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Thread: Luteinizing hormone

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    pfdept59's Avatar
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    Luteinizing hormone

    After 6 months of TRT my LH has gone from 2.71 ml/U/ml to <o.2 L.Should I be concerned.I started out on 100 mg per week of Test Cyp. Then after 3 months doctor added anestrozole because my estrogen levels were high.Thanks for any advise

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    Youthful55guy is offline Knowledgeable Member
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    Quote Originally Posted by pfdept59 View Post
    After 6 months of TRT my LH has gone from 2.71 ml/U/ml to <o.2 L.Should I be concerned.I started out on 100 mg per week of Test Cyp. Then after 3 months doctor added anestrozole because my estrogen levels were high.Thanks for any advise
    No need for concern. Exogenous T will suppress natural LH (and FSH) secretion. The numbers should show less than detectable amounts.

    I am surprised your E is out of range on 100mg/week. What is your injection frequency? Breaking the dose up into two smaller 50mg doses twice a week (or better yet 44mg E3d) should prevent T levels peeking out of range, which is what drives E out of range (E is made from T). Anastrozole is very difficult to dose for guys without crushing your E levels and that can make things much worse than they were before TRT (particularly libido and ED). Guys need E too and many experts are proposing that moderately high E is not a problem for guys unless they are also playing with certain synthetic steroids for which E control is absolutely necessary (e.g., Nandrolone ).

    What is your injection protocol and what was your E level (with normal ranges)?
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    First 3 months 100 mg per week,next 3 months doc added anastrozole ,now I plan on splitting up my injections every 3.5 days and adding in HCG .What do you think.I feel great and have seen great progress in my training

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    I will post my blood work when I figure out how to.I had it at 3 months and 6 months.Maybe you could look it over for me.Thanks,pfdept59

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    Youthful55guy is offline Knowledgeable Member
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    Quote Originally Posted by pfdept59 View Post
    I will post my blood work when I figure out how to.I had it at 3 months and 6 months.Maybe you could look it over for me.Thanks,pfdept59
    How much anastrozole and what dosing schedule? It will be interesting to see you E levels pre and post anastrozole. I find the drug extremely difficult to dose without crashing E levels. I've stopped using it and have gone only with DIM supplement. Will have labs in a couple weeks on the DIM only protocol, so nothing I can report on effectives now.

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    Started with 1 mg tab per week,split in half on Monday and half on Thursday.3 months and it did nothing,doc is increasing it for the next 3 months to 2 mg per week

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    Youthful55guy is offline Knowledgeable Member
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    Quote Originally Posted by pfdept59 View Post
    Started with 1 mg tab per week,split in half on Monday and half on Thursday.3 months and it did nothing,doc is increasing it for the next 3 months to 2 mg per week
    1mg is a very large dose for a guy on just 100 mg of T per week. 2mg is HUGE. Can you post your E2 labs? I'm really questioning your doc's wisdom in this matter.

    By comparison, I just finished an experimental run of 200mg T per week (I have very high SHBG) and I was using 0.5mg anastrozole per week (eye dropper daily dosing method) and it crushed my E2 to 12.1 pg/L (range 8-35). I have since lowered my T dose to 180 (TT and FT were way too high) and completely eliminated the anastrozole. I just added DIM. Next labs are scheduled in another 4 weeks and more than likely I will scale back the T dose to 160mg and keep lowering the dose until FT comes back into range. I'm working out the details of a alternative to lowering SHBG with low dose synthetic anabolic steroids (e.g., Winstrol or Anavar or Danazol).

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    my estriol level was 42 pg/mL on March 1 it went up to 56 pg/mL on June 5 while I was taking the 1 mg per week of anastrozole.I think that is why the doc is increasing my dose of Test C and anastrozole

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    Youthful55guy is offline Knowledgeable Member
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    Quote Originally Posted by pfdept59 View Post
    my estriol level was 42 pg/mL on March 1 it went up to 56 pg/mL on June 5 while I was taking the 1 mg per week of anastrozole.I think that is why the doc is increasing my dose of Test C and anastrozole
    I'm amazed that 1mg per week did not work for you. It kills my E2 level. I would not be hugely concerned with 56 pg/mL unless you are using other synthetic steroids with your T, but it's getting to the range where I would do something too. There's conflicting thoughts among the experts on how high a guy's E2 can go. I've personally set my limit at 50 pg/mL using the LabCorp Sensitive assay.

    Labs don't lie, so in your case, perhaps 2mg might be the right dose for you. However, close monitoring with periodic labs is advised.

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    Doc said lowering my estrogen levels will free up more free testosterone from my total test level.I feel great since starting TRT and have made good progress in the gym

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    Windex is online now Staff ~ HRT Optimization Specialist
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    You shouldn't be needing an AI on 100mg of Test. You'd be more likely to get struck by lightning or win the lottery to be 100% honest.

    I would be injecting E3D or 3x per week not every 3.5 days.

    Depending on bloodwork, DIM should be utilized before any drugs.

    Vitamin D3 should be part of your HRT protocol. I would argue DHEA should be as well.
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    Youthful55guy is offline Knowledgeable Member
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    Quote Originally Posted by Windex View Post
    You shouldn't be needing an AI on 100mg of Test. You'd be more likely to get struck by lightning or win the lottery to be 100% honest.

    I would be injecting E3D or 3x per week not every 3.5 days.

    Depending on bloodwork, DIM should be utilized before any drugs.

    Vitamin D3 should be part of your HRT protocol. I would argue DHEA should be as well.
    While I agree with your advice, I'm just amazed that at 100mg/week while taking 1mg of anastrozole that his E2 levels increased rather than decreased (assuming that it was split into at least 2 X 0.5mg anastrozole). That much anastrozole crushes my E2 at even higher doses of T. Regardless, labs don't lie. I'm beginning to wonder of the quality of the anastrozole he's getting.

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