IGF1-LR3 Basics

[jos]

I've read a bunch of the posts and I remain confused. If you don't mind, I'll ask a few questions to see what the consensus is.

I have IGF1-LR3 in powder form - 1000mcg. I have the water it came with and I also have bacteriostatic water that I grabbed from the pharmacy.

1) Can I simply reconstitute the 1000mcg of powder with 10ml's of bacteriostatic water? If so, how long will this be good for? I assume it needs to remain refrigerated? I'm leary of the vinegar method - sounds somewhat painful and non-sterile.

2) I travel a lot. I can take it with me but it won't be refrigerated for the time on the plane. Will this ruin it? Is it illegal to the point that airport security would become 'concerned'? (I know that 10ml's is less than the allowed 3 ounces - but they go ballistic if you don't separate it all out and show it to them...)

3) What's the best amount to inject? I've seen 4 units (0.04ml's) all of the way up to 1 full ml.

4) I've read that post workout (IMMEDIATELY post workout) site injection via IM is best. If you do a site injection, how do you split it up? Is the best amount to inject the best amount for each muscle or should it be split evenly over both sides? For example, in bi's, do you try to split it evenly in both heads of both biceps? Does it really make a difference if you hit all the heads or split it up over a large muscle or will it effectively spread regardless of the site(s) injected?

5) Should you use this every day? Only on days that you workout? Cardio days? How long should a good cycle be? How long between cycles?

Thanks in advance for the information. I'm sure there will be follow-up questions.

[jos]

I'm replying to my own post since no one else has. I've re-read some of the educational stuff. Taken alone, it seems to be quite clear. I've reproduced below. The problem is that many have come up with conflicting theories and I've not been able to determine from reading these posts which are best.

I will again ask, however, if 0.9% sodium chloride (bacteriostatic water) is an acceptable agent for reconstituting my IGF1-LR3. The various liquids mentioned in this article do not seem to include that - yet many, MANY of the posts indicate it is just fine and will last for up to a year.

Thanks for any help all of you can provide.

J

Copy of post from Educational Forum is below.
________________________________

IGF-1
When HGH makes it pass through the liver, a release of IGF-1 is a result. IGF-1 appears to be the key player in muscle growth. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. While HGH will cause an increase in your IGF-1 level over the course of a few months, HGH has a cumulative effect, so the addition of IGF-1 will greatly speed up the time to results.

There are two types of IGF-1 that will typically be used by bodybuilders. One is bio-identical huIGF-1, a 70 amino acid string. The other is Long R3 IGF-1, which is an 83 amino acid analog of human IGF-I comprising the complete human IGF-I sequence with the substitution of an Arg for the Glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus (hence the long). This 13 amino acid "side chain" helps prevent the IGF-1 from being so easily bound, and thus increases its active window exponentially. Which of these you use depends on your goal.

HuIGF-1 is very short lived in the body (half life of probably around 10 minutes). This type of IGF-1 is very useful if you are seeking local site growth. Since it is so short lived, little of the IGF-1 makes it to other tissues and IGF-1 receptors in the body. The way to inject this is immediately post work out into the muscle that you wish to have local site growth. Use a U100 insulin syringe, and inject 60-80mcg’s bilaterally into the desired muscle immediately post workout. For this type of IGF-1, I would use it workout days only or if desired you could inject on non-workout days first thing in the morning into a muscle group worked the previous day.

For Long R3 IGF-1, it isn’t as critical that you inject into a local site as long R3 has a active window of many hours, and is designed specifically to resist being bound by IGF binding proteins.

Since it is common to reconstitute this type of IGF-1 with Benzyl Alcohol, Acetic Acid, or Hydrochloric Acid, I would still recommend that you inject intra-muscular. While for some purposes of nerve regrowth, etc. subQ is a somewhat superior injection method, it can and probably will leave a nice red irritated spot if you inject subQ, and it is not superior for muscle growth purposes anyway.

I still inject into a muscle just worked to take advantage of increased IGF-1 receptors present as a result of tearing down muscles with workout, but because of the long activity window of this type of IGF-1 any muscle will work well and give you good results,. I would suggest that you inject between 40-80mcg’s per day everyday immediately post workout on workout days, and first thing in the morning on non-workout days.

