Are you new to peptides? curious about IGF1LR3 or others? Here is some good info-->

[Blergs]

I posted this at another place and thought maybe it would help some one here also.


Are you new to Peptides? Here is some Info you might want to get started with --->

I think peptides can be VERY useful to people want help with their bodies.
Peptides can help with repair, recovery and for some, energy also.
But not all peptides are the same. Some don’t give growth at all!
For e.g. MT2, it would darken the skin, but would have nothing to do with gains or recovery.
Another is HGH-frag, it may aid in fat loss but that’s about it.
Yah you thought by looking at it this one would be the one for gains, I know.
But that’s why you NEED to know about every general peptide out there, at least some basics of each one and if you plan to do lab studies with them then even more research should be done of that specific one. This is just a safer way to go about it, rather than picking one blindly and going with it. I know you are not doing that or you would not be here reading.
But there are others out there that would, I assure you on that.

What is my TOP peptide? I would have to say IGF1LR3.
I feel it’s even better than the FDA/Gov. controlled hGH out on the market, in terms of gains and growth.
Some will argue this, but it’s MY opinion.
That’s not to say that hGH is not good, sure it is.
But from a cost to affect ratio, I do not believe this is the case and I lean towards IGF1LR3, at least right now.
Sounds nice? At the end of this post I will post some info I have on IGF1LR3 and maybe a couple more.
So there are A LOT of peptides out there huh?
I sure know it was confusing when I first looked at them years ago, and there was LESS information on them at the time which just made things worse.
Another thing, a VERY important thing is QUALITY of the peptide.
So cheaper IS NOT always better! So make sure you do your research before buying from anywhere.

Well I will list my TOP 4 peptides for grow from best to least to help you out with a starter list to study:
#1 IGF1LR3 (long acting, long life span)
#2 GHRP-2
#3 CJC-1295
#4 IGF1 Des (short acting, short lifespan)
I feel these are some of the most beneficial of the peptides out there right now.
Below I will list some basic info on these peptides.
Also feel free to PM me if you have any questions, do I know everything? Nope, but I know a heck of a lot about peptides from my studies and lab tests over the years, so anyone I may be able to help, I’d be glad to.

[Blergs]

IGF1 and IGF1LR3



IGF stands for insulin-like growth factor. Insulin-like growth factor 1 (IGF-1) is a polypeptide protein hormone similar in molecular structure to insulin . It plays an important role in childhood growth and continues to have effects in adults. It is a natural substance that is produced in the human body and is at its highest natural levels during puberty. During puberty IGF is the most responsible for the natural muscle growth that occurs during these few years. There are many different things that IGF does in the human body. Among the effects the most positive are increased amino acid transport to cells, increased glucose transport, increased protein synthesis, decreased protein degradation, and increased RNA synthesis.
Long R3 IGF-1 is signifacantly more potent than IGF-1. The enhanced potency is due to the decreased binding of Long R3 IGF-1 to all known IGF binding proteins. These binding proteins normally inhibit the biological actions of IGF's. When IGF is active it behaves differently in different types of tissues. In muscle cells proteins and associated cell components are stimulated. Protein synthesis is increased along with amino acid absorption. As a source of energy, IGF mobilizes fat for use as energy in adipose tissue. In lean tissue,

