Page 1 of 2 12 LastLast
Results 1 to 40 of 50
  1. #1
    marcus300's Avatar
    marcus300 is offline AR-Platinum Elite- Hall of Famer
    Join Date
    Jan 2005
    Location
    ENGLAND
    Posts
    39,946

    Thyroid Hormone + Growth Hormone with James Daemon, Ph.D.

    Thyroid Hormone + Growth Hormone
    (If You Aren’t Using T4 with Your GH, You’re Not Doing It Right)

    --------------------------------------------------------------------------------
    with James Daemon, Ph.D.

    -----------------------------------------------------------


    Anabolic Steroid Books
    Anabolics 2006 by William Llewellyn - Regarded as the undisputed mother of all steroid reference manuals! Pro bodybuilders, world-class powerlifters, Olympic competitors, and professional athletes alike have relied on ANABOLICS for the better part of a decade.

    Anabolic Steroids : The Ultimate Research Guide by Steroid. com - This book isn’t another dry technical manual that will have you asking more questions than when you first starting reading it. It has been written in a straight forward and conversational style that you will understand

    Legal Muscle by Rick Collin - The ultimate anabolic steroid resource, covering all aspects of non-medical anabolic steroid use under American law. It's essential reading for natural and "juiced" athletes alike.

    Recent Articles
    Winstrol - Oral versus Injectable by Steroid.com (June 2006)

    Anabolic Steroid Induced Hypogonadism by Michael Scally, MD (April 2006)

    Designing an Anabolic Steroid Cycle by Steroid.com (March 2006)

    Should Nolvadex be Avoided at All Cost? by Dharkam (January 30, 2006)

    Masteron As An Anti-Estrogen by Steroid.com (January 23, 2006)

    Steroids and Red Blood Cells by William Llewellyn (January 3, 2006)

    Post Cycle Therapy (PCT) by Steroid.com (November 14, 2005)

    Testosterone for Women: Waiting for the Female Aphrodisiac by John Hoberman, PhD (August 14, 2005)

    Anabolic Steroids and Suicide: A Brief Review of the Evidence by Jack Darkes, PhD (July 19, 2005)

    Dopers in Uniform - Cops on Steroids by John Hoberman, PhD (May 22, 2005)

    Multimedia
    HBO Real Sports "Anabolic Steroids Can Be Used Safely..."

    Virtually everybody from sportswriters and talk-show hosts to league executives and U.S. Congressmen has weighed in on the subject of steroid use. In a tell-all book that made headlines this spring, former baseball star Jose Canseco wrote about the positive effects of steroids in reasonable doses. Was he right? Armen Keteyian, who has been reporting on illegal substances in sports for the past five years, investigates the belief held by some scientists that steroids, when properly administered, cause no harm in adults. Downloadable Video 44 MB




    Posted July 23, 2006. Originally published at http://www.*************.net)

    Discussion of pharmaceutical agents below is presented for information only. Nothing here is meant to take the place of advice from a licensed health care practitioner. Consult a physician before taking any medication.

    Quite some time ago, I wrote a book on Anabolics, and since then, I’ve received quite a bit of feedback on it. Some of the information contained in the book is based on the 50-60 profiles I completed for Steroid.com’s main page. As a result, I get feedback on certain portions of the book from people who have read them online.

    When someone takes the time to send an e-mail to Steroid.com or AnabolicBooks LLC, they’re screened, and eventually some of them make their way to my e-mail account. AnabolicBooks LLC is publisher- a little known fact is that my book is actually wasn’t edited by me, nor do I own the rights to any of it. When they forward an e-mail to me, I typically consider it very carefully, and reply to the original sender. If amendments or additions are useful for anything I’ve previously written (readers frequently send me recently published studies), I typically reply and thank the person for their help.

    This time, something odd happened. I was forwarded an e-mail from AnabolicBooks, and the reader seemed to know what he was talking about, but (I thought) mistaken about interactions between Growth Hormone and Thyroid medication. I took a look at the e-mail, and knew that I could quickly find a study that I had saved previously, to send to the reader, to verify that the claims in my work on GH were sound.

    In this particular case- James Daemon, PhD- was the reader, and was correct in his assessment of the interaction between thyroid hormone and Growth Hormone. And, in direct contradiction, so was I. Thyroid medication decreases the anabolic effect of Growth Hormone. And it increases it.

