Best time 4 hgh

[phillifeline]

im currently doing 2 2iu jabs eod and im wondering when is the best time to take them ,

should it be on an empty stomach ?

wot are the best times of day to take it ?

any imput would be appreciated as this is my 1st hgh course

[RJstrong]

inject 1st thing in the morning and again right before bedtime (i'm sure there are varying opinions on this)... in regards to food intake No Carbs one hour before or after injection.

[plzr8]

For those that are between their late 20’s and early 50’s, there is still a reasonable chance that your own endogenous production of HGH is at a reasonable level. The best time to take and injection, this being the case, would be early morning …. After your body’s own release of HGH in the night. If you get up to go to the bathroom in the early morning (3 -5am), this is probably the perfect time to take a couple of units of HGH. This will be the least disruptive time to take an injection of HGH. The second best time would be first thing in the morning when you wake up.

If you are splitting your doses, the two times of the day when your cortisol levels are at peak are when you wake up and in the early afternoon. This being the case, another good strategy is to take your HGH injections at these times. Cortisol is very catabolic by nature and a well -timed HGH injection can go a long way toward blunting this effect.

taken directly from.....
My Guide to HGH for anyone interested

good luck!

[abrick]

inject 1st thing in the morning and again right before bedtime (i'm sure there are varying opinions on this)... in regards to food intake No Carbs one hour before or after injection.

How come no carbs one hour before or after injection?.....i've never read that before

[phillifeline]

so 1 wen i wake up n one mid afternoon , on an empty stomach

[plzr8]

so 1 wen i wake up n one mid afternoon , on an empty stomach

or just take the entire 4iu upon waking up on an empty stomach...much more convenient

[longhorn814]

or just take the entire 4iu upon waking up on an empty stomach...much more convenient

yeah no more two a day inject for me on HGH unless i start getting into high doses, 2-5 IU's one shot in the morning is fine

[phillifeline]

thought u were meant to spread it out to keep it in ur system ?

[plzr8]

thought u were meant to spread it out to keep it in ur system ?

aren't you doing eod injections? that seems to contradict what you are asking


IMO you should run it ED and shoot all 4iu upon waking up on an empty stomach

[phillifeline]

yeah eod , its my 1st course so im a little hazey on wot im gonna do myself

[plzr8]

yeah eod , its my 1st course so im a little hazey on wot im gonna do myself

understandable, there are many dosing protocols out there, everyone is different

once again tho, IMO i would suggest shooting either everyday or 6on/1off or 5on/2off...with all 4iu's upon waking up on an empty stomach....this is a typical protocol to follow

currently im running 5iu's everyday in AM

best of luck

[FranKieC]

How come no carbs one hour before or after injection?.....i've never read that before

Insulin sensitivity

[johnq]

understandable, there are many dosing protocols out there, everyone is different

once again tho, IMO i would suggest shooting either everyday or 6on/1off or 5on/2off...with all 4iu's upon waking up on an empty stomach....this is a typical protocol to follow

currently im running 5iu's everyday in AM

best of luck

sorry to jump in this post, what will you expect in gains off 5 ius a day. i just up mine to 5 ius? PLZR8

[FranKieC]

sorry to jump in this post, what will you expect in gains off 5 ius a day. i just up mine to 5 ius? PLZR8

You should start your own thread bro.

5iu is a nice dose, better recovery, Fat loss, well being ect

[plzr8]

sorry to jump in this post, what will you expect in gains off 5 ius a day. i just up mine to 5 ius? PLZR8

just like Frankie said....improved sense of well being, fat loss, etc..

in conjuction with test & another anabolics, hgh is a great tool....i have run a test + gh only cycle to really get a good look at the synergetic effect, and it really does vastly improve everything in my opinion (recovery, retaining gains, maintaing a low bf% when increasing cals, lbm, etc)

at 5 ius of GH alone, you will likely not see any serious mass or strength gains, but will eventually get many of hgh's beneficial effects......but throw in some test, and now your cookin'!

best of luck

[johnq]

cheers guys i just might do that

[abrick]

Insulin sensitivity

So after i get up at 7 am and take a few ius of gh and then eat breakfast...no oatmeal or any type of carbs for an hour?

[Microbrew]

I take 3ius 2x ed, when I wake up and about 2hrs after the gym. Don't want to take my shot to close to my PWO shake.