IGF prevents insulin from transporting glucose across cell membranes. As a result the cells have to switch to burning off fat as a source of energy.
IGF also mimic's insulin in the human body. It makes muscles more sensitive to insulin's effects, so if you are a person that currently uses insulin you can lower your dosage by a decent margin to achieve the same effects, and as mentioned IGF will keep the insulin from making you fat.
The most effective form of IGF is Long R3 IGF-1, it has been chemically altered and has had amino acid changes which cause it to avoid binding to proteins in the human body and allow it to have a much longer half life, around 20-30 hours. "Long R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substition of an Arg(R) for the Glu(E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. This analog of IGF-1 has been produced with the purpose of increasing the biological activity of the IGF peptide."
IGF Cycles
The most effective length for a cycle of IGF is 50 days on and 20-40 days off. The most controversy surrounding Long R3 IGF-1 is the effective dosage.
IGF Dosage
The most used dosages range between 20mcg/day to 120+mcg/day. IGF is only available by the milligram, one mg will give you a 50 day cycle at 20mcg/day, 2mg will give you a 50 day cycle at 40mcg/day, 3mg will give you a 50 day cycle at 60mcg/day, 4mg will give you a 50 day cycle at 80mcg/day and so on. The dosage issue mainly revolves around how much money you have to spend, plenty of people use the minimum dosage of 20mcg/day and are happy with the results. IGF is most effective when administered subcutaneous and injected once or twice daily at your current dosage. The best time for injections is either in the morning and/or immediately after weight training (if used for body building).
IGF Effects and Results
Perhaps the most interesting and potent effect IGF has on the human body is its ability to cause hyperplasia, which is an actual splitting of cells. Hypertrophy is what occurs during weight training and steroid use, it is simply an increase in the size of muscle cells. See, after puberty you have a set number of muscle cells, and all you are able to do is increase the size of these muscle cells, you don't actually gain more. But, with IGF use you are able to cause this hyperplasia which actually increases the number of muscle cells present in the tissue. So in a way IGF can actually change your genetic capabilities in terms of muscle tissue and cell count. IGF proliferates and differentiates the number of types of cells present. At a genetic level it has the potential to alter an individuals capacity to build superior muscle density and size.

Another frequently asked question of IGF refers to the real world results. With an effective dosage you can expect to gain 1-2 lbs of new lean muscle tissue every 2-3 weeks. Increased vascularity is also very common, people report seeing veins appear where they never have before.
Overall, IGF is a very exciting drug due to its ability to alter ones genetic capabilities.

[Blergs]

Growth Hormone Releasing Peptide - 2 (GHRP2)

Is a synthetic six amino acid peptide that has robustly potent properties.
GHRPs are a small family of peptides acting at the pituitary and the hypothalamus to release Growth hormone (GH) through the activation of a specific, G protein-coupled receptor.

They were discovered 20 years ago as synthetic metenkephalin- derived oligopeptides (Synthetic tissue derived amino acids). Although it has no structural homology with Growth Hormone Releasing Hormone (GHRH), in clinical studies GHRP-2 demonstrated action on the pituitary to release Human Growth Hormone (HGH). Similar results were effective when GHRP-2 was administered sublingual. Clinical studies showed the most potent GHRP being the hexapeptide GHRP-2.

Growth Hormone Releasing Peptide 2(GHRP2) substantially stimulates the pituitary gland's increased natural production of the body's own endogenous human growth hormone (HGH). This therapy consists of daily periodic sub-lingual dosing. Growth Hormone releasing peptide 2, GHRP2 has shown on it's own to robustly increase igf-1 levels, and even greater results occurred when used with Growth Hormone Releasing Hormone (GHRH) to which also stimulates the pituitary gland to produce increased natural secretion of human growth hormone. This also boosts the hypothalamus function as well.

The results of the clinical studies published in the Journal of Endocrinology and Metabolism in 1997 for GHRP2 - showed that a medically supervised, prescribed and administered therapy increased growth hormone levels in adults and children, who have growth hormone deficiency.

The increase in the body's growth hormone via elevated igf-1 levels produced by the pituitary gland in response to GHRP2 therapy -- has an anabolic effect on the tissues of the body and other benefits identified below.
Synergy of GHRH + GHRP

It is well documented and established that the concurrent administration of Growth Hormone Releasing Hormone (GHRH) and a Growth Hormone Releasing Peptide (Ghrp-6, GHRP-2 or hexarelin) results in synergistic release of GH from pituitary stores. In other words if GHRH contributes a GH amount quantified as the number 2 and GHRPs contributed a GH amount quantified as the number 4 the total GH release is not additive (i.e. 2 + 4 = 6). Rather the whole is greater than the sum of the parts such that 2 + 4 = 10.