    Huh?

    There’re some leaps here, because research in some of the necessary areas is sketchy (or not done yet), but if you read the entirety of this article, you’ll learn how to get a significantly more gains from Growth Hormone, for pennies a day, by the addition of a readily available (and cheap) addition to it. And yeah, it’s a drug you can get anywhere on the ‘net, very easily. And no, it’s not a steroid.

    In fact, I’ll go so far as to say you’re throwing away a substantial portion of your gains from growth hormone if you are not using this drug with it.

    Ok…I’ll explain things a bit further. First, a brief explanation of Thyroid Hormone as well as Growth Hormone may be necessary.

    Your thyroid gland secretes two hormones that are going to be of primary importance in understanding Thyroid/GH interaction. The first is thyroxine (T4) and the second is triiodothyronine (T3). T3 is frequently considered the physiologically active hormone, and consequently the one on which most athletes and bodybuilders focus their energies on. T4, on the other hand, is converted in peripheral tissue into T3 by the enzymes in the deiodinase group, of which there are three types- the three iodothyronine deiodinase either catalyze the initiation (D1, D2) or termination (D3) of thyroid hormone effects. The majority of the body's T3 (about 80%) comes from this conversion via the first two types of deiodinase, while conversion to an inactive state is accomplished by the third type.

    It’s important to note that not all of the body’s T4 is converted to T3, however- some remains unconverted. The secretion of T4 is under the control of Thyroid Stimulating Hormone (TSH) which is produced by the pituitary gland. TSH secretion is in turn controlled through release of Thyrotropin Releasing Hormone which is produced in your hypothalamus. So, when T3 levels go up, TSH secretion is suppressed, due to the body’s self regulatory system known as the "negative feedback loop" . This is also the mechanism whereby exogenous thyroid hormone suppresses natural thyroid hormone production. However, it should be noted that thyroid stimulating hormone (like all other hormones) can not work in a vacuum. TSH also requires the presence of Insulin or Insulin-like Growth Factor to stimulate thyroid function (1) When thyroid hormone is present without either insulin or IGF-1, it has no physiological effect (ibid).

    Most people think that T3 is just a physiologically active hormone that regulates bodyfat setpoint and has some minor anabolic effects, but in actuality, in some cases of delayed growth in children, T3 is actually too low, while GH levels are normal, and this has a growth limiting effect on several tissues (2) This could be due to T3’s ability to stimulate the proliferation of IGF-1 mRNA in many tissues (which would, of course, be anabolic), or it could be due to the synergistic effect T3 has on GH, specifically on regulation of the growth hormone gene. Although it is largely overlooked in the world of performance enhan***ent, regulation of the growth hormone response is predominantly determined by positive control of growth hormone gene transcription which is proportional to the concentration of thyroid hormone-receptor complexes, which are influenced by T3 levels. (3)

    At this point, just to give you a better understanding of what’s going on, I think it’s prudent to also give a brief explanation of Growth Hormone (GH) as well.

    Your body’s GH is regulated by many internal factors, such as hormones and enzymes. hormones. A change in the level of your body’s GH output begins in the hypothalamus with somatostatin (SS) and growth hormone-releasing hormone (GHRH). Somatostatin exerts its effect at the pituitary to decrease GH output, while GHRH acts at the pituitary to increase GH output. Together these hormones regulate the level of GH you have in your body. In many cases, GH deficiency presents with a low level of T3, and normal T4(4). This is of course because conversion of T4-T3 is partially dependant on GH (and to some degree GH stimulated IGF-1), and it’s ability to stimulate that conversion process of T4 into T3.

    Interestingly, the hypothalamus isn’t the only place where SS is contained; the thyroid gland also contains Somatostatin-producing cells. This is of interest to us, because in the case of the thyroid, it’s been noted that certain hormones which were previously thought only to govern GH secretion can also influence thyroid hormone output as well. SS can directly act to inhibit TSH secretion or it may act on the hypothalamus to inhibit TRH secretion. So when you add GH into your body from an outside source, you are triggering the body into releasing SS, because your body no longer needs to produce its own supply of GH…and unfortunately, the release of SS can also inhibit TSH, and therefore limit the amount of T4 your body produces.

