
Originally Posted by
einstein1905
Well, here's the argument against using them together:
Insulin decreases the proteolytic events that degrade IGFBPs, so the result is a greater concentration of IGFBPs, which will reduce the activity of the IGF-1 expressed in response to GH. However, as with everything, this is not black and white. An increase in IGFBPs means what? What magnitude of an increase? 5%? 10%? more?
I use the two together, but I also use LR3 when I'm using Humalog too, so increased IGFBPs means nothing to me.
GH and insulin do complement each other, and the minor increase in IGFBPs (if significant at all) isn't enough to outweigh the benefits of using the two together IMO.