how long should cjc1295/ghrp-6 be run without tiring the pituatary?

[mickdiesel]

with clen , u exacerbate your CNS and must take time off. does the same go for these peotides? cuz im assuming u have to give the pituatary a rest or itll "burn out".

any thoughts, facts, etc?

thanks guys

[mickdiesel]

nothin guys?

[mickdiesel]

bump

[mickdiesel]

so noone knows or its f@%k mick week?

cuz lots of people are looking but noones talking

[ScotchGuard]

I've been keeping up with this thread to get some answers. I don't know the answer and I think the answer's worth knowing.

[OH REALLY]

i think it would but no one knows for sure .... but thats why i stopped using it..

[BJJ]

no clue, sorry.

[elpropiotorvic]

i found this hope it helps


J Clin Endocrinol Metab. 2006 Mar;91(3):799-805. Epub 2005 Dec 13.

Prolonged stimulation of growth hormone (GH) and insulin -like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.
Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA.

WinPharm Associates, Alamo, CA 94507, USA.

CONTEXT: Therapeutic use of GHRH to enhance GH secretion is limited by its short duration of action. OBJECTIVE: The objective of this study was to examine the pharmacokinetic profile, pharmacodynamic effects, and safety of CJC-1295, a long-acting GHRH analog. DESIGN: The study design was two randomized, placebo-controlled, double-blind, ascending dose trials with durations of 28 and 49 d. SETTING: The study was performed at two investigational sites. PARTICIPANTS: Healthy subjects, ages 21-61 yr, were studied. INTERVENTIONS: CJC-1295 or placebo was administered sc in one of four ascending single doses in the first study and in two or three weekly or biweekly doses in the second study. MAIN OUTCOME MEASURES: The main outcome measures were peak concentrations and area under the curve of GH and IGF-I; standard pharmacokinetic parameters were used for CJC-1295. RESULTS: After a single injection of CJC-1295, there were dose-dependent increases in mean plasma GH concentrations by 2- to 10-fold for 6 d or more and in mean plasma IGF-I concentrations by 1.5- to 3-fold for 9-11 d. The estimated half-life of CJC-1295 was 5.8-8.1 d. After multiple CJC-1295 doses, mean IGF-I levels remained above baseline for up to 28 d. No serious adverse reactions were reported. CONCLUSIONS: Subcutaneous administration of CJC-1295 resulted in sustained, dose-dependent increases in GH and IGF-I levels in healthy adults and was safe and relatively well tolerated, particularly at doses of 30 or 60 microg/kg. There was evidence of a cumulative effect after multiple doses. These data support the potential utility of CJC-1295 as a therapeutic agent.

PMID: 16352683 [PubMed - indexed for MEDLINE]

[The Deuce]

They can be run indefinitely and depending on your goals and results is what determines the length of your proposed cycle.. some go 4 months, others 6, even 9 months.. I know a bunch who don't plan on ceasing until they retire from their sport.. and I know some that do a 6 week on 2 week off protocol.. it is always and only GOAL DEPENDENT...

Hope that helps.

[The Deuce]

Oh one other thing.. run GHRP-2.. not the 6... it's an all around BETTER PEP .. especially when running cjc-1295 with it. FYI..

[ScotchGuard]

I've done quite a bit of research and I've not found a definitive study which answers the question of the affects of long term CJC/GHRP usage. All of the papers agree that CJC/GHRP stimulates the release of GH. Apparently, there is an increase in appetite due to the increase of Ghrelin. One paper talked about using GHRP to re-stimulate your pituitary after long term synthetic HGH use which could suppress the natural production of GH.

I figure that ANYTHING introduced to the endo system that is synthetically manufactured will disrupt the natural balance of the body. The question is how much? As we get older our P slows the production of GH. As we get older we just have less GH production to "burn out". I've read very experienced people on this board advising young people (under 30) not to start HGH because of the potential to disrupt the natural GH production levels. I've also experienced awesome benefits of HGH as a middle aged man. My unscientific conclusion is that GHRP-2/CJC/GHRP-6 is similar to HGH in that it follows similar rules. 1. Don't hurry into it before you're 30. 2. Cycle into it slowly. 3. Avoid sugars 1hr before and 1 hr after injection. 4. It's a long term commitment (6 months)

I think it would be a good idea to go 6 months on HGH and 6 months on GHRP/CJC. One is synthetic HGH and slows down the secretion of natural GH. The other is a peptide that stimulates the secretion of natural GH. But the bottom line is that until there is a clinical double blind long term study we're all depending on the experience of users to keep up informed.

[DCannon]

As we get older our P slows the production of GH. As we get older we just have less GH production to "burn out".

I remember reading somewhere that your pituitary always pruduces the same amount of gh, it just starts to release less for whatever reason.