While the GHRPs (Ghrp-6, GHRP-2 and hexarelin) come in only one half-life form and are capable of generating a GH pulse that lasts a couple of hours re-administration of a GHRP is required to effect additional pulses.

Growth Hormone Releasing Hormone (GHRH) however is currently available in several forms which vary only by their half-lives. Naturally occurring GHRH is either a 40 or 44 amino acid peptide with the bioactive portion residing in the first 29 amino acids. This shortened peptide identical in behavior and half-life to that of GHRH is called Growth Hormone Releasing Factor and is abbreviated as GRF(1-29).

GRF(1-29) is produced and sold as a drug called Sermorelin. It has a short-half life measured in minutes. If you prefer analogies think of this as a Testosterone Suspension (i.e. unestered).

To increase the stability and half-life of GRF(1-29) four amino acid changes where made to its structure. These changes increase the half-life beyond 30 minutes which is more than sufficient to exert a sustained effect which will maximize a GH pulse. This form is often called tetrasubstituted GRF(1-29) (or modified) and unfortunately & confusingly mislabeled as cjc-1295. If you prefer analogies think of this as a Testosterone propionate (i.e. short-estered).

Note that some may also refer to this as cjc-1295 without the DAC (Drug Affinity Complex).

Frequent dosing of either the aforementioned modified GRF(1-29) or regular GRF(1-29) is required and as previously indicated works synergistically with a GHRP.

In an attempt to create a more convenient long-lasting GHRH, a compound known as cjc-1295 was created. This compound is identical to the aforementioned modified GRF(1-29) with the addition of the amino acid Lysine which links to a non-peptide molecule known as a "Drug Affinity Complex (DAC)". This complex allows GRF(1-29) to bind to albumin post-injection in plasma and extends its half-life to that of days. If you prefer analogies think of this as a Testosterone cypionate (i.e. long-estered). However this is not accurate. cjc-1295 results in continual GH bleed. Although natural pulsation still occurs cjc-1295 does nothing to increase those pulses. Instead it raises base levels of GH and creates a more feminized pattern of release. This not desirable.

Modified GRF(1-29)however when combined with a GHRP brings about a substantial pulse which has desirable effects.

A Brief Summary of Dosing and Administration

Dosing GHRPs (IN LAB TESTING IN PASSED)

The saturation dose in most studies on the GHRPs (Ghrp-6, GHRP-2, Ipamorelin & hexarelin) is defined as either 100mcg or 1mcg/kg.

What that means is that 100mcg will saturate the receptors fully, but if you add another 100mcg to that dose only 50% of that portion will be effective. If you add an additional 100mcg to that dose only about 25% will be effective. Perhaps a final 100mcg might add a little something to GH release but that is it.

So 100mcg is the saturation dose and you could add more up to 300 to 400mcg and get a little more effect.

A 500mcg dose will not be more effective then a 400mcg, perhaps not even more effective then 300mcg.

The additional problems are desensitization & cortisol/prolactin side-effects.

[Blergs]

CJC 1295
CJC 1295 is a peptide of 29 amino acid length, primarily functioning as a growth hormone releasing hormone (GHRH) analog. cjc-1295 represents a very exciting new compound that has the potential to increase growth hormone and IGF-I secretion and effects. CJC - 1295 Stimulates GH and igf-1 Secretion, and will keep a steady increase of HGH and igf-1 with no increase in prolactin, leading to intense fat loss, and increases protein synthesis for more muscle growth.

cjc-1295 is a synthetic modification of growth hormone releasing factor (GRF) with D-Ala, Gln, Ala, and Leu substitutions at positions 2, 8, 15, and 27 respectively. These substitutions create a much more stable peptide. By applying the Drug Affinity Complex (DAC) technology to GRF, the peptide selectively and covalently binds to circulating albumin after subcutaneous (SC) administration, thus prolonging its half-life.

These substitutions are key to increasing the overall half life of cjc-1295 but there lies an even greater reason as to why the half life has been extended. Bioconjugation is a relatively newer technology that takes a reactive group and attaches it to a peptide, which in turn reacts with a nucleophilic (usually a partially negative molecule) entity found in the blood to form a more stable bond.