    But that’s not the only interaction we see between the thyroid and Growth Hormone.

    As we learned in high-school Biology class, the body likes to maintain homeostasis, or "normal" operating conditions. This is the body’s version of the status quo, and it fights like hell to maintain the comfort of the status quo (much like moderators on most steroid discussion boards). What we see with thyroid/GH interplay is that physiological levels of circulating thyroid hormones are necessary to maintain normal pituitary GH secretion, due to their directly stimulatory actions. However, when serum concentrations of thyroid hormone increase above the normal range we see an increase in hypothalamic somatostatin action, which suppresses pituitary GH secretion and overrides any stimulatory effects that the thyroid hormone may have had on GH. The suppression of GH secretion by thyroid hormones is probably mediated at the hypothalamic level by a decrease in GHRH release(5).

    In addition, as IGF-I production is increased in the hypothalamus after T3 administration and T3 may participate in IGF-1 mediated negative feedback of GH by triggering either increased somatostatin tone and/or decreased GHRH production (6). IGF, interestingly, has the ability to mediate some of T3’s effects independent of GH, but not to the same degree GH can (7.) In fact, IGF-I production is increased in the hypothalamus after T3, administration it may plausibly participate in negative feedback by triggering either increased somatostatin tone and/or decreased GHRH production. So we know that GH lowers T4 (more about this in a sec), but an increase in T3 upregulates GH receptors (8) as well as IGF-1 receptors (9,10).

    As can be previously stated, and due to the ability of GH to convert inactive T4 into active T3, GH administration in healthy athletes shows us an entirely predicatble increase in mean free T3 (fT3), and a decrease in mean free T4 (fT4) levels.(11)




    Interaction between GH, IGF-I, T3, and GC. GH stimulates hepatic IGF-I secretion and local production of growth plate IGF-I, and exerts direct actions in the growth plate. Circulating T3 is derived from the thyroid gland and by enzymatic deiodination of T4 in liver and kidne.. The regulatory 5'-DI and 11ßHSD type 2 enzymes may also be expressed in chondrocytes to control local supplies of intracellular T3 and GC. Receptors for each hormone (GHR, IGF-IR, TR, GR) are expressed in growth plate chondrocytes.

    So, with the use of GH, what we see is an increased conversion of T4-T3, and possible inhibition of Thyroid Releasing Hormone by Somatostatin, and therefore even though T3 levels may rise, there is no increase in T4 (logically, we see a decrease). Now, as we’ve seen, GH is HIGHLY synergistic with T3 in the body, and as a mater of fact, if you’ve been paying any attention up until this point, you’ll note that the limiting factor on GH’s ability to exert many of it’s effects, is mediated by the amount of T3 in the body.

    As noted before, T3 enhances many effects of GH by several mechanisms, including (but not limited to): increasing IGF-1 levels, IGF-1 mRNA levels, and finally by actually mediating the control of the growth hormone gene transcription process as seen below:


    Comparison of the kinetics of L-T3-receptor binding abundance to changes in the rate of transcription of the GH gene.(3)

    As you can see, T3 levels are directly correlative to GH gene transcription. The scientists who conducted the study which provided the graph above concluded that the amount of T3 present is a regulatory factor on how much GH gene transcription actually occurs. And gene transcription is what actually gives us the effects from GH. This last fact really seems to shed some light on why we need T3 levels to be supraphysiological if we’re going to be using supraphysiological levels of GH, right? Otherwise, the GH we’re using is going to be limited by the amount of T3 our body produces. However, since we’re taking GH, and it is converting more T4 into T3, T4 levels are lowered substantially, and this is the problem with GH. and may actually be THE limiting factor on GH…if we assume that at least some of GH’s effects are enhanced by thyroid hormone, and specifically T3, then what we are looking at is the GH that has been injected is being limited by a lack of T3. But that doesn’t make sense, because if we use T3 + GH, we get a decrease in the anabolic effect of GH.

    This is where Mr. Daemon, who had contacted me via an e-mail to my publisher, about Thyroid + GH interaction, was able to shed some light on things. You see, I knew that it couldn’t just be the actual presence of enough T3 along with the GH that was limiting GH’s anabolic effect, because, simply adding T3 to a GH cycle will reduce the anabolic effect of the GH (12.).

