Warning about IGF-lr3! Take with grain of salt

**Duct Tape** · 10-13-2005, 11:04 AM

Found this e-mail posted over at 'Bolex........hmmmmm

From GroPep:

No-one who knowingly supplies IGF-I for human use would be an
authorised GroPep Distributor as this would be in breach of their contractual
agreement with us.

As Pat Wallace mentioned to you previously, LONG[TM]R[3]IGF-I is a
GroPep patented product manufactured exclusively by GroPep for use in Cell
Culture. Like all GroPep products, it is NOT for use in humans or
animals. This product is only available to our registered cell culture
distributors, so no genuine product will be available elsewhere.

You may also be interested in the following information. To put it
simply, no-one in their right mind would use LONG[TM]R[3]IGF-I in a human.
LONG[TM]R[3]IGF-I is a different molecule to IGF-I, having a modified
amino acid sequence. This gives LONG[TM]R[3]IGF-I a dramatically
different shape and different biological characteristics to IGF-I. What this
means is that results obtained with IGF-I may not apply to
LONG[TM]R[3]IGF-I. LONG[TM]R[3]IGF-I was specifically formulated for use in
Industrial Cell Culture on individual cells. In this application it works
brilliantly, being more potent than IGF-I. However isolated cells are
not the same as an intact animal as, for example, they do not have
kidneys or an immune system. As a result, LONG[TM]R[3]IGF-I should NEVER
under ANY circumstances be used in humans as it may prove fatal. This has
nothing to do with purity, rather it is the LONG[TM]R[3]IGF-I molecule
itself that is the potential problem. Illicit use is therefore a
safety issue. Anything anyone tells you to the contrary is rubbish,
irrespective of what evidence or experience they CLAIM to have.

The mistaken belief that IGF-I and particularly LONG[TM]R[3]IGF-I are
useful as performance enhancing agents has resulted in a high demand for
LONG[TM]R[3]IGF-I and a thriving trade in counterfeit products or
GroPep vials, vials that do not contain what is claimed on the label.

There is presently no scientific publication that shows selective
muscle build up following IGF-I administration in any species other than the
rat. In fact, due to various complications and side effects, systemic
administration of IGF-I has often been found in clinical trials to
decrease rather than increase lean muscle mass. So from a muscle building
point of view IGF-I doesn't work. Even the more reputable Body
Building magazines say so.

For your further information here are a few points to remember:

1. GroPep developed and holds the world wide Patents on
LONG[TM]R[3]IGF-I and we are the only manufacturer. We will prosecute those who
infringe our Patent rights.

2. More IGF is supposedly available in any gym, on any street in any
city at any time than all the world's manufacturers of IGF could make in
10 years working round the clock. What is on offer therefore, cannot
possibly be IGF-I.

3. Making IGFs is very difficult. It is not something that a
back-yard lab could do.

4. IGF-I administration has only been shown to increase lean muscle
mass in rats, not in humans.

5. To the best of my knowledge, all the clinical trials that have been
undertaken using systemic IGF-I for building muscle mass have either
been terminated prematurely due to adverse reactions or have not proven
effective.

6. We know there is a culture or belief in the body building community
that GroPep products are easy to obtain. I can assure you that GENUINE
GroPep products are not.

7. We also know there is a thriving trade in fake GroPep vials, vials
that do not contain what is claimed on the label. What is in these
vials is anybody's guess but it is not IGF-I. To therefore use them would
be the chemical equivilant of Russian Roulette.

8. We have never found IGF-I or LONG[TM]R[3]IGF-I in any vial we have
been given to analyse, irrespective of what it may say on the label.

9. Our shipments do NOT go missing.

Kindest regards,

Dr. Stephen Hardy
Biotechnology Reagents Marketing Manager.

**Logan13** · 10-13-2005, 11:20 AM

Originally Posted by Duct Tape

Found this e-mail posted over at 'Bolex........hmmmmm

From GroPep:

No-one who knowingly supplies IGF-I for human use would be an
authorised GroPep Distributor as this would be in breach of their contractual
agreement with us.

As Pat Wallace mentioned to you previously, LONG[TM]R[3]IGF-I is a
GroPep patented product manufactured exclusively by GroPep for use in Cell
Culture. Like all GroPep products, it is NOT for use in humans or
animals. This product is only available to our registered cell culture
distributors, so no genuine product will be available elsewhere.

You may also be interested in the following information. To put it
simply, no-one in their right mind would use LONG[TM]R[3]IGF-I in a human.
LONG[TM]R[3]IGF-I is a different molecule to IGF-I, having a modified
amino acid sequence. This gives LONG[TM]R[3]IGF-I a dramatically
different shape and different biological characteristics to IGF-I. What this
means is that results obtained with IGF-I may not apply to
LONG[TM]R[3]IGF-I. LONG[TM]R[3]IGF-I was specifically formulated for use in
Industrial Cell Culture on individual cells. In this application it works
brilliantly, being more potent than IGF-I. However isolated cells are
not the same as an intact animal as, for example, they do not have
kidneys or an immune system. As a result, LONG[TM]R[3]IGF-I should NEVER
under ANY circumstances be used in humans as it may prove fatal. This has
nothing to do with purity, rather it is the LONG[TM]R[3]IGF-I molecule
itself that is the potential problem. Illicit use is therefore a
safety issue. Anything anyone tells you to the contrary is rubbish,
irrespective of what evidence or experience they CLAIM to have.