In fact, bioconjugation is so effective that there was less than 1% of cjc-1295 left unreacted in vivo and over 90% was stabilized after subcutaneous injection. This means that you get more of what you paid for working for you.

With an increased half life cjc-1295 can provide intense fat loss along with increased protein synthesis for even more muscle growth.

[snowblowjoe]

I am trying to PM you but am new to the forum and can't find the pm button. I'm getting IGF-1 Lr3 (Lyophilized) 1mg, and was wondering do I need to worry about my estrogen levels? Do I need to buy Arimidex or Nolvadex? Also I am already starting to lose hair so losing anymore is unacceptable, should I get a DHT blocker? What supplements do I need to get to decrease the side effects the most and increase the positives the best? I am currently on a clenbuterol and ketotifen cycle. Also will mix in albuterol with keto to switch it up. Thanks in advance!

[ADSONE]

Great info...just like snow... I wondered the same thing, any estrogenic sides or just running 50 day cycle be good enough?

[urfoolishness]

thanks for the info. have you any experience with myostatin inhibitors? follistatin or the other new ones? im thinking about putting together a cycle to try between heavy aas cycles, to give liver and kidneys a good break but still make gains. im sold on igf-1 lr3 but want to add some more kick.

[abubuu13]

Blergs

Awesome info thanks....quick question: I currently take Sermorelin 200mg/day but buy it from a Pharmacy in Florida ($600/month). Are the peptides sold as "research only" the same as what I pay ou the nose for? Being a scientist myself I know in our field "research only" is usually only stated to keep from being sued......or is there really something in the pharmaceutical brand that makes it ok for human use?

[Blergs]

Blergs

Awesome info thanks....quick question: I currently take Sermorelin 200mg/day but buy it from a Pharmacy in Florida ($600/month). Are the peptides sold as "research only" the same as what I pay ou the nose for? Being a scientist myself I know in our field "research only" is usually only stated to keep from being sued......or is there really something in the pharmaceutical brand that makes it ok for human use?

I feel that question is too general to answer, but if the seller is an honest place then the compounds should be what they are labelled as, regardless if they are for human or non human use.

hope that helps

[Blergs]

thanks for the info. have you any experience with myostatin inhibitors? follistatin or the other new ones? im thinking about putting together a cycle to try between heavy aas cycles, to give liver and kidneys a good break but still make gains. im sold on igf-1 lr3 but want to add some more kick.

Still too new and unpredictable in my op, but It seems there is ALOT of stuff developing right now and at a snow balling effect of speed!
So I dont have much to say on that subject right now but with all the new info and compounds comming out I will be touching on that some time soon I am sure.
Right now I dont feel I have the right to make much comments on that type of compound (I need more research because so much as changed on that topic) other then I am looking foward to finding useful compounds and info on it in the comming months-yrs.
And I WILL be sure to post it here when the time comes and hopfully help someone out.

I LOVE and HIGHLY rec IGF1 Des and/or IGF1LR3.
I really do enjoy it on a teste/maste cycle. (even on my current TrenE/testE cycle is/was pretty nice)

ENJOY!

[urfoolishness]

thanx for the honesty. i have been doing some research on ace-031. it looks like the clinical trials had very dramatic results initially, but due to some "MILD" adverse effects they stopped. the amounts they were using seem crazy, 1mg /kg injected im once every 2 to 4 weeks. im kinda paraphrasing but the subjects gained 5% lean muscle from a few injections! this is without resistance training and i think on women. but at 100$/mg thats 1000$ per injection. anyway i have heard (anecdotally) of super low dosing creating unbelievable pumps and muscle hardness that remains 6 months after stopping. so im gonna give a couple 100 mcgs per day a try. ive got a mg of igf1-lr3 also. and ghrp/cjc-1295 stack seems like a good way to heal up some injuries so maybe that for after im of the aas. i will keep yall posted on the progress. im currently 212 lbs at 12% bf

[MickeyKnox]

great write up and break down Blergs! thanks for posting that!