    Originally, he had said to me that T3 was synergistic with GH, wheras I said that T3 actually reduced the anabolic effects of GH- now I realize we were both correct. Logically this presents a bit of a problem, which I believe can be solved. This came from reading several studies provided to me by Dr.Daemon. the trend I was seeing was that even when Growth Hormone therapy was used, T3 levels needed to be elevated in order to treat several conditions caused by a lack of natural growth hormone. And even if the patient was on GH, T3 levels still needed to be elevated. And what I noticed was that those levels were elevated successfully by using supplemental T4 but not T3.

    Here’s why I think this is:

    Additional T3 is not all that’s needed here. What’s needed is the actual conversion process of T4-T3, and the deiodinase presence and activity that it involves. This is because Local 5'-deiodination of l-thyroxine (T4) to active the thyroid hormone 3,3',5-tri-iodothyronine (T3) is catalyzed by the two 5'-deiodinase enzymes (D1 and D2). These enzymes not only "create" T3 out of T4, but actually regulates various T(3)-dependent functions in many tissues including the anterior pituitary and liver. So when there is an excess of T3 in the body, but normal levels of T4, the body’s thyroid axis sends a negative feedback signal., and produces less (D1 and D2) deiodinase, but more of the D3 type, which signals the cessation of the T4-T3 conversion process, and is inhibitory of many of the synergistic effects that T3 has! Remember, Type 3 iodothyronine deiodinase (D3) is the physiologic INACTIVATOR of thyroid hormones and their effects (13) and is well known to have independent interaction with growth factors (which is what GH and IGF-1 are).(14) This is because with adequate T4 and excess T3, (D1 and D2) deiodinase is no longer needed for conversion of T4 into T3, but levels of D3 deiodinase will be elevated. When there is less of the first two types of deidinase, it would seem that the T3 which has been converted to T4 can not exert it’s protein sparing (anabolic effects), as those first two types are responsible for mediation of many of the effects T3 has on the body. This seems to be one of the ways deiodinase contributes to anabolism in the presence of other hormones.

    All of this would explain why anecdotally we see bodybuilders who use T3 lose a lot of muscle if they aren’t using anabolics along with it- they’re not utilizing the enzyme that would regulate some of T3’s ability to stimulate protein synthesis, while they are simultaneously signaling the body to produce an inhibitory enzyme (D3). And remember, for decades bodybuilders who were dieting for a contest have been convinced that you lose less muscle with T4 use, but that it’s less effective for losing fat when compared with T3? Well, as we’ve seen, without something (GH in this case) to aid in the conversion process, it would clearly be less effective! Since the deiodinase enzyme is also located in the liver, and we see decreased hepatic nitrogen clearance with GH + T3, it would seem that the D3 enzyme is exerting it’s inhibitory effects, but in the absence of the effects of the first two deiodinase enzymes, it remains unchecked and therefore not only limits the GH’s nitrogen retention capability.

    In other words, if we have enough to GH in our body aid in supraphysiological conversion of T4 into T3, but we already have the too much (exogenous) T3, the GH is not going to be converting any excess T4 into T3 after a certain point- which would be a limiting factor in GH’s anabolic effects, when coupled with the act that we’ve allowed the D3 enzyme to inhibit the T3/GH synergy that is necessary.

    As further evidence, when we look at certain types of cellular growth (the cartilage cell in this case) we see that GH induced rises in IGF-I stimulates proliferation, whereas T3 is responsible for hypertrophic differentiation. So it would seem that in some tissues, IGF-1 stimulates the synthesis of new cells, while T3 makes them larger. In this particular case, The fact that T4 and (D1) deiodinase is am active component in this system is noted by the authors. They clearly state (paraphrasing) that: "T4 is is converted to T3 by deiodinase (5'-DI type 1) in peripheral tissues…[furthermore]GH stimulates conversion of T4 to T3 , suggesting that some effects of GH may involve this pathway." The thing I want you to notice is that the authors of this paper state that the that the conversion PATHWAY is probably involved, and not the simple presence of T3. (15 )

    Also, that same study notes that T3 has the ability to stimulates IGF-I and expression in tissues that whereas GH has no such effect (ibid).

