 176 mg/dL 100 - 199 01
Triglycerides 98 mg/dL 0 - 149 01
HDL Cholesterol 45 mg/dL >39 01
Comment 01
According to ATP-III Guidelines, HDL-C >59 mg/dL is considered a
negative risk factor for CHD.
VLDL Cholesterol Cal 20 mg/dL 5 - 40
LDL Cholesterol Calc 111 High mg/dL 0 - 99
LDL/HDL Ratio 2.5 ratio units 0.0 - 3.6
Please Note: 01
LDL/HDL Ratio
Men Women
1/2 Avg.Risk 1.0 1.5
Avg.Risk 3.6 3.2
2X Avg.Risk 6.2 5.0
3X Avg.Risk 8.0 6.1
Testosterone,Free and Total
Testosterone, Serum 1003 ng/dL 348 - 1197 01
Comment:
Adult male reference interval is based on a population of lean males
up to 40 years old.
Free Testosterone(Direct) 15.3 pg/mL 6.6 - 18.1 02
PSA Total+% Free
Prostate Specific Ag, Serum <0.1 ng/mL 0.0 - 4.0 01
Vitamin B12 and Folate
Vitamin B12 411 pg/mL 211 - 946 01
Folate (Folic Acid), Serum 12.1 ng/mL >3.0 01
Note: 01
A serum folate concentration of less than 3.1 ng/mL is
considered to represent clinical deficiency.
FSH and LH
LH <0.2 Low mIU/mL 1.7 - 8.6 01
FSH <0.2 Low mIU/mL 1.5 - 12.4 01
DHEA, Serum
Dehydroepiandrosterone (DHEA)
59 ng/dL 31 - 701 02
Age
1 - 5 years 0 - 67
6 - 7 years 0 - 110
8 - 10 years 0 - 185
11 - 12 years 0 - 201
13 - 14 years 0 - 318
15 - 16 years 39 - 481
17 - 19 years 40 - 491
>19 years 31 - 701
TSH 6.550 High uIU/mL 0.450 - 4.500 01
Estradiol
Estradiol 22.2 pg/mL 7.6 - 42.6 01
Roche ECLIA methodology
Please Note: 01
Information released to FDA by different reagent manufactures has
identified cross reactivity between Fulvestrant, a drug used in the
treatment of metastatic breast cancer, and immunoassays; leading to
falsely elevated estradiol results. Any patient known to be on a
Fulvestrant regimen can be tested for Estradiol using LabCorp assay
"Estradiol, Sensitive (LC/MS) test number 140244" which does not
exhibit Fulvestrant interference.
IGF-1
Insulin -Like Growth Factor I 158 ng/mL 49 - 188 02
Vitamin D, 25-Hydroxy 55.1 ng/mL 30.0 - 100.0 01
Vitamin D deficiency has been defined by the Institute of
Medicine and an Endocrine Society practice guideline as a
level of serum 25-OH vitamin D less than 20 ng/mL (1,2).
The Endocrine Society went on to further define vitamin D
insufficiency as a level between 21 and 29 ng/mL (2).
1. IOM (Institute of Medicine). 2010. Dietary reference
intakes for calcium and D. Washington DC: The
National Academies Press.
2. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al.
Evaluation, treatment, and prevention of vitamin D
deficiency: an Endocrine Society clinical practice
guideline. JCEM. 2011 Jul; 96(7):1911-30.
Estradiol, Sensitive 20.6 pg/mL 8.0 - 35.0 02
This test was developed and its performance characteristics
determined by LabCorp. It has not been cleared by the Food and
Drug Administration.
Methodology: Liquid chromatography tandem mass spectrometry(LC/MS/MS)
Thyroid Antibodies
Thyroid Peroxidase (TPO) Ab 13 IU/mL 0 - 34 01
Thyroglobulin Antibody <1.0 IU/mL 0.0 - 0.9 01
Thyroglobulin Antibody measured by Beckman Coulter Methodology




