Ghrp-6

[dream warrior]

bro's how much do you take from this stuff?and how long can you take it is it weeks(like IGF)or months(like GH)?

[ss01]

Take it like hgh 5on/2off or EOD. I know one guy who uses 200mcg ED 5on/2off with great results. I usually run 100mcg ED.

[Carlito B]

GHRP-6 is like clomid to an AAS PCT
Hexarelin is like Hcg to an AAS PCT

best when used together and when your GH levels are suppressed, i'dlike to call it a GH cycle PCT.

C

[Carlito B]

Journal of Clinical Endocrinology & Metabolism, Vol 80, 942-947, Copyright © 1995 by Endocrine Society


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ARTICLES


Blocked growth hormone -releasing peptide (GHRP-6)-induced GH secretion and absence of the synergic action of GHRP-6 plus GH-releasing hormone in patients with hypothalamopituitary disconnection: evidence that GHRP- 6 main action is exerted at the hypothalamic level
V Popovic, S Damjanovic, D Micic, M Djurovic, C Dieguez and FF Casanueva
Institute of Endocrinology, University Clinical Center, Belgrade, Yugoslavia.

GH-releasing peptide (GHRP-6; His-D Trp-Ala-Trp-D Phe-Lys-NH2) is a synthetic compound that releases GH in a specific and dose-related manner through mechanisms and a point of action that are mostly unknown but different from those of GHRH. In man, GHRP-6 is more efficacious than GHRH, and a striking synergistic action on GH release is observed when GHRP-6 and GHRH are administered simultaneously. Based on such a synergistic action, it has been hypothesized that GHRP-6 acts through a double mechanism by actions exerted both at the pituitary and hypothalamic levels. The aim of the present study was 2-fold: 1) to further characterize the mechanism of action and synergistic effects of GHRP-6; and 2) to study its action in patients with hypothalamopituitary disconnection. Twelve patients with different neuroendocrine pathologies leading to a state of hypothalamopituitary disconnection (functional stalk section) and 11 age- and sex-matched normal controls were studied. Each subject underwent 3 tests on separate occasions, being challenged with GHRH (100 micrograms, i.v.), GHRP-6 (90 micrograms, i.v.), or GHRH plus GHRP-6. GH was analyzed as the area under the curve (mean +/- SE, micrograms per L/120 min). In normal subjects GH secretion was 483.7 +/- 99.2 after GHRH, 1434.8 +/- 393.0 after GHRP-6, and 3771.5 +/- 399.6 after GHRH plus GHRP-6; the level of GH secreted after GHRH plus GHRP-6 treatment was significantly (P < 0.05) higher than after the arithmetic sum of GH levels after both compounds administered separately. In the group of patients with hypothalamopituitary disconnection, the level of GH secreted after GHRH was similar to that in controls (423.4 +/- 62.8); however, a complete blockade was observed after GHRP-6 (97.3 +/- 7.9), significantly (P < 0.05) lower than after GHRH as well as lower than the GHRP-6-induced GH release in control subjects (P < 0.01). After GHRH plus GHRP-6, the patients with hypothalamopituitary disconnection showed severely reduced secretion (745.3 +/- 67.6; P < 0.01 vs. controls), a value that was not significantly different from the arithmetic addition of levels produced by both compounds administered separately.(ABSTRACT TRUNCATED AT 400 WORDS)

[Carlito B]

Journal of Clinical Endocrinology & Metabolism, Vol 78, 693-698, Copyright &#169; 1994 by Endocrine Society


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ARTICLES


Growth hormone -releasing activity of hexarelin, a new synthetic hexapeptide, after intravenous, subcutaneous, intranasal, and oral administration in man
E Ghigo, E Arvat, L Gianotti, BP Imbimbo, V Lenaerts, R Deghenghi and F Camanni
Department of Clinical Pathophysiology, University of Turin, Italy.