[BigBadWolf]

What do you think about gw-501516?

[ironbeck]

I hear its awesome for energy....

[Muscletech]

It's a fat loss compound..

GW-501516 (also known as GW-501,516,GW1516 or GSK-516) is a PPAR***948; modulator compound being investigated for drug use by GlaxoSmithKline.[1][2] It activates the same pathways activated through exercise, including PPAR***948; and AMP-activated protein kinase. It is being investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease. [3] [4] GW-501516 has a synergistic effect when combined with AICAR: the combination has been shown to significantly increase exercise endurance in animal studies more than either compound alone. [5][6]
GW-50156 regulates fat burning through a number of widespread mechanisms [7]; it increases glucose uptake in skeletal muscle tissue and increases muscle gene expression, especially genes involved in preferential lipid utilization.,[8][9] [10] This shift changes the body's metabolism to favor burning fat for energy instead of carbohydrates or muscle protein, potentially allowing clinical application for obese patients to lose fat effectively without experiencing muscle catabolism or the effects and satiety issues associated with low blood sugar. [11] GW-501516 also increases muscle mass, which improved glucose tolerance and reduced fat mass accumulation even in mice fed a very high fat diet, suggesting that GW-501516 may have a protective effect against obesity [12]

It has been demonstrated at oral doses of 5 mg a day to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome, most likely by stimulating fatty acid oxidation.[13] Treatments with GW-501516 have been shown to increase HDL cholesterol by up to 79% in rhesus monkeys and the compound is now undergoing Phase II trials to improve HDL cholesterol in humans. [14]

Concerns were raised prior to the 2008 Beijing Olympics that GW-501516 could be used by athletes as a performance enhancing drug which was not currently controlled by regulations or detected by standard tests. One of the main researchers from the study on enhanced endurance consequently developed a urine test to detect the drug, and made it available to the International Olympic Committee.[15] The World Anti-Doping Agency has also begun work on a test GW-501516 and other related PPAR***948; modulators.,[16] and they have been added to the prohibited list from 2009 onwards.[17] The compound has yet to be named a controlled or prohibited substance by any nation's drug enforcement or regulation agency. To date, no athlete is known to have tested positive for the substance, though the increase in endurance, muscle fiber performance, fat loss and metabolism suggests GW-501516 has the potential for ergogenic use and abuse.
GW-501516 (also known as GW-501,516,GW1516 or GSK-516) is a PPAR***948; modulator compound being investigated for drug use by GlaxoSmithKline.[1][2] It activates the same pathways activated through exercise, including PPAR***948; and AMP-activated protein kinase. It is being investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease. [3] [4] GW-501516 has a synergistic effect when combined with AICAR: the combination has been shown to significantly increase exercise endurance in animal studies more than either compound alone. [5][6]
GW-50156 regulates fat burning through a number of widespread mechanisms [7]; it increases glucose uptake in skeletal muscle tissue and increases muscle gene expression, especially genes involved in preferential lipid utilization.,[8][9] [10] This shift changes the body's metabolism to favor burning fat for energy instead of carbohydrates or muscle protein, potentially allowing clinical application for obese patients to lose fat effectively without experiencing muscle catabolism or the effects and satiety issues associated with low blood sugar. [11] GW-501516 also increases muscle mass, which improved glucose tolerance and reduced fat mass accumulation even in mice fed a very high fat diet, suggesting that GW-501516 may have a protective effect against obesity [12]

It has been demonstrated at oral doses of 5 mg a day to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome, most likely by stimulating fatty acid oxidation.[13] Treatments with GW-501516 have been shown to increase HDL cholesterol by up to 79% in rhesus monkeys and the compound is now undergoing Phase II trials to improve HDL cholesterol in humans. [14]

