Originally Posted by
Youthful55guy
Hi SHBG will push Total T up because it protects T from liver metabolism. However, the T is not bioavailable, so it does not pass through the blood brain barrier where you need it to feel normal and for normal libido. I suspect this may be your problem. About 10% of guys are genetically programmed for high SHBG (myself included). We add an extra sugar molecule to the SHBG protein and that more than doubles the half life of the protein. So, even though we produce SHBG at the "normal' rate, we effectively have more than twice the circulating amount of the protein because it is metabolized slower then the other 90% of men.
As we age, the rate of SHBG production increases for all of us, but for those of us with this genetic anomaly, it has a much greater effect. When we are young, the total amount of T we produce is enough to saturate the protein and enough spills over into free T to feel normal and to have normal libido, erections, and ejaculations. However, as we age and the SHBG goes way up, we can no longer saturate the protein and Free T falls below a critical amount. That's when we start to notice it.
For me there were slight indications at age 30. By age 40, definite indications (but still not as bad as you), by 50, my libido, erections. and ejaculations were in the dumpster and I was feeling depressed, even though I knew deep down that it wasn't clinical depression. I went through a series of doc that were more than willing to hand out antidepressants like candy (I turned them all down) before I came across one that accurately diagnosed my condition. I got the help I needed and the rest is history.