TRT and Diabetes!

**bass** · 09-08-2011, 01:58 PM

well, in the past couple of days and for the first time i noticed my glucose level above 100, more like 118-124, and i did the test in the morning fasting. so i had my family doc order a Diabetes test and will do it tomorrow. Diabetes runs in the family so i am not asking if TRT had anything to do with it, but my questions is, if i have Diabetes, how is this going to effect me being on TRT?

PS. i Hadley eat sweets or simple sugars, most of my sugar consumption is from fruits and grain, but mostly fruits and veggies!

**zaggahamma** · 09-08-2011, 03:57 PM

dont see how it would relate...separate issue...OR...get some slin???????? lol/jk

sorry to hear bro

i'm going to follow this as i've had tests hover around a hundred a few fasting tests..

can u check after a meal and post up the reading

**steroid.com 1** · 09-08-2011, 04:12 PM

Yea, sorry to hear bass; lets see how your test results come back. Diabetes and TRT protocols can be co-administered; my Doc provides care for a number of Diabetic patients with great success...so relax a bit.

Funny, I found this research summary below just this morning. Also, there are other studies that found that TRT protocols are associated with beneficial effects on insulin resistance, total and LDL-cholesterol, Lpa, and sexual health in hypogonadal men with type 2 diabetes and/or MetS.

Update: hypogonadotropic hypogonadism in type 2 diabetes and obesity.

J Clin Endocrinol Metab. 2011 Sep;96(9):2643-51

Authors: Dandona P, Dhindsa S

Abstract
Studies over the last few years have clearly established that at least 25% of men with type 2 diabetes have subnormal free testosterone concentrations in association with inappropriately low LH and FSH concentrations. Another 4% have subnormal testosterone concentrations with elevated LH and FSH concentrations. The Endocrine Society, therefore, now recommends the measurement of testosterone in patients with type 2 diabetes on a routine basis. The subnormal testosterone concentrations are not related to glycosylated hemoglobin or duration of diabetes, but are associated with obesity, very high C-reactive protein concentrations, and mild anemia. In addition, subnormal testosterone concentrations in these men are associated with a two to three times elevated risk of cardiovascular events and death in two early studies. Short-term studies of testosterone therapy in hypogonadal men with type 2 diabetes have demonstrated an increase in insulin sensitivity and a decrease in waist circumference. However, the data on the effect of testosterone replacement on glycemic control and cardiovascular risk factors such as cholesterol and C-reactive protein concentrations are inconsistent. As far as sexual function is concerned, testosterone treatment increases libido but does not improve erectile dysfunction and thus, phosphodiesterase inhibitors may be required. Trials of a longer duration are clearly required to definitively establish the benefits and risks of testosterone replacement in patients with type 2 diabetes and low testosterone .

PMID: 21896895 [PubMed - in process]

**Bigfoot66** · 09-08-2011, 04:19 PM

My fasting test was 118 as well. Had to do that test that assesses levels over 3 months. Came back one point below the diabetes level. He attributed to insulin sensitivity as it relates to TRT protocol. You may want to read up on it. My intake of sugar is about same as yours.

Originally Posted by gdevine

Yea, sorry to hear bass; lets see how your test results come back. Diabetes and TRT protocols can be co-administered; my Doc provides care for a number of Diabetic patients with great success...so relax a bit.

Funny, I found this research summary below just this morning, good read:

Update: hypogonadotropic hypogonadism in type 2 diabetes and obesity.

J Clin Endocrinol Metab. 2011 Sep;96(9):2643-51

Authors: Dandona P, Dhindsa S

Abstract
Studies over the last few years have clearly established that at least 25% of men with type 2 diabetes have subnormal free testosterone concentrations in association with inappropriately low LH and FSH concentrations. Another 4% have subnormal testosterone concentrations with elevated LH and FSH concentrations. The Endocrine Society, therefore, now recommends the measurement of testosterone in patients with type 2 diabetes on a routine basis. The subnormal testosterone concentrations are not related to glycosylated hemoglobin or duration of diabetes, but are associated with obesity, very high C-reactive protein concentrations, and mild anemia. In addition, subnormal testosterone concentrations in these men are associated with a two to three times elevated risk of cardiovascular events and death in two early studies. Short-term studies of testosterone therapy in hypogonadal men with type 2 diabetes have demonstrated an increase in insulin sensitivity and a decrease in waist circumference. However, the data on the effect of testosterone replacement on glycemic control and cardiovascular risk factors such as cholesterol and C-reactive protein concentrations are inconsistent. As far as sexual function is concerned, testosterone treatment increases libido but does not improve erectile dysfunction and thus, phosphodiesterase inhibitors may be required. Trials of a longer duration are clearly required to definitively establish the benefits and risks of testosterone replacement in patients with type 2 diabetes and low testosterone .

PMID: 21896895 [PubMed - in process]

**bass** · 09-08-2011, 04:51 PM

good info guys, Thanks! and yes JP I'll post my levels after i eat!