We evaluated the GH-releasing activity of hexarelin, a new synthetic hexapeptide, after i.v. (1 and 2 micrograms/kg), sc (1.5 and 3 micrograms/kg), intranasal (20 micrograms/kg), and oral (po; 20 and 40 mg) administration to 12 healthy young volunteers. Reference treatments were i.v. saline and GH-releasing hormone (GHRH; 1 microgram/kg). GH release (mean +/- SEM) after the i.v. dose of 1 microgram/kg hexarelin [area under the curve (AUC), 3175 +/- 506 micrograms/min.L] was about 2 times higher than that induced by 1 microgram/kg GHRH (AUC, 1544 +/- 161 micrograms/min.L; P < 0.001). Hexarelin (2 micrograms/kg, i.v.) elicited a further increase in GH levels (AUC, 4422 +/- 626 micrograms/min.L) compared to the 1 microgram/kg dose. The GH response to 2 micrograms/kg hexarelin, i.v., was very reproducible (AUC, 4016 +/- 563 vs. 3959 +/- 803 micrograms/min.L). The sc administration of hexarelin produced a dose-dependent GH response (AUC, 3180 +/- 392 and 4459 +/- 566 micrograms.min.L with 1.5 and 3 micrograms/kg, respectively). Intranasal administration of 20 micrograms/kg hexarelin induced GH release (AUC, 2642 +/- 452 micrograms/min.L) similar to that caused by 1 microgram/kg, i.v. Twenty and 40 mg hexarelin, po, produced a dose-related increase in GH levels (AUC, 2278 +/- 442 and 4079 +/- 514 micrograms/min.L). Biological bioavailabilities were 77.0 +/- 10.5%, 4.8 +/- 0.9%, and 0.3 +/- 0.1% for the sc, intranasal, and po routes, respectively. This study shows that the GH response to hexarelin administered by the i.v. route has a limited variability and is superior to the response to GHRH. The GH-releasing activity appeared to be dose dependent. Thus, hexarelin could be clinically useful to stimulate GH secretion in humans.

[dream warrior]

Take it like hgh 5on/2off or EOD. I know one guy who uses 200mcg ED 5on/2off with great results. I usually run 100mcg ED.

do you take this in 2x50mcg or just 1x100mcg?and around workout maybe pre or post?

[ss01]

do you take this in 2x50mcg or just 1x100mcg?and around workout maybe pre or post?

2x50 is what I do. Morning and late afternoon. This is scheduled around natural production of hGH rather than workout. This is injectable. There is an oral, time-released version which is taken once a day and released over 48 hours.

[dream warrior]

mine will be injectable to,how long do you run it bro?do you have to run it at least 12 weeks like normal GH?
thanx for the info

[ss01]

mine will be injectable to,how long do you run it bro?do you have to run it at least 12 weeks like normal GH?
thanx for the info

You can run it as long as you like. It all depends wether you run it between GH cycles or what.

[dream warrior]

i will run it with a.s and starting this stuff allready a few weeks before the cycle i want to see what this combo(a.s/ghrp-6)will bring

[Titan1]

UIs it injected IM or sq?

[dream warrior]

UIs it injected IM or sq?

i will inject it in IM in my shoulders but you can inject it SQ to

[ss01]

i will inject it in IM in my shoulders but you can inject it SQ to

Yes. Actually some state that SQ would be a bit better for lognger-duration GH spikes. I feel it is up to you.

[Carlito B]

Yes. Actually some state that SQ would be a bit better for lognger-duration GH spikes. I feel it is up to you.

correct!

2 to 3 times daily sub-q from 200mcgs to 500mcgs total daily. As a GH PCT use this Gh peptide for 3 to 4 weeks to help bring GH levels back to normal.

From my own experience using 400mcgs daily divided in 2 injections daily I experienced:

deeper better sleep
pronnounced increase of energy
mild increase of appetite
increase of sense of well being
somewhat noticable localized fat loss ( abdomen )


C

[dream warrior]

Yes. Actually some state that SQ would be a bit better for lognger-duration GH spikes. I feel it is up to you.

for my first i will do the shoulders and see if they grow better whit this in the long run

[Carlito B]

for my first i will do the shoulders and see if they grow better whit this in the long run

Bro, this GH releasing peptide will NOT cause localized muscle growth if that is what are expecting, is meant to go systemic therfore is best administered via subcutaneous injection ( sc/sub-q in abdomen )

Thanks,

C

[dream warrior]

Bro, this GH releasing peptide will NOT cause localized muscle growth if that is what are expecting, is meant to go systemic therfore is best administered via subcutaneous injection ( sc/sub-q in abdomen )

Thanks,

C

i know that it's not for local growth but that's what they say about winstrol /stanozolol to and it works good for me so that's why i wanted to give it a try
but maybe it has better effect when done sc/sub-q like you say
thanx for the help bro

[ss01]

i know that it's not for local growth but that's what they say about winstrol /stanozolol to and it works good for me so that's why i wanted to give it a try
but maybe it has better effect when done sc/sub-q like you say
thanx for the help bro

Yes it will have better effect that way. GHRP-6 has no effect on most tissue, it is effective (almost?) only on the pituitary, where it triggers a fairly massive amount of GH output. Then the GH goes into the body and does its thing.