Here's an interesting article I came across that suggests that lowering IGF levels may actually prolong life, at least in mice.
http://www.washingtonpost.com/wp-dyn...501224_pf.html
Here's the interesting part: "Studies, for example, suggest that damping down this pathway -- known as the insulin/insulin-like growth factor-1 signaling pathway -- may be the mechanism that extends longevity in animals that are fed an ultra-low-calorie diet."
Here I assume that by damping the pathway, they mean reducing IGF levels.
Here's the abstract of another study that shows that reduced IGF is associated with delayed aging:
http://www.ingentaconnect.com/conten...00001/05107891
This seems counterintuitive given how popular HGH is in anti-aging treatments, but its use in this context is relatively new and there's probably a lot we don't know yet about the long term effects.