    So what are we doing when we add T3 to GH? We’re effectively shutting down the conversion pathway that is responsible for some of GH’s effects! And what would we be doing if we added in T4 instead of T3? You got it- we’d be enhancing the pathway by allowing the GH we’re using to have more T4 to convert to T3, thus giving us more of an effect from the GH we’re taking. Adding T4 into our GH cycles will actually allow more of the GH to be used effectively!

    Remember, the thing that catalyzes the conversion process is the deiodinase enzyme. This is also why using low amounts of T3 would seem (again, anecdotally in bodybuilders) to be able to slightly increase protein synthesis and have an anabolic effect – they aren’t using enough to tell the body to stop or slow down production of the deiodinase enzyme, and hence .Although this analogy isn’t perfect, think of GH as a supercharger you have attached to your car…if you don’t provide enough fuel for it to burn at it’s increased output level, you aren’t going to derive the full effects. Thyroid status also may influence IGF-I expression in tissues other than the liver.So what we have here is a problem. When we take GH, it lowers T3 levels…but we need T3 to keep our GH receptor levels optimally upregulated. In addition, it’s suspected that many of GH’s anabolic effects are engendered as a result of production of IGF-1, so keeping our IGF receptors upregulated by maintaining adequate levels of T3 seems prudent. But as we’ve just seen, supplementing T3 with our GH will abolish Growth Hormone’s functional hepatic nitrogen clearance, possibly through the effect of reducing the bioavailability of insulin-like growth factor-I (12.)

    So we want elevated T3 levels when we take GH, or we won’t be getting ANYWHERE NEAR the full anabolic effect of our injectable GH without enough T3. And now we know that not only do we need the additional T3, but we actually want the CONVERSION process of T4 into T3 to take place, because it’s the presence of those mediator enzymes that will allow the T3 to be synergistic with GH, instead of being inhibitory as is seen when T3 is simply added to a GH cycle. And remember, we don’t only want T3 levels high, but we want types 1 and 2 deiodinase to get us there- and when we take supplemental T3, that just doesn’t happen…all that happens is the type 3 deiodinase enzyme shows up and negates the beneficial effects of the T3 when we combine it with GH.

    And that’s where myself and Dr. Daemon ended up, after a week of e-mails, researching studies, and gathering clues.

    If you’ve been using GH without T4, you’ve been wasting half your money – and if you’ve been using it with T3, you’ve been wasting your time. Start using T4 with your GH, and you’ll finally be getting the full results from your investment.

    References:

    Growth Factors. 1990;2(2-3):99-109.Interaction of TSH, insulin and insulin-like growth factors in regulating thyroid growth and function. Eggo MC, Bachrach LK, Burrow GN.

    F, Rumpler M, Klaushofer K 1994 Thyroid hormones increase insulin-like growth factor mRNA levels in the clonal osteoblastic cell line MC3T3- E1. FEBS Lett 345: 67–70

    Relationship of the rate of transcription to the level of nuclear thyroid hormone-receptor complexes.J Biol Chem. 1984 May 25;259(10):6284-91. Yaffe BM, Samuels HH.

    Thyroid morphology and function in adults with untreated isolated growth hormone deficiency. J Clin Endocrinol Metab. 2006 Mar;91(3):860-4. Epub 2006 Jan 4.

    Eur J Endocrinol.1995 Dec;133(6):646-53.Influence of thyroid hormones on the regulation of growth hormone secretion. Giustina A, Wehrenberg WB.

    Binoux M, Faivre-Bauman A, Lassarre C, Tixier-Vidal A 1985 Triiodothyronine stimulates the production of insulin-like growth factor I (IGF-I) by fetal hypothalamus cells cultured in serum free medium. Dev Brain Res 21:319–323

    Eur J Endocrinol. 1996 May;134(5):563-7.Insulin-like growth factor I alters peripheral thyroid hormone metabolism in humans: comparison with growth hormone.Hussain MA, Schmitz O, Jorgensen JO, Christiansen JS, Weeke J, Schmid C, Froesch ER

    Harakawa S, Yamashita S, Tobinaga T, Matsuo K, Hirayu H, Izumi M, Nagataki S, Melmed S. In vivo regulation of hepatic insulin-like growth factor-1 messenger ribonucleic acids with thyroid hormone. Endocrinol Jpn 37(2):205-11, 1990