Use a U-100 insulin syringe with 1/2" needle to inject IGF-1 intramuscular (bilaterally for HuIGF-1, bilaterally optional for Long R3)

[pimpdawgin]

If IGF-1 LR3 has a systemic (as opposed to a localized) effect AND a substancially longer half-life (due to LR3's propoerty of not being bound easily), why would it matter whether Intramuscular or subcutaneous injections were used?
As long as it's injected anywhere in the system, it will find its way to the receptors? Just asking, as I've never tried IM injections, and they scare me.
But otherwise, is there really a difference between the 2 methods?

[jos]

Everyone I've talked to (and all of the posts that I've read) recommend intra-muscular injection. I've heard that sub-cutaneous may be fine but that it often causes some skin irritation that takes a while to subside.

Why does IM scare you? That's what you do with almost all injectable AAS - but with this it is a MUCH smaller needle into the muscle so I would expect it to be almost imperceptible.

[pimpdawgin]

Everyone I've talked to (and all of the posts that I've read) recommend intra-muscular injection. I've heard that sub-cutaneous may be fine but that it often causes some skin irritation that takes a while to subside.

Why does IM scare you? That's what you do with almost all injectable AAS - but with this it is a MUCH smaller needle into the muscle so I would expect it to be almost imperceptible.

I've never tried AAS, so Idon't know what IM feels like. It goes deeper, so I figure more pain. But I know I'm freaking out over nothing. I was just asking is there a difference between the two, really.

[jos]

Don't freak out - a 1/2" needle into a the belly of muscle is nothing. And since IGF1 is reconstituted in (virtually) water, it will be very, very easy to inject (as compared with oil-based injections that require a bigger needle simply because you can't fit the liquid through a small insulin syringe).

But to your question - everyone I've talked to (including my brother-in-law who's been doing this for a while) suggests IM. You'll be very surprised - just make sure the muscle is relaxed when you inject. If its not, you may end up with a knot that will last for a day or two.

[jos]

I've found answers to most everything I've asked here. Here's the link:

http://forums.steroid.com/showthread...66#post3134266


Guys/gals reading this - the link above is very informative. Check it out. I wish things were easier to identify - it is impossible to read it all and I've found myself relying on the title/description to clue me in on whethere or not I should read it.

Here's what I now know:

IM injection with a 1/2" insulin needle post-workout. Can go daily or 5 days/week.

I'll be reconstituting with the acetic acid supplied with my IGF1. It is 1ml of acetic acid. So a typical dose would be 0.04 to 0.08ml's - 4 - 8 ticks on an insulin needle. Still unclear on whether or not bacteriostatic water would work - but my supplier told me that I had acetic acid (1ml) and I should use that.

Reconstituted with the acetic acid it will last several weeks/months. Won't need it for longer than 4 weeks. Must be refrigerated - so for me, traveling with it (unless I carry a cooler) is probably out of the question.

With LR3 it is not as important that you spread it evenly post workout but if you want, it may have some beneficial affect on the muscle injected. Just choose a spot (for instance, one head of the tri's) and do it on both sides.

Hope this helps for anyone - it has helped me a lot. If anyone finds any glaring errors in my summary above, please chime in.

Thanks-

J

[Columbus]

Link doesnt work bro.....did you start? What is the typical dose? Is it training days only?

[jos]

I've started. It has been 5 days.

I mixed with the 0.8ml of acetic acid that it came with. I did the math and got 60mcg from 0.05ml at that concentration. TINY amounts.

I've been doing site injection within an hour after my workouts w/ 1/2", 29g insulin syringe. On cardio days, I've done my legs. 0.025ml on each side. I'm going 7 days/week for 30 days (or thereabouts). I will be doing some traveling in between and will have to skip - too much hassle to carry it AND (more importantly) it is fragile once reconstituted so the knocking around of being in a cooler on an airplane will leave me with expensive water.

Give me some time to see what this does - if anything. I'll report back.