Printable View
After I change 4 endo private doctors with the cost of 200euro(50 per doctor) and 2 Federal ones, I finally found the doctor which he prescribe me both Nebido and Arimidex( she's a professor of Andrology) and she told me to do 1 ampule of Nebido every 6 weeks and 0.25mg arimidex every 2 days, I'm I wanna know your opinion guys, thank you.
Attachment 165881
You mean a booster at six weeks or that's the final protocol? It sounds way too much. AI is not usually needed on nebido but it might be appropriate given your situation.
50 euros for a private doc is dirty cheap comparing to western Europe. How much do you have to pay for nebido?
Nothing for Nebido and Arimidex, my insurance is covering them fully, She said first injection tomorrow and after six weeks for a load- after that every 10-12 weeksQuote:
Originally Posted by bizzarro
For the Arimidex I pressure her to prescribe me cause of the high E2 and she said take it and we will do blood test again next month to see how is going, she said 0.25mg eod will be enough.Quote:
Originally Posted by bizzarro
Doubtful you'll end up needing that much adex. .25 eod is the normal amount used for a cycle of 500 mgs test.Quote:
Originally Posted by TjmAble
Isn't a full ampoule of Nebido 1000 mg?
Interesting....
Yes, 1 ampule 1000mg in a 4ml Vial, she said 1injection now and one after 6 weeks because the previous corticosteroids I used and the recent situation as a CDK patient I should load up first and then I will continue to do 1 ampule per 10-12 weeks.Quote:
Originally Posted by Couchlockd
I was having elevated E2 if you have seen my previous post, normal range 40 and below and I was having 84 that was the purpose if AI I think but If its not that necessary I don't have to take it I believe.Quote:
Originally Posted by kelkel
So 1000 mg test every 3 months?
In not familiar with undecanate but that seems not quite right?
Like Wouldn't you crash after a 12 to 14 day period?
Undeconate says its half life is 12 days
Indeed and also your photo speak for itself but still it might be a tad too much, especially late in the interval. Difficult to predict how you will react to nebido.Quote:
Originally Posted by TjmAble
I've been telling you guys, we need andrology experts, the other endos only care about diabetes.Quote:
Originally Posted by TjmAble
I have to buy one of those this week.
Well I think she's going with the Nebido instructions which is saying 1 per 10 weeks and yes I think the estimated half life of Nebido is around 12-15 days, maybe a Vet can enlightened us...Quote:
Originally Posted by Couchlockd
True that buddy, and if you have noticed all the Endos have the "Special Title" next to their profession as Diabetes Expert.Quote:
Originally Posted by Mr.BB
She said to take it for a month so my estrogen can decrease a bit not fir the whole treatment and after the blood work if the estrogens are at normal levels she said I will not take arimidex again, the purpose is not to take it for the whole lifetime of the TRT.Quote:
Originally Posted by bizzarro
Quote:
Originally Posted by Couchlockd
This has been discussed a lot in some threads, there was never a consensus, above I've put Bayers information. Some conclusions were more in the region of 40-60 days.Quote:
Pharmacokinetic properties
Absorption
Nebido is an intramuscularly administered depot preparation of testosterone undecanoate and thus circumvents the first-pass effect. Following intramuscular injection of testosterone undecanoate as an oily solution, the compound is gradually released from the depot and is almost completely cleaved by serum esterases into testosterone and undecanoic acid. An increase in serum levels of testosterone above basal values may be seen one day after administration.
Steady-state conditions
After the 1st intramuscular injection of 1000 mg testosterone undecanoate to hypogonadal men, mean Cmax values of 38 nmol/L (11 ng/mL) were obtained after 7 days. The second dose was administered 6 weeks after the 1st injection and maximum testosterone concentrations of about 50 nmol/L (15 ng/mL) were reached. A constant dosing interval of 10 weeks was maintained during the following 3 administrations and steady-state conditions were achieved between the 3rd and the 5th administration. Mean Cmax and Cmin values of testosterone at steady-state were about 37 (11 ng/mL) and 16 nmol/L (5 ng/mL), respectively. The median intra- and inter-individual variability (coefficient of variation, %) of Cmin values was 22 % (range: 9-28%) and 34% (range: 25-48%), respectively.
Distribution
In serum of men, about 98% of the circulating testosterone is bound to sex hormone binding globulin (SHBG) and albumin. Only the free fraction of testosterone is considered as biologically active. Following intravenous infusion of testosterone to elderly men, the elimination half-life of testosterone was approximately one hour and an apparent volume of distribution of about 1.0 l/kg was determined.
Biotransformation
Testosterone which is generated by ester cleavage from testosterone undecanoate is metabolised and excreted the same way as endogenous testosterone. The undecanoic acid is metabolised by ß-oxidation in the same way as other aliphatic carboxylic acids. The major active metabolites of testosterone are oestradiol and dihydrotestosterone.
Elimination
Testosterone undergoes extensive hepatic and extrahepatic metabolism. After the administration of radio-labelled testosterone, about 90% of the radioactivity appears in the urine as glucuronic and sulphuric acid conjugates and 6% appears in the faeces after undergoing enterohepatic circulation. Urinary medicinal products include androsterone and etiocholanolone. Following intramuscular administration of this depot formulation the release rate is characterised by a half life of 90±40 days.
I'm taking arimdex at 1mg a week split over two doses. ..the more fat you lose, the less I believe you need as aromatase enzymes are located in fat.
Now that I'm reading your thread, I might cut back on the dosage I'm taking, I feel like I'm bottomed out on e2.
Initially 1mg was fine for me, I'd start low, and build up. But your endo seems great, maybe just follow her protocol for the time being and let her drive your recovery. You don't want to push her the wrong way, you can always adjust with your next blood work. Most importantly, you found a good doc. Congrats