    Hochberg Z, Bick T, Harel Z Alterations of human growth hormone binding by rat liver membranes during hypo- and hyperthyroidism. Endocrinology 126(1):325-9, 1990

    Matsuo K, Yamashita S, Niwa M, Kurihara M, Harakawa S, Izumi M, Nagataki S, Melmed S Thyroid hormone regulates rat pituitary insulin-like growth factor-I receptors. Endocrinology 126(1):550-4, 1990

    The Journal of Clinical Endocrinology & Metabolism Vol. 88, No. 11 5221-5226, 2003. High Dose Growth Hormone Exerts an Anabolic Effect at Rest and during Exercise in Endurance-Trained Athletes M. L. Healy, J. Gibney, D. L. Russell-Jones, C. Pentecost, P. Croos, P. H. Sönksen and A. M. Umpleby

    J Hepatol. 1996 Mar;24(3):313-9. Effects of long-term growth hormone (GH) and triiodothyronine (T3) administration on functional hepatic nitrogen clearance in normal man.Wolthers T, Grofte T, Moller N, Vilstrup H, Jorgensen JO

    Huang, SA. Physiology and pathophysiology of type 3 deiodinase in humans. Thyroid. 2005 Aug;15(8):875-81. Review.

    Hernandez. A. Structure and function of the type 3 deiodinase gene.Thyroid. 2005 Aug;15(8):865-74. Review.

    F, Rumpler M, Klaushofer K 1994 Thyroid hormones increase insulin-like growth factor mRNA levels in the clonal osteoblastic cell line MC3T3- E1. FEBS Lett 345: 67–70


    any commets on this recent article
    *Anyone wanting a source check from a willing vet/mod must first acquire 100 posts and 45 days of activity*

    “Carrying a set to a point where you are forced to utilize 100 percent of your momentary ability is the single most important factor in increasing size and strength"--- Mike Mentzer

    “one set to failure is all that is required to stimulate an increase in strength and size – with no number of lesser sets having the same effect” – Mike Mentzer

  2. #2
    100%NATURAL-theGH's Avatar
    100%NATURAL-theGH is offline Senior Member
    Join Date
    Nov 2003
    Location
    City of Angels
    Posts
    1,622
    Interesting read... I'm sure I've read some stuff on it before but my research into GH is relatively new... luckily I just got some Synthroid ... 125mcg tablets... so would one a day be sufficient??? I think it should be.. and better than nothing... what would the optimal dose be assuming we believe this article..???

  3. #3
    Dilanger is offline New Member
    Join Date
    Feb 2005
    Location
    NY
    Posts
    44
    Great read Marcus. I'm sure you use t4 along with your GH. At what dose do you use t4?

  4. #4
    Join Date
    Sep 2005
    Posts
    3,902
    Quote Originally Posted by Dilanger
    Great read Marcus. I'm sure you use t4 along with your GH. At what dose do you use t4?
    T4 is best used between 50 and 100mcg ed with HGH

  5. #5
    Dilanger is offline New Member
    Join Date
    Feb 2005
    Location
    NY
    Posts
    44
    Thanks xtralarg, one more question. Do you cycle on and off the t4 during your HGH cycle? Or do you run t4 during the entire time on GH?

  6. #6
    100%NATURAL-theGH's Avatar
    100%NATURAL-theGH is offline Senior Member
    Join Date
    Nov 2003
    Location
    City of Angels
    Posts
    1,622
    between 50 and 100mcg? There's a good deal of difference between the two.. and dose your dose of GH play any factor in how much should be taken? and also like Dilanger asked... do you have to cycle it? (i'll use mine consistantly)

  7. #7
    Join Date
    Sep 2005
    Posts
    3,902
    Quote Originally Posted by Dilanger
    Thanks xtralarg, one more question. Do you cycle on and off the t4 during your HGH cycle? Or do you run t4 during the entire time on GH?
    No i dont cycle it,stay on it.

  8. #8
    Join Date
    Sep 2005
    Posts
    3,902
    Quote Originally Posted by 100%NATURAL-theGH
    between 50 and 100mcg? There's a good deal of difference between the two.. and dose your dose of GH play any factor in how much should be taken? and also like Dilanger asked... do you have to cycle it? (i'll use mine consistantly)
    Remember its T4 we are talkin about not T3, its like the difference between 12.5mcg and 25mcg of T3, not a massive deal really. No matter what dose I run I keep the dose the same(I now run 10iu 5/2). As answered above, no i dont cycle it.