The mistaken belief that IGF-I and particularly LONG[TM]R[3]IGF-I are
useful as performance enhancing agents has resulted in a high demand for
LONG[TM]R[3]IGF-I and a thriving trade in counterfeit products or
GroPep vials, vials that do not contain what is claimed on the label.

There is presently no scientific publication that shows selective
muscle build up following IGF-I administration in any species other than the
rat. In fact, due to various complications and side effects, systemic
administration of IGF-I has often been found in clinical trials to
decrease rather than increase lean muscle mass. So from a muscle building
point of view IGF-I doesn't work. Even the more reputable Body
Building magazines say so.

For your further information here are a few points to remember:

1. GroPep developed and holds the world wide Patents on
LONG[TM]R[3]IGF-I and we are the only manufacturer. We will prosecute those who
infringe our Patent rights.

2. More IGF is supposedly available in any gym, on any street in any
city at any time than all the world's manufacturers of IGF could make in
10 years working round the clock. What is on offer therefore, cannot
possibly be IGF-I.

3. Making IGFs is very difficult. It is not something that a
back-yard lab could do.

4. IGF-I administration has only been shown to increase lean muscle
mass in rats, not in humans.

5. To the best of my knowledge, all the clinical trials that have been
undertaken using systemic IGF-I for building muscle mass have either
been terminated prematurely due to adverse reactions or have not proven
effective.

6. We know there is a culture or belief in the body building community
that GroPep products are easy to obtain. I can assure you that GENUINE
GroPep products are not.

7. We also know there is a thriving trade in fake GroPep vials, vials
that do not contain what is claimed on the label. What is in these
vials is anybody's guess but it is not IGF-I. To therefore use them would
be the chemical equivilant of Russian Roulette.

8. We have never found IGF-I or LONG[TM]R[3]IGF-I in any vial we have
been given to analyse, irrespective of what it may say on the label.

9. Our shipments do NOT go missing.

Kindest regards,

Dr. Stephen Hardy
Biotechnology Reagents Marketing Manager.

VERY INTERESTING. I guess that the great results that I have had in 2 cycles with IGF-Lr3 could be attributed to a psychosomatic response. How can real world use appear to be so different from what the lab/manufacturer states? I think that they may fear the red tape associated with IGF becoming a controlled substance.

-Logan13

**Duct Tape** · 10-13-2005, 11:35 AM

I think it is a little CYA going on.

***JohnnyB*** · 10-13-2005, 11:39 AM

#4 and 6 are questionable, 4 I've never seen any studies done on humans, but from what he's saying they have been done, I love to see them. #6, where did he get that info, you need a liecense to get, that's not easy. But where there's money to be made, their's always someone that wants to cash in and if they have the proper paper work, their in

JohnnyB

**oswaldosalcedo** · 10-13-2005, 11:42 AM

in studies head to head in animals,there is minimal differences to insulin ,and insulin is not the holy grail.
LR3 IS HYPERBOLE.

**oswaldosalcedo** · 10-13-2005, 11:47 AM

4 Is Not True,there Studies In Sheeps. (with Igf 1).
Point 6, You Can Buy it From Afsbio.(legally LR3 AND IGF 1, but expensive).

**majorpecs** · 10-13-2005, 11:54 AM

wow...so who exactly made the original post? A verified employee of GroPep?

**Pinnacle** · 10-13-2005, 12:02 PM

Originally Posted by Duct Tape

6. We know there is a culture or belief in the body building community
that GroPep products are easy to obtain. I can assure you that GENUINE
GroPep products are not.

So does this mean MR is lying about where thier product comes from?I know MR in the past has used gensci,but they since discontinued using it.

~Pinnacle~

**majorpecs** · 10-13-2005, 04:48 PM

Bump, my curiosity is piqued now.

**Seattle Junk** · 10-13-2005, 05:15 PM

I believe it's a legal motivated response to detract any responsibility if someone does become hurt from using it. That way if they were ever taken to court they can reference back on memos/releases like this. Hell yeah they know BBs use it. They're accepting the money to fill orders. If they are so concerned about humans using it, then why don't they do their due dilligence on their customers? Money is evil..... But I l believe r3IGF-1 is safe in a healthy adult. All prop BBs have used it since the early to mid 90's. That's 10 or so years of human self trial. Damn Gropep is making tons of money. Once it gets scheduled, the fun is over for them...It'll go UG and eventually become cheaper.

**kaorialfred** · 10-14-2005, 07:29 AM

so bump for more info
I know your not suppose to belive everything you read, but I mean this kinda discredits two well know suppliers of IGF. Have they responded to this? How can you check up on a supplier and know and compare the info here?

**groundandpoundpwr21** · 10-14-2005, 11:02 PM

I wonder what the two "O" suppliers think of this?

**inevitable** · 10-16-2005, 02:37 AM

i dunno... goprep is hating on other suppliers basically.

**jerseyboy** · 10-16-2005, 08:57 AM

I've seen this before. It was a reply someone got from GroPep after inquiring about purchasing IGF powder. Sounds like someone in the legal dept. at groPep with a good imagination and writing skills to boot.

**inevitable** · 10-16-2005, 01:28 PM

Originally Posted by jerseyboy

I've seen this before. It was a reply someone got from GroPep after inquiring about purchasing IGF powder. Sounds like someone in the legal dept. at groPep with a good imagination and writing skills to boot.

agreed