To all those on HCG Monotherapy, is it necessary to supplement with Pregnenolone, as it is standard procedure on most TRT and TRT+HCG protocols. I take anywhere from 250-500IU ED. I never exceed 3500IU/week, and never go below 2000IU/wk. I take .15mg Arimidex ED. I know Dr. John Crisler often gives his patients Preg cream for those on his TRT + 500IU/wk patients, as a safeguard against low PREG, but I am on HCG Monotherapy, and thus am enducing far more 450cc enzyme pathway stimulation CHOL->PREG, and feel that it is overkill, and will likely overstimulate the 450cc pathway.