  9. #9
    eisenmench is offline Junior Member
    Join Date
    May 2006
    Location
    Delaware
    Posts
    67
    Do you use T4 5/2 as well as the HGH?

  10. #10
    Join Date
    Sep 2005
    Posts
    3,902
    Quote Originally Posted by eisenmench
    Do you use T4 5/2 as well as the HGH?
    No, I use it ed.

  11. #11
    100%NATURAL-theGH's Avatar
    100%NATURAL-theGH is offline Senior Member
    Join Date
    Nov 2003
    Location
    City of Angels
    Posts
    1,622
    I say good deal of difference because I think there is probably a right amount to be taken... the more GH the more thyroid I would guess... maybe I'm wrong but if I had to go with a hunch that's what it would be.... I'm doing 5IU/ED... do you really think it's necessary to take the weekends off??? I train 6 days a week... so I like to use it ED...

  12. #12
    veryveryquiet's Avatar
    veryveryquiet is offline Junior Member
    Join Date
    Jun 2006
    Location
    Earth
    Posts
    132
    Interesting read, thanks Marcus

  13. #13
    comradebillyboy's Avatar
    comradebillyboy is offline Associate Member
    Join Date
    Jul 2006
    Location
    albuquerque, nm
    Posts
    294
    Quote Originally Posted by xtralarg
    No i dont cycle it,stay on it.
    Are you concerned about possible negative effects on your natural thyroid production? I am under the impression that one's thyroid may adjust to the exogenous T4 over time and reduce its natural output.

  14. #14
    Seattle Junk's Avatar
    Seattle Junk is offline Anabolic Member
    Join Date
    Jun 2005
    Location
    Sea-town (upper left USA)
    Posts
    3,010
    I'm using 200mcgs ed T4 with 3.3ius ed jintropin. Remember that t4 converts into T3 at a ratio of 4:1. So theoretically 200mcgs T4 converts into 50mcgs T3 in the body.

  15. #15
    Seattle Junk's Avatar
    Seattle Junk is offline Anabolic Member
    Join Date
    Jun 2005
    Location
    Sea-town (upper left USA)
    Posts
    3,010
    Quote Originally Posted by comradebillyboy
    Are you concerned about possible negative effects on your natural thyroid production? I am under the impression that one's thyroid may adjust to the exogenous T4 over time and reduce its natural output.
    t3 is decreased by GH and most AAS during a cycle. You are basically replacing your decreased levels back to normal t3 levels or a little bit higher. Protein synthesis is key, not necessarily fat loss. But fat loss is a great benefit of course.

  16. #16
    Seattle Junk's Avatar
    Seattle Junk is offline Anabolic Member
    Join Date
    Jun 2005
    Location
    Sea-town (upper left USA)
    Posts
    3,010
    Quote Originally Posted by xtralarg
    Remember its T4 we are talkin about not T3, its like the difference between 12.5mcg and 25mcg of T3, not a massive deal really. No matter what dose I run I keep the dose the same(I now run 10iu 5/2). As answered above, no i dont cycle it.
    Actually I've read and researched t4 converts to t3 at a ratio of 4:1, so 50mcgs t4 = 12.5mcgs t3 after conversion in the body.

  17. #17
    Join Date
    Sep 2005
    Posts
    3,902
    Quote Originally Posted by Seattle Junk
    Actually I've read and researched t4 converts to t3 at a ratio of 4:1, so 50mcgs t4 = 12.5mcgs t3 after conversion in the body.
    Actually thats what I stated.The difference between 50 and 100mcg of T4 is equivelant to 12.5-25mcg of T3.

    12.5(t3) x 4 = 50(t4)
    25(t3) x 4 = 100(t4)

    Hope this helps.

  18. #18
    Seattle Junk's Avatar
    Seattle Junk is offline Anabolic Member
    Join Date
    Jun 2005
    Location
    Sea-town (upper left USA)
    Posts
    3,010
    Quote Originally Posted by xtralarg
    Actually thats what I stated.The difference between 50 and 100mcg of T4 is equivelant to 12.5-25mcg of T3.

    12.5(t3) x 4 = 50(t4)
    25(t3) x 4 = 100(t4)

    Hope this helps.

