
Originally Posted by
Chuckdiesel
Hey brothers, I know this thread is little old, but after joining with datbtrue I have found a TON of useful information about peptides...here is some very useful info I found...it has a bit of info relating to peptide use and using it with and without food. Sorry if im not allowed to copy and paste and I will edit if need be, but the sharing of information is so useful and especially when peptides are lacking the credit they are trying to earn with how beneficial and useful they are, I must pass the word in im an extremely firm believer in the use of peptides
After a meal, somatotropes are temporarily refractory to growth hormone-releasing hormone (GHRH), the principal hormone that stimulates secretion of growth hormone (GH). Refractoriness is particularly evident when free access to feed is restricted to a 2-h period each day. GH-releasing peptide-6 (GHRP-6), a synthetic peptide, also stimulates secretion of GH from somatotropes. Because GHRH and GHRP-6 act via different receptors, we hypothesized that GHRP-6 would increase GHRH-induced secretion of GH after feeding. Initially, we determined that intravenous injection of GHRP-6 at 1, 3 and 10 ug/kg body weight (BW) stimulated secretion of GH in a dose-dependent manner.
Next, we determined that GHRP-6- and GHRH-induced secretion of GH was lower 1 h after feeding (22.5 and 20 ng/ml respectively) than 1 h before feeding (53.5 and 64.5 ng/ml respectively; pooled (S.E.M.=8.5).
However, a combination of GHRP-6 at 3 ug/kg BW and GHRH at 0.2 ug/kg BW synergistically induced an equal and massive release of GH before and after feeding that was fivefold greater than GHRH induced release of GH after feeding.