191aa rHGH may cause cause Antibodies

This is direct from www.drugs.com

It is intended for medical professionals as a guideline. According to the article below in reference to 191aa Nutropin manufactured in the USA by Genetech, "As with all protein pharmaceuticals, a small number of patients may develop antibodies to the protein." It also mentions injection site rash from benzyl alcohol sensitive individuals.

http://www.drugs.com/sfx/nutropin-aq-side-effects.html

[quote]For the professional


Nutropin AQ

As with all protein pharmaceuticals, a small percentage of patients may develop antibodies to the protein. GH antibody binding capacities below 2 mg/L have not been associated with growth attenuation. In some cases when binding capacity exceeds 2 mg/L, growth attenuation has been observed.

And another for Somatropin

http://www.drugs.com/ppa/somatropin.html

Quote:

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Adverse Reactions

CNS

Headache; weakness; recurrent growth of intracranial tumor.
Dermatologic

Rash; urticaria; pain; inflammation at injection site.
Genitourinary

Glucosuria; hypercalciuria.
Metabolic

Hypothyroidism; hyperglycemia.
Miscellaneous

Localized muscle pain; mild, transient edema; antibodies to growth hormone.

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And another for Humatrope

http://www.drugs.com/pro/humatrope.html#section-9

Quote:

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Adverse Reactions

Growth Hormone-Deficient Pediatric Patients

As with all protein pharmaceuticals, a small percentage of patients may develop antibodies to the protein. During the first 6 months of Humatrope therapy in 314 naive patients, only 1.6% developed specific antibodies to Humatrope (binding capacity ≥0.02 mg/L).

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And another for Tev-Tropin

http://www.**list.com/cgi/generic/tev-tropin_ad.htm

Quote:

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Utilizing a double-antibody immunoassay, no antibodies to growth hormone could be detected in a group of 164 naïve and previously treated clinical trial patients after treatment with TEV-TROPINÃ? for up to 40 months. However, utilizing the less specific polyethelene glycol (PEG)precipitation immunoassay,27 of the 164 patient group were tested after treatment with TEV-TROPINÃ? for 4 to 6 months and antibodies to growth hormone were detected in two patients (7.4%)

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This is old news, but a good post to have up. It's something most people only think is related to 192aa.