    Sorry bro, I misunderstood. You are right.

  19. #19
    Join Date
    Sep 2005
    Posts
    3,902
    Quote Originally Posted by Seattle Junk
    Sorry bro, I misunderstood. You are right.
    No probs.Peace.

  20. #20
    Seattle Junk's Avatar
    Seattle Junk is offline Anabolic Member
    Join Date
    Jun 2005
    Location
    Sea-town (upper left USA)
    Posts
    3,010
    Amen Marcus, thank you. I read up on this a few months ago and I started t4 with my GH at that time. I'll have to say I'm getting great results. I haven't benched for over a month since I do mostly dumbells. Pressed 365lbs 3 times and it felt solid. No soarness in my joints or tendons like pre GH. Good stuff.

  21. #21
    Seattle Junk's Avatar
    Seattle Junk is offline Anabolic Member
    Join Date
    Jun 2005
    Location
    Sea-town (upper left USA)
    Posts
    3,010
    Quote Originally Posted by xtralarg
    Actually thats what I stated.The difference between 50 and 100mcg of T4 is equivelant to 12.5-25mcg of T3.

    12.5(t3) x 4 = 50(t4)
    25(t3) x 4 = 100(t4)

    Hope this helps.
    Technically that's not possible because t3 doesn't convert back into t4. Just reverse your conversions above.

    50(t4) X 4 = 12.5(t3)
    100(t4) X4 = 25(t3)

  22. #22
    eisenmench is offline Junior Member
    Join Date
    May 2006
    Location
    Delaware
    Posts
    67
    How long is 1/2 life of extra T4 in the body. Should HGH and T4 be taken together to be effective?

  23. #23
    doublefister is offline Associate Member
    Join Date
    Jan 2006
    Posts
    213
    Are there any references of any kind that state that the ratio of T4 to T3 is 4:1?

  24. #24
    pscarb's Avatar
    pscarb is offline Junior Member
    Join Date
    Apr 2006
    Posts
    124
    i believe the half life of T4 is 24 hrs for T3 it is 12hrs...

  25. #25
    goldenFloyd's Avatar
    goldenFloyd is offline Member
    Join Date
    Feb 2002
    Posts
    519
    Quote Originally Posted by Seattle Junk
    Technically that's not possible because t3 doesn't convert back into t4. Just reverse your conversions above.

    50(t4) X 4 = 12.5(t3)
    100(t4) X4 = 25(t3)
    well, if you want to be picky, you'd have to reverse the x to a / above as well

  26. #26
    WEBB's Avatar
    WEBB is offline AR-Hall of Famer
    Join Date
    Sep 2005
    Location
    Learnin from the best...
    Posts
    11,648
    what about using a T3/T4 combo...i am going to add T4 for sure, but i can get a 40mcgT3/100mcgT4 combo and was wondering if adding that will be a good idea, or if i should just stick with 100mcg T4 ed...any help is appreciated..

    WEBB

  27. #27
    eisenmench is offline Junior Member
    Join Date
    May 2006
    Location
    Delaware
    Posts
    67

    HGH-T4 & anti-aging

    Quote Originally Posted by WEBB
    what about using a T3/T4 combo...i am going to add T4 for sure, but i can get a 40mcgT3/100mcgT4 combo and was wondering if adding that will be a good idea, or if i should just stick with 100mcg T4 ed...any help is appreciated..

    WEBB
    I'm jumping in here to add a ?. Can T4 be used continuously (ED) along with HGH (12 months a year) in a HRT regimen? at 50-100mcg?

    Thanks webb

  28. #28
    Pensilneck is offline Associate Member
    Join Date
    Mar 2005
    Posts
    303
    Quote Originally Posted by eisenmench
    I'm jumping in here to add a ?. Can T4 be used continuously (ED) along with HGH (12 months a year) in a HRT regimen? at 50-100mcg?

    Thanks webb
    Thats what I wan`t to know too and second thing, can slin be used continuously with 6months... I`m run it now like this... HGH 4iu/ed 5on 2off + T4 100mcg/ed 5on 2off+ slin 10iu/ed 5on 2off. I`m now cycle T4 and slin 5weeks on 3weeks of. When I`m off with slin and T4 I use guggulsterons and efedrin to make