Sarms s-22

[Hondarocks]

Selective Androgen Receptor Modulators (SARMs ) as Function Promoting Therapies
Shalender Bhasin, MD and Ravi Jasuja, PhD
Section of Endocrinology, Diabetes, and Nutrition, Boston Claude D. Pepper Older Americans Independence Center for Function Promoting Therapies, Boston University School of Medicine
Contact Information: Shalender Bhasin, MD, Section of Endocrinology, 670 Albany Street, Second Floor, Boston Medical Center, Boston, MA 02118, Email: [email protected]
The publisher's final edited version of this article is available at Curr Opin Clin Nutr Metab Care
See other articles in PMC that cite the published article.
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Abstract
Purpose of review

The last decade has witnessed unprecedented discovery effort to develop selective androgen receptor modulators (SARMs) that improve physical function and bone health without adversely affecting the prostate and cardiovascular outcomes. This review describes the historical evolution, the rationale for SARM development, and the mechanisms of testosterone action and SARM selectivity.
Recent Findings

While steroidal SARMs have been around since the 1940s, a number of nonsteroidal SARMs that do not serve as substrates for CYP19 aromatase or 5α-reductase, act as full agonists in muscle and bone and as partial agonists in prostate are in development. The differing interactions of steroidal and nonsteroidal compounds with AR contribute to their unique pharmacologic actions. Ligand binding induces specific conformational changes in the ligand binding domain, which could modulate surface topology and protein-protein interactions between AR and coregulators, resulting in tissue-specific gene regulation. Preclinical studies have demonstrated the ability of SARMs to increase muscle and bone mass in preclinical rodent models with varying degree of prostate sparing. Phase I trials of SARMs in humans have reported modest increments in fat-free mass.
Summary

SARMs hold promise as a new class of function promoting anabolic therapies for a number of clinical indications, including functional limitations associated with aging and chronic disease, frailty, cancer cachexia, and osteoporosis.

Source: NIH

[Hondarocks]

SARMS S-22 works like Steroids without the Side effects.
Forget about hgh, testosterone or other steroids.
The future is already here, neurotrophics enhancing your memory, intelligence, reflexes (cognitive enhancement),
strength, muscles, height (also after growth plate fusion) and whatever already exist, you just need the money.

Looks very promising, might be better than GH and anabolics, anyone tried it?

[im83931]

Many guys have tried these already. imo- they are over hyped and under delivered on results. I wouldn't run them at all.

[Hondarocks]

Damn that sucks