Nebido Transition Protocol

[Youthful55guy]

I had a little time on my hands and started playing some "what if" scenarios of transitioning to a 50/50 blend of T-Undecanoate (Nebido 250 mg/mL) and T-Cyp (200 mg/mL). I was shooting for an average release of about 11 mg of molecular T per day because this is close to my prescribed dose and from personal experience where I feel my best when I control SHBG to mid-range.

So here's the graph of what it would look like to start from ground zero with 0.22 mL of a 50/50 Blend E3D. It takes about 3 months to get to a stable release profile, but once stable, it averages about 10.9 mg T released per day and varies within a very narrow window of 9.7 to 11.5 mg/day. pretty good!


The first 4 weeks looked a little brutal until you reached effective levels, so I started playing with various transition doses of supplemental T-cyp to make the ride a little smoother. Here's a graph of what I think is an optimal transition protocol of 0.1 mL supplemental T-cyp (20mg) E3D during weeks 1-2, then 0.05 mL supplemental T-cyp E3D (10 mg) during weeks 3-5. This transition protocol brings blood levels of T up fairly rapidly over the first 2 weeks and then stabilizes them to near optimal levels (just a tad higher).


I have no current plans to try this protocol, but it does intrigue me. Perhaps someday. Comments welcome!

[Amuuzen]

Interested to know where the software that runs the algorithm for the blood levels comes from? Does it account for just a healthy person or take other variables (like other meds or compromised metabolic issues) into account?

[Youthful55guy]

http://steroidcalc.com/

It uses half life equations and estimated published half life data. Like everything biological, averages never account for variability. More than likely, the longer the half life, the greater the variability.

The system plots out molecular T released per day, which I've always argued is more important than actual dosage because the ester potion of the molecule varies from compound to compound and must be taken into account. For example T-prop is about 84% T, T-cyp is 68% T and T-Und is 61% T.

Most published studies of half life data only use healthy adults. There's no way to account for health state of the individual for any medication. This is why dose ranges exist.

there is a link you can press on the web page that will take you to another page with more in depth explanations of the calculation methods.

The software is only intended to guide decision making, and it's actually not intended for medical treatment with TRT. It's an anabolic steroid cycle planner that I've adapted for TRT purposes. It's the best that I've been able to find anywhere and helps with dosing decisions.

[almostgone]

I had a little time on my hands and started playing some "what if" scenarios of transitioning to a 50/50 blend of T-Undecanoate (Nebido 250 mg/mL) and T-Cyp (200 mg/mL). I was shooting for an average release of about 11 mg of molecular T per day because this is close to my prescribed dose and from personal experience where I feel my best when I control SHBG to mid-range.

So here's the graph of what it would look like to start from ground zero with 0.22 mL of a 50/50 Blend E3D. It takes about 3 months to get to a stable release profile, but once stable, it averages about 10.9 mg T released per day and varies within a very narrow window of 9.7 to 11.5 mg/day. pretty good!


The first 4 weeks looked a little brutal until you reached effective levels, so I started playing with various transition doses of supplemental T-cyp to make the ride a little smoother. Here's a graph of what I think is an optimal transition protocol of 0.1 mL supplemental T-cyp (20mg) E3D during weeks 1-2, then 0.05 mL supplemental T-cyp E3D (10 mg) during weeks 3-5. This transition protocol brings blood levels of T up fairly rapidly over the first 2 weeks and then stabilizes them to near optimal levels (just a tad higher).


I have no current plans to try this protocol, but it does intrigue me. Perhaps someday. Comments welcome!

Interesting. My Dr. had mentioned Aveed, but I was sketchy on how bad the troughs would be w/ the 750mg/3cc dosage and 10 week 3cc doses, plus I would have to go into the office for the test undecanoate injections. I like how you smoothed out the transition because that had me worried as well.

[hammerheart]

I plan to do this, but I'll be using Test Decanoate as a bridge of sorts, to see if I do well with an ester longer than enanthate first. Had a quite bad experience with nebido before but I was doing regular protocol, if going with TU again I'd be pinning a lower dose once weekly.

[Mr.BB]

You can't use that calculator for nebido. There is the effect nebido creating a 4ml ball

[Youthful55guy]

730mg every 10 weeks seems like a brutal protocol! Unfortunately, the longest the software allows is every 8 weeks between injections. Here's what 750mg of Tu would look like every 8 weeks. Every 10 weeks would be even worse!

[Youthful55guy]

I plan to do this, but I'll be using Test Decanoate as a bridge of sorts, to see if I do well with an ester longer than enanthate first. Had a quite bad experience with nebido before but I was doing regular protocol, if going with TU again I'd be pinning a lower dose once weekly.

I haven't worked out a weekly protocol yet. That was my original plan and then somehow I got started on E3D dosing (my current protocol with T-cyp). I am intrigued with a longer ester and weekly injections if I can get levels as stable as my current protocol of 40-50 mg T-cyp E3D. I'll post a protocol if I ever get one worked out.

[Youthful55guy]

You can't use that calculator for nebido. There is the effect nebido creating a 4ml ball

Like any protocol, it must be followed up with labs and adjustments made. it gives you a place to start. However, I disagree and would argue the opposite. The half life equations would be closer to the theoretical release curves when one uses smaller doses than large bolus doses. With smaller doses, there is no TU pocket (ball) effect.

[kelkel]

You are officially hooked on that site and those graphs!

[Youthful55guy]

You are officially hooked on that site and those graphs!

Guilty!

[Mr.BB]

Like any protocol, it must be followed up with labs and adjustments made. it gives you a place to start. However, I disagree and would argue the opposite. The half life equations would be closer to the theoretical release curves when one uses smaller doses than large bolus doses. With smaller doses, there is no TU pocket (ball) effect.

Sorry, can understand your sentences, maybe im too dumb.