Micro

[BIG_T_MC06]

GH best taken before bed, the half life of GH is very short so it will not interfere with natty realase which can occur anywhere from 1-4 hours into sleep (something to do with REM)

A lot of people have been having great results running PWO also, either with other peptides (IGF/MGF and or slin)

BIG T

[ginkobulloba]

I switched from taking it at like 3-4 am to pwo. Whether it has made any difference is hard to tell. I still can eat a ridiculous amount of calories and stay lean while gaining weight. It's just easier than waking up and going to the fridge and messing around with vials and needles and alcohol and cotton swabs when I'm practically comatose. Then there are those nights where I forget to reconstitute the hgh before I sleep and I'm sitting there for like 15 minutes opening new vials when I should be dreaming. PWO is much easier and like I said, I haven't noticed any difference.

[SomeGirl]

Insulin sensitivity

really? good to know...

i take 2-4 ius first thing in the morning... then i usually realize its way too early and go back to sleep

[FranKieC]

really? good to know...

i take 2-4 ius first thing in the morning... then i usually realize its way too early and go back to sleep

lol I take mine as soon as I get up to get it out of the way. I go do cardio then come home and make my breakfast and by that time it's an hour and a half later.

[Miguel2013]

So what can happen if you take gh on a full stomach?

[Warrior1700]

For those that are between their late 20’s and early 50’s, there is still a reasonable chance that your own endogenous production of HGH is at a reasonable level. The best time to take and injection, this being the case, would be early morning …. After your body’s own release of HGH in the night. If you get up to go to the bathroom in the early morning (3 -5am), this is probably the perfect time to take a couple of units of HGH. This will be the least disruptive time to take an injection of HGH. The second best time would be first thing in the morning when you wake up.


If you are splitting your doses, the two times of the day when your cortisol levels are at peak are when you wake up and in the early afternoon. This being the case, another good strategy is to take your HGH injections at these times. Cortisol is very catabolic by nature and a well -timed HGH injection can go a long way toward blunting this effect.

taken directly from.....
My Guide to HGH for anyone interested

good luck!

That is the protocol I been using since hitting the 4IU mark, first thing when I wake up, 4 IUs. Done. Read this info also, good stuff on that site. I am on the 5/2

[Warrior1700]

GH best taken before bed, the half life of GH is very short so it will not interfere with natty realase which can occur anywhere from 1-4 hours into sleep (something to do with REM)

A lot of people have been having great results running PWO also, either with other peptides (IGF/MGF and or slin)

BIG T

GH is released from the pituitary , not the natty's if that is what your referencing? Has nothing to do with natty's. GH is released in a pulse, during sleep. Some take it at night as they say it helps them sleep (and dream vividly) but the article that Plzr8 referenced that up until your mid 50s, you may still be getting GH release at night so we don't want to interfere with that process by inj GH at night. But also stated, there are Many protocols and results so whatever works for you , do it. Most importantly, you should be consistent in when you take it.

[Red Bastard]

GH is released from the pituitary , not the natty's if that is what your referencing? Has nothing to do with natty's...

By "natty", I believe that he means natural. Not gonads...

[Othello]

Personally I feel the issue of night shots is age dependent.

If at a certain age your body is still producing natural gh, why take a risk and stop that? consider it as a bonus 1 IU FOC

research seems to indicate that up until age of 50 or so, normal human body still produces some amounts of gh at night, in the deep sleep time...also, info about duration of activity of HGH is sketchy...at least from what I have been able to read, many people provide contradictory info...so I play it safe at age 43...

I shoot first thing in the am...around 5:30 or 6:00...since I take T4 with shot, I wait for 1 - 1.5 hours before downing my fist cup of coffee (usually a latte - skimmed milk)...

then breakfast (protein shake, boiled egg whites etc) 30 min later (total of 2 hrs after shot).

[Warrior1700]

By "natty", I believe that he means natural. Not gonads...

Ohhhhh..DUH Lmao, thx.

[Warrior1700]

Personally I feel the issue of night shots is age dependent.

If at a certain age your body is still producing natural gh, why take a risk and stop that? consider it as a bonus 1 IU FOC

research seems to indicate that up until age of 50 or so, normal human body still produces some amounts of gh at night, in the deep sleep time...also, info about duration of activity of HGH is sketchy...at least from what I have been able to read, many people provide contradictory info...so I play it safe at age 43...