Concerns were raised prior to the 2008 Beijing Olympics that GW-501516 could be used by athletes as a performance enhancing drug which was not currently controlled by regulations or detected by standard tests. One of the main researchers from the study on enhanced endurance consequently developed a urine test to detect the drug, and made it available to the International Olympic Committee.[15] The World Anti-Doping Agency has also begun work on a test GW-501516 and other related PPAR***948; modulators.,[16] and they have been added to the prohibited list from 2009 onwards.[17] The compound has yet to be named a controlled or prohibited substance by any nation's drug enforcement or regulation agency. To date, no athlete is known to have tested positive for the substance, though the increase in endurance, muscle fiber performance, fat loss and metabolism suggests GW-501516 has the potential for ergogenic use and abuse.

In 2008, researchers at the Salk Institute discovered that AICAR injected in experimental mice significantly improves their performance in endurance-type exercise, apparently by converting fast-twitch muscle fibers to the more energy-efficient, fat-burning, slow-twitch type. They also looked at the administration of GW 501516 (also called GW1516) in combination with AICAR. Given to mice that did not exercise, this combination activated 40% of the genes that were turned on when mice were given GW1516 and made to exercise. This suggests it may be possible to obtain some of the benefits of exercising without actually exercising.Because of the enhanced endurance effects, this could potentially be used by athletes to enhance their performance.
AICA ribonucleotide (AICAR) or 5-Aminoimidazole-4-carboxamide riboside acts as an AMP-activated protein kinase agonist. It stimulates glucose uptake and increases the activity of p38 mitogen-activated protein kinases α and β in skeletal muscle tissue,as well as suppressing apoptosis by reducing production of reactive oxygen compounds inside the cell.
In 2008, researchers at the Salk Institute discovered that AICAR injected in experimental mice significantly improves their performance in endurance-type exercise, apparently by converting fast-twitch muscle fibers to the more energy-efficient, fat-burning, slow-twitch type. They also looked at the administration of GW 501516 (also called GW1516) in combination with AICAR. Given to mice that did not exercise, this combination activated 40% of the genes that were turned on when mice were given GW1516 and made to exercise. This suggests it may be possible to obtain some of the benefits of exercising without actually exercising.Because of the enhanced endurance effects, this could potentially be used by athletes to enhance their performance. One of the lead researchers from this study has developed a urine test to detect it and has made the test available to the International Olympic Committee, and the World Anti-Doping Agency has added AICAR to the prohibited list from 2009 onwards.

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GW-501516 30ml-10mg/ml

GW-501516 (also known as GW-501,516, GW1516 or GSK-516) is a PPARδ modulator compound being investigated for drug use by GlaxoSmithKline. It activates the same pathways activated through exercise, including PPARδ and AMP-activated protein kinase. It is being investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease. GW-501516 has a synergistic effect when combined with AICAR: the combination has been shown to significantly increase exercise endurance in animal studies more than either compound alone.
GW-50156 regulates fat burning through a number of widespread mechanisms; it increases glucose uptake in skeletal muscle tissue and increases muscle gene expression, especially genes involved in preferential lipid utilization., This shift changes the body's metabolism to favor burning fat for energy instead of carbohydrates or muscle protein, potentially allowing clinical application for obese patients to lose fat effectively without experiencing muscle catabolism or the effects and satiety issues associated with low blood sugar. GW-501516 also increases muscle mass, which improved glucose tolerance and reduced fat mass accumulation even in mice fed a very high fat diet, suggesting that GW-501516 may have a protective effect against obesity
It has been demonstrated at oral doses of 5 mg a day to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome, most likely by stimulating fatty acid oxidation. Treatments with GW-501516 have been shown to increase HDL cholesterol by up to 79% in rhesus monkeys and the compound is now undergoing Phase II trials to improve HDL cholesterol in humans.
Concerns were raised prior to the 2008 Beijing Olympics that GW-501516 could be used by athletes as a performance enhancing drug which was not currently controlled by regulations or detected by standard tests. One of the main researchers from the study on enhanced endurance consequently developed a urine test to detect the drug, and made it available to the International Olympic Committee. The World Anti-Doping Agency has also begun work on a test GW-501516 and other related PPARδ modulators., and they have been added to the prohibited list from 2009 onwards. The compound has yet to be named a controlled or prohibited substance by any nation's drug enforcement or regulation agency. To date, no athlete is known to have tested positive for the substance, though the increase in endurance, muscle fiber performance, fat loss and metabolism suggests GW-501516 has the potential for ergogenic use and abuse.
Mice which can run almost twice the distance of normal mice have been genetically engineered by US scientists.
"This is the first animal engineered for increased endurance," says Ronald Evans of the Salk Institute in La Jolla, California, whose team created the mice.
But Evans adds that the work also suggests that drugs already in clinical development may, unintentionally, boost endurance. "The potential for this to be abused by athletes is real," he points out.
Pills that mimic the benefit of exercise could also help patients whose conditions prevent them from exercising and building muscle, such as people suffering from obesity. In fact, it was while studying genes involved in obesity and fat metabolism that Evans's team stumbled across how to make mice long distance runners.
The focus of their work was a protein called PPARdelta, known to play a role in promoting the burning of fat and fighting obesity.
In previous work, his team has shown that increasing the activity of PPARdelta in fat cells encourages cells to reduce their fat stores. In the body, however, the greatest consumer of fat is slow twitch muscle, the type of muscle that gives athletes endurance. The other major type of muscle is fast twitch which is powered mainly by sugar and is responsible for strength and rapid reaction.
Conditioned athletes