Test date 8/1/16

Vitamin D, 25-Hydroxy; Triiodothyronine,Free,Serum; Venipuncture
TESTS RESULT FLAG UNITS REFERENCE INTERVAL LAB
CBC With Differential/Platelet
WBC 11.6 High x10E3/uL 3.4 - 10.8 01
RBC 4.72 x10E6/uL 4.14 - 5.80 01
Hemoglobin 15.7 g/dL 12.6 - 17.7 01
Hematocrit 45.6 % 37.5 - 51.0 01
MCV 97 fL 79 - 97 01
MCH 33.3 High pg 26.6 - 33.0 01
MCHC 34.4 g/dL 31.5 - 35.7 01
RDW 14.1 % 12.3 - 15.4 01
Platelets 199 x10E3/uL 150 - 379 01
Neutrophils 87 % 01
Lymphs 7 % 01
Monocytes 6 % 01
Eos 0 % 01
Basos 0 % 01
Neutrophils (Absolute) 10.0 High x10E3/uL 1.4 - 7.0 01
Lymphs (Absolute) 0.8 x10E3/uL 0.7 - 3.1 01
Monocytes(Absolute) 0.7 x10E3/uL 0.1 - 0.9 01
Eos (Absolute) 0.0 x10E3/uL 0.0 - 0.4 01
Baso (Absolute) 0.0 x10E3/uL 0.0 - 0.2 01
Immature Granulocytes 0 % 01
Immature Grans (Abs) 0.0 x10E3/uL 0.0 - 0.1 01
Comp. Metabolic Panel (14)
Glucose, Serum 102 High mg/dL 65 - 99 01
BUN 29 High mg/dL 8 - 27 01
Creatinine, Serum 1.21 mg/dL 0.76 - 1.27 01
eGFR If NonAfricn Am 63 mL/min/1.73 >59
eGFR If Africn Am 73 mL/min/1.73 >59
BUN/Creatinine Ratio 24 High 10 - 22
Sodium, Serum 139 mmol/L 134 - 144 01
Potassium, Serum 4.9 mmol/L 3.5 - 5.2 01
Chloride, Serum 100 mmol/L 97 - 108 01
Carbon Dioxide, Total 21 mmol/L 18 - 29 01
Calcium, Serum 9.7 mg/dL 8.6 - 10.2 01
Protein, Total, Serum 6.5 g/dL 6.0 - 8.5 01
Albumin, Serum 4.4 g/dL 3.6 - 4.8 01
Globulin, Total 2.1 g/dL 1.5 - 4.5
A/G Ratio 2.1 1.1 - 2.5
Bilirubin, Total 0.6 mg/dL 0.0 - 1.2 01
Alkaline Phosphatase, S 73 IU/L 39 - 117 01
AST (SGOT) 23 IU/L 0 - 40 01
ALT (SGPT) 22 IU/L 0 - 44 01
Testosterone, Serum
Testosterone, Serum 1500 High ng/dL 348 - 1197 01
Results confirmed on
dilution.
Comment:
Adult male reference interval is based on a population of lean males
up to 40 years old.
Thyroxine (T4) Free, Direct, S
T4,Free(Direct) 0.89 ng/dL 0.82 - 1.77 01
TSH 10.770 High uIU/mL 0.450 - 4.500 01

Estradiol <6.0 Low pg/mL 7.6 - 42.6 01
Roche ECLIA methodology

Vitamin D, 25-Hydroxy 58.1 ng/mL 30.0 - 100.0 01
Vitamin D deficiency has been defined by the Institute of
Medicine and an Endocrine Society practice guideline as a
level of serum 25-OH vitamin D less than 20 ng/mL (1,2).
The Endocrine Society went on to further define vitamin D
insufficiency as a level between 21 and 29 ng/mL (2).
1. IOM (Institute of Medicine). 2010. Dietary reference
intakes for calcium and D. Washington DC: The
National Academies Press.
2. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al.
Evaluation, treatment, and prevention of vitamin D
deficiency: an Endocrine Society clinical practice
guideline. JCEM. 2011 Jul; 96(7):1911-30.
Triiodothyronine,Free,Serum 2.9 pg/mL 2.0 - 4.4 01

[kelkel]

Test will peak in 24 hrs or so metabolism dependent. You tested 6 hrs post injection so your T levels were rising. This accounts for the T spike. When it comes to your estrogen, when did you last take adex prior to the injection?

Further, you're testing estradiol which is geared for women and can read quite erroneously in men as it's not sensitive enough for accuracy. You should be testing with an E2 Sensitive Assay. Not sure I'd make any radical changes but it's always a great learning tool to test early in the protocol to see how things are.

No need to test LH & FSH when on TRT as they'll always be bottomed out. And what are you doing for your thyroid?

Edit as I forgot your actual question! No, I do not see where iodine would have any effect on your estrogen at all. It's just the timing as explained above.

[mazguy]

Thanks so much for the reply.
On the estrodial, the first test lists it as:
Estradiol, Sensitive 20.6 pg/mL 8.0 - 35.0 02
This test was developed and its performance characteristics
determined by LabCorp. It has not been cleared by the Food and
Drug Administration.
Methodology: Liquid chromatography tandem mass spectrometry(LC/MS/MS)

But the second test does not mention Sensitive so maybe the nurse who called in the BW failed to request Sensitive and that may have caused the erroneous number.
Estradiol <6.0 Low pg/mL 7.6 - 42.6 01
Roche ECLIA methodology

I thought because I use only sea salt without iodine that my levels were likely low. And after reading that a common cause high TSH was due to low iodine I'd try the supplement. Another function of iodine is said to be helping hormones work together more efficiently. That is why I suspected the iodine supplement could have affected the estrodial number.

I took the .5 adex three days before the blood test. I pin .5cc cyp 200 every five days and .5 adex every four. Would it be better to take adex same day as pinning testosterone ?

Took another blood test last Friday and now await the results--likely tomorrow. Hopefully someone ordered a sensitive test because I need to have my estrodial dialed in for a major competitive event this Friday. High estrodial causes a pronounced low level of aggression and too low puts me in danger of heart problems. I'm 64 but extremely fit.

For thyroid, doctor put me on Levothyroxine 50 mcg per day. But he was also concerned about my wbc.

1500 spike in testosterone is nothing to be concerned about?

[kelkel]

The estradiol sensitive 8-35 range is the correct test. 20 is a great level for most guys.
Yes, I'd take the adex the same day which will cover the peak of the test. Adex has a half-life of just less than 50 hrs.

Re your spike in T. It's normal. That's what happens after an injection. The below graph will help to show you that. Testing close to the day of injection is a great learning tool!

[mazguy]

The estradiol sensitive 8-35 range is the correct test. 20 is a great level for most guys.
Yes, I'd take the adex the same day which will cover the peak of the test. Adex has a half-life of just less than 50 hrs.

Re your spike in T. It's normal. That's what happens after an injection. The below graph will help to show you that. Testing close to the day of injection is a great learning tool!

Thanks again!