Correct, up to early 50s, we "May" still be producing GH, as Plzr8 stated in post and on the site that was referenced above. So for now, I am inj in the morning when I get up.

[marcus300]

Doesn't matter what time you take it, your natural hgh pulse is supressed anyway so you might aswell pin your hgh at night when your body needs it the most.

[Warrior1700]

Doesn't matter what time you take it, your natural hgh pulse is supressed anyway so you might aswell pin your hgh at night when your body needs it the most.

Crap, really? So even if we inj in the morning, 4 iu 5/2...it's suppressing out natural production at night? Like exogenous test suppresses out nat T?

[marcus300]

Crap, really? So even if we inj in the morning, 4 iu 5/2...it's suppressing out natural production at night? Like exogenous test suppresses out nat T?

The suppression comes from elevated IGF levels which last hours so if you are using gh for long periods of time your natural gh pulse is going to be blunted anyway. You also got to understand that there is a reason why the largest natural gh pulse is at night and how large is this pulse if the average man is producing lets says 1.5ius daily. So if your taking exogenous hgh at reasonable dose your natural gh is going to be suppressed and even if it wasn't suppressed its not worth saving anyway because you don't produce enough even if your night time pulse was half of your daily hgh output. So if all the growth factors and benefits happen during REM when our largest pulse is activated then why not follow your natural body's rhythm and inject the largest amount at night to get the most benefits out of your exogenous hgh.



Body composition response to exogenous GH during training in highly conditioned adults, D. M. Crist, J Appl Physiol 65: 579-584, 1988

Intro:
The effects of biosynthetic methionyl-human growth hormone (met-hGH) on body composition and endogenous secretion of growth hormone (GH) and insulin -like growth factor I (IGF-I) were studied in eight well-trained exercising adults between 22 and 33 yr of age for 6 weeks.


Dosing & Administration:
The met-hGH (experimental) treatment consisted of 8.0 mg (2 U/mg) per week of methGH (Protropin; Genentech, San Francisco, CA), which was divided into three doses (2.67 mg/dose) and delivered on alternate days (3 days/wk) in 0.5 ml of bacteriostatic diluent. Because of differences in the body weights of the subjects, the relative dose range varied between 0.03 and 0.05 mg/kg per injection. Injections were given between 0800 and 1500, and their delivery was rotated among four to six sites throughout the study period. Treatments were administered on a double-blind basis with neither the experimental subject nor the person administering the injections knowing which treatment was being delivered. The total weekly dose of met-hGH used in this study (8.0 mg) was considered supraphysiological, since the spontaneous release of human GH during a 24-h period is purportedly -0.68 mg (4.8 mg/wk) in men and 0.79 mg (5.5 mg/wk) in women (30), similar to amounts reported by others (6).


CONCLUSION
In the present study, we found that alternate-day treatment with met-hGH altered body composition in highly conditioned, exercising adults by increasing FFW (fat free weight), decreasing %fat, and increasing FFW (fat free weight)/FW (fat weight). These changes were significantly greater than those produced by exercise alone.
...
Moreover we found that supraphysiological amounts of met-hGH were sufficient to significantly elevate circulating concentrations of IGF-I in all our subjects, confirming that the changes in body composition were indeed due to real alterations produced in vivo by the hormone treatment.


Supression of endogenous GH
It has been reported previously that exogenous GH will suppress endogenous release of the hormone (19,23) and that this effect may be mediated in part by elevated levels of IGF-I (23). On a preliminary basis, we found that treatment for 6 wk with supraphysiological doses of met-hGH produced an impaired endogenous GH response to stimulation in some, but not all, of our subjects. This variable response may be related to the amount of hormone used in the study. Although a significant group elevation in IGF-I levels occurred during the met-hGH treatment, this response was still below the upper limit of normal (2.20 U/ml) for the study group. Thus it is plausible that the treatment dose of met-hGH used and the subsequent moderate increase in IGF-I levels led to feedback suppression of endogenous GH release in five of the seven subjects measured for this effect, whereas these physiological events were insufficient to produce this effect in two of the subjects.


Intense exercise increases sensitivity to GH??
...One possible explanation for the disparity between our findings and those of others (25, 26) is that the stress of long-term, intensive exercise training could induce alterations in vivo, which might potentiate tissue sensitivity to the physiological actions of GH (2). In any case, it is clear from our findings that supraphysiological doses of met-hGH increased circulating concentrations of IGF-I and increased FFW (fat free weight) and decreased FW (fat weight) in highly conditioned, exercising adults.