So Evans's team genetically-engineered mice to produce extra PPARdelta in their muscle. As expected, when these engineered mice and control mice were put on a high fat diet for 97 days, the engineered mice experience only one-third of the weight gain that controls did.
But to the researchers' surprise, increasing PPARdelta also had a dramatic effect on the muscle composition itself: it doubled the amount of slow twitch muscle.
"These mice are genetically in better shape. They behave like conditioned athletes," says Evans. When tested, the marathon mice were able to run 92 per cent longer than normal controls.
It is unclear whether boosting PPARdelta levels later in life - or in people - would similarly enhance endurance. But, by coincidence, a drug called GW501516 which activates PPARdelta directly - is being clinically tested as a treatment to lower blood cholesterol and fat by the pharmaceutical company GlaxoSmithKline.
Evans has already shown the new drug causes many of the same genetic changes in muscle cells triggered by increasing levels of PPARdelta protein.
Therapeutic purposes

The question that remains is whether the drug alone will be enough to increase endurance "I suspect that animals training with the drug will increase endurance more rapidly," predicts Evans.
Evans says he has no affiliation with GlaxoSmithKline. And the company has so far been able to provide any comment on the work.
Farnaz Khadem, a spokesperson for the World Anti-Doping Agency, which strives to make sporting competitions drug-free, says she would not be surprised if cheating athletes would try taking GW501516, if it becomes available.
"Most doping involves a substance developed for therapeutic purposes being used for a sports purpose," she says. "Medical science is moving forward, which is good. But it also means we've got to be on our toes."
Journal reference: Public Library of Science Biology (vol 2, e294)Ref: http://en.wikipedia.org/wiki/GW_501516

[Glastokid]

Hiya mate. ive been doing a lot of research about igf1 lr3 and sounds fantastic for what i want, gains,cardio,fat loss.
I want to run it for 40 to 50 days at 4ui a day going up to 6 to 8 depending on the outcome. Ive whittled it down to 2 suppliers from china at a cost of $95 for a kit. Ive asked for photos of the product and looks very good also ive had fed ex reports of proof of other clients getting thier package. am i allowed to post the supliers name so you could tell me if you or anybody you know has used them before. I understand about people being ripped off with kigtropin and that somebody has hacked gensci site and sellin duff stuff under their name. www.bodystrong.com WUYI DATIAN Biotech Co., Ltd is one i have chosen and the other is Yuzuan Technology & Biology Products Co., Ltd....Would be great if you cuold help

[toothache]

Great read, blergs!

[noon]

That's the best read I have found yet. thank you for your input