**gixxerboy1** · 09-08-2011, 06:27 PM

im a diabetic and on trt. it should have no effect

**bass** · 09-08-2011, 08:45 PM

okay, something is screwy here! two hours after i ate linguine with clams and white sauce with tons of butter!

!!!.... i checked my glucose level, poked my pinkie and did the test twice, first it read 108 and the second 109! so very consistent, right? then immediately after i poked my index finger and did the test, it read 148! WTF? are my test sticks bad, or my meter is fvcked up? BTW, i do squeeze couple of drops off then do the test with the third squeeze!

**zaggahamma** · 09-08-2011, 09:04 PM

thats another good question....meters go bad QUICK....I forgot that i had a 200 reading on one meter and normal on another

**gixxerboy1** · 09-09-2011, 08:15 AM

there is no reason to squeeze off blood first. Use the first drops that come out.
is your meter coded correctly?
I would use the control solution and test the strips.

**zaggahamma** · 09-09-2011, 08:19 AM

Originally Posted by gixxerboy1

there is no reason to squeeze off blood first. Use the first drops that come out.
is your meter coded correctly?
I would use the control solution and test the strips.

this douchebag at the blood donation center did that shit like 4 times...i was like ...wtf...one of those places that think everything needs an overhaul...changing the way you check in, blah blah blah...but yes, agree the meter might not be accurate....how can you get it coded? do they just expire?

**Fred40** · 09-09-2011, 12:43 PM

Just F.Y.I.

Testosterone replacement therapy improves survival in diabetic men with low testosterone levels

April - 29 - 2011

Two studies examining the effects of low testosterone in diabetic men indicate that low testosterone is associated with poor health-related quality of life (HRQoL) and that testosterone replacement therapy (TRT) can improve survival. The first study analyzed total testosterone (TT), bioavailable testosterone (BT) and sex hormone-binding globulin (SHBG) levels in morning blood samples from 356 men with diabetes (mean age 58.5 years), 126 of whom also completed an International Index of Erectile Function Score (IIEF) questionnaire. TT levels significantly correlated with HRQoL (r = 0.353, P < 0.04) when corrected for SHBG. IIEF scores significantly correlated with TT (r = 0.546, P < 0.001), BT (r = 0.506, P < 0.004) and free testosterone (r = 0.532, P < 0.001). In the second study, 578 men with diabetes (mean age 61 years) who had TT performed between 2002 and 2005 and were followed up for 5.8 years, were analyzed in three groups: i) normal TT (> 10.4 nmol/L; n = 338), ii) low TT (< 10.4 nmol/L) without TRT (n = 182) and iii) low TT with TRT (n = 58). Survival was significantly improved in patients with low testosterone who underwent TRT (P = 0.049 log rank) (Brooke, J. et al. Endocr Abstr [Soc Endocrinol BES 2011 (April 11-14, Birmingham) 2011] 2011, 25: Abst P152; Muraleedharan, V. et al. Endocr Abstr [Soc Endocrinol BES 2011 (April 11-14, Birmingham) 2011] 2011, 25: Abst P163).

**gixxerboy1** · 09-09-2011, 01:47 PM

Originally Posted by jpkman

this douchebag at the blood donation center did that shit like 4 times...i was like ...wtf...one of those places that think everything needs an overhaul...changing the way you check in, blah blah blah...but yes, agree the meter might not be accurate....how can you get it coded? do they just expire?

most strips have a number code on them. The machine has to be set to the same number to be accurate. Some machines take a little chip that comes with the vial of strips. Other machines its just changing the code number by using the buttons,

also there is a control solution you can use to test the machine and strips. You put it on instead of blood and it should come out in a certain range

**zaggahamma** · 09-09-2011, 02:51 PM

Originally Posted by gixxerboy1

most strips have a number code on them. The machine has to be set to the same number to be accurate. Some machines take a little chip that comes with the vial of strips. Other machines its just changing the code number by using the buttons,

also there is a control solution you can use to test the machine and strips. You put it on instead of blood and it should come out in a certain range

so only when the machine wont code/calibrate is when you toss it? i forgot there were test test strips

**gixxerboy1** · 09-09-2011, 03:26 PM

Originally Posted by jpkman

so only when the machine wont code/calibrate is when you toss it? i forgot there were test test strips

no you code it every time you get a new vial of strips. The vial should have a number on them. Like code 17. Some machines you just press buttons on the machine to match it to code 17. Some machines take a little chip for the code. Each vial of strips should come with a chip to put into the machine.

the only time a machine is no go is when you use the control solution on the strip and it doesnt come in range. I have never had a machine go bad in 25 years

**bass** · 09-14-2011, 12:49 PM

well, i don't have Diabetes! however i am at risk of becoming diabetic, my glucose was at 100 range is 65-99. here is the interesting part though, my doc also checked for Hemoglobin Alc, my level was 5.2 range is 4.8-5.6. is this the same hemoglobin we try to control through donating blood? if so then the raised hemoglobin could play a big part in leading you to become diabetic! no? if not why would he check for Hemoglobin?