Soft-tissue Overgrowth?
There are two principal adverse reactions associated with excessive amounts of human GH, carbohydrate intolerance, and soft-tissue overgrowth. In the present study, we measured fasting blood glucose levels periodically throughout each treatment and found no real changes suggestive of a hyperglycemic response to methGH. Because soft-tissue overgrowth is associated with abnormally high levels of IGF-I, the normal responses observed suggest that the chance for soft-tissue overgrowth occurring in our subjects was minimal. However, it is unreasonable to conclude that use of met-hGH is safe as an adjunct to exercise in healthy adults until more subjects are studied over longer periods of time and with more stringent tests for detecting changes in glucose tolerance and soft-tissue overgrowth.


Diet used
To avoid compromising the dietary requirements for optimal tissue anabolism during the met-hGH treatment, our subjects ingested between 2.05 and 2.10 g/kg a day of protein and a minimum number of kilocalories to maintain body weight. The kilocaloric requirement removed the potential bias from a dietary-induced FW loss.


In Conclusion
We conclude that treatment with supraphysiological doses of met-hGH will significantly alter body composition in adults who are highly conditioned from years of exercise training. The magnitude of this effect, however, is dependent in part on the amount of hormone given per body weight of the individual rather than endogenous GH secretory status. Changes in body composition are directly related to met-hGH administration, but the manifestations of treatment may be mediated in part by increased production of IGF-I or other GH-dependent serum anabolic factors. Moreover, supraphysiological treatment with met-hGH in exercising adults may produce impairments in the stimulated release of endogenous GH in some individuals.

[Warrior1700]

OK then...Good stuff, thanks Marcus, looks like starting Mon I'll inj at night before bed. I'm 50 1/2 now anyway, so if it's benefits me more, then great. Also been reading it helps sleep. I wear a Cpap as it is so this can't hurt.

[Warrior1700]

Doesn't matter what time you take it, your natural hgh pulse is supressed anyway so you might aswell pin your hgh at night when your body needs it the most.

Ok, so...If I start inj at night, should it be just before bed(sleep) and not an hour or 2 before sleep. I work afternoons and got home bout 1130, and go to bed bout 1am. However, I sometimes have a girl over or I go there, so I would not always be home when going to bed. I would be home right after work by 1130pm either way as I come hoe first if I go the girl. Or should I stick with morning when I can be more consistent?

[playapanda]

I do 4.5iu 6 days a week right before I go to bed and have seen fat loss and muscle gain.

[Warrior1700]

Bump...

Correct, up to early 50s, we "May" still be producing GH, as Plzr8 stated in post and on the site that was referenced above. So for now, I am inj in the morning when I get up.

Ok, so...If I start inj at night, should it be just before bed(sleep) and not an hour or 2 before sleep. I work afternoons and got home bout 1130, and go to bed bout 1am. However, I sometimes have a girl over or I go there, so I would not always be home when going to bed. I would be home right after work by 1130pm either way as I come hoe first if I go the girl. Or should I stick with morning when I can be more consistent?

[Jiggylow]

The suppression comes from elevated IGF levels which last hours so if you are using gh for long periods of time your natural gh pulse is going to be blunted anyway. You also got to understand that there is a reason why the largest natural gh pulse is at night and how large is this pulse if the average man is producing lets says 1.5ius daily. So if your taking exogenous hgh at reasonable dose your natural gh is going to be suppressed and even if it wasn't suppressed its not worth saving anyway because you don't produce enough even if your night time pulse was half of your daily hgh output. So if all the growth factors and benefits happen during REM when our largest pulse is activated then why not follow your natural body's rhythm and inject the largest amount at night to get the most benefits out of your exogenous hgh.



Body composition response to exogenous GH during training in highly conditioned adults, D. M. Crist, J Appl Physiol 65: 579-584, 1988

Intro:
The effects of biosynthetic methionyl-human growth hormone (met-hGH) on body composition and endogenous secretion of growth hormone (GH) and insulin -like growth factor I (IGF-I) were studied in eight well-trained exercising adults between 22 and 33 yr of age for 6 weeks.


Dosing & Administration:
The met-hGH (experimental) treatment consisted of 8.0 mg (2 U/mg) per week of methGH (Protropin; Genentech, San Francisco, CA), which was divided into three doses (2.67 mg/dose) and delivered on alternate days (3 days/wk) in 0.5 ml of bacteriostatic diluent. Because of differences in the body weights of the subjects, the relative dose range varied between 0.03 and 0.05 mg/kg per injection. Injections were given between 0800 and 1500, and their delivery was rotated among four to six sites throughout the study period. Treatments were administered on a double-blind basis with neither the experimental subject nor the person administering the injections knowing which treatment was being delivered. The total weekly dose of met-hGH used in this study (8.0 mg) was considered supraphysiological, since the spontaneous release of human GH during a 24-h period is purportedly -0.68 mg (4.8 mg/wk) in men and 0.79 mg (5.5 mg/wk) in women (30), similar to amounts reported by others (6).


CONCLUSION
In the present study, we found that alternate-day treatment with met-hGH altered body composition in highly conditioned, exercising adults by increasing FFW (fat free weight), decreasing %fat, and increasing FFW (fat free weight)/FW (fat weight). These changes were significantly greater than those produced by exercise alone.
...
Moreover we found that supraphysiological amounts of met-hGH were sufficient to significantly elevate circulating concentrations of IGF-I in all our subjects, confirming that the changes in body composition were indeed due to real alterations produced in vivo by the hormone treatment.


Supression of endogenous GH
It has been reported previously that exogenous GH will suppress endogenous release of the hormone (19,23) and that this effect may be mediated in part by elevated levels of IGF-I (23). On a preliminary basis, we found that treatment for 6 wk with supraphysiological doses of met-hGH produced an impaired endogenous GH response to stimulation in some, but not all, of our subjects. This variable response may be related to the amount of hormone used in the study. Although a significant group elevation in IGF-I levels occurred during the met-hGH treatment, this response was still below the upper limit of normal (2.20 U/ml) for the study group. Thus it is plausible that the treatment dose of met-hGH used and the subsequent moderate increase in IGF-I levels led to feedback suppression of endogenous GH release in five of the seven subjects measured for this effect, whereas these physiological events were insufficient to produce this effect in two of the subjects.


Intense exercise increases sensitivity to GH??
...One possible explanation for the disparity between our findings and those of others (25, 26) is that the stress of long-term, intensive exercise training could induce alterations in vivo, which might potentiate tissue sensitivity to the physiological actions of GH (2). In any case, it is clear from our findings that supraphysiological doses of met-hGH increased circulating concentrations of IGF-I and increased FFW (fat free weight) and decreased FW (fat weight) in highly conditioned, exercising adults.


Soft-tissue Overgrowth?
There are two principal adverse reactions associated with excessive amounts of human GH, carbohydrate intolerance, and soft-tissue overgrowth. In the present study, we measured fasting blood glucose levels periodically throughout each treatment and found no real changes suggestive of a hyperglycemic response to methGH. Because soft-tissue overgrowth is associated with abnormally high levels of IGF-I, the normal responses observed suggest that the chance for soft-tissue overgrowth occurring in our subjects was minimal. However, it is unreasonable to conclude that use of met-hGH is safe as an adjunct to exercise in healthy adults until more subjects are studied over longer periods of time and with more stringent tests for detecting changes in glucose tolerance and soft-tissue overgrowth.


Diet used
To avoid compromising the dietary requirements for optimal tissue anabolism during the met-hGH treatment, our subjects ingested between 2.05 and 2.10 g/kg a day of protein and a minimum number of kilocalories to maintain body weight. The kilocaloric requirement removed the potential bias from a dietary-induced FW loss.


In Conclusion
We conclude that treatment with supraphysiological doses of met-hGH will significantly alter body composition in adults who are highly conditioned from years of exercise training. The magnitude of this effect, however, is dependent in part on the amount of hormone given per body weight of the individual rather than endogenous GH secretory status. Changes in body composition are directly related to met-hGH administration, but the manifestations of treatment may be mediated in part by increased production of IGF-I or other GH-dependent serum anabolic factors. Moreover, supraphysiological treatment with met-hGH in exercising adults may produce impairments in the stimulated release of endogenous GH in some individuals.

great comprehensive post, very informative and it makes a lot of sense to other because it provides some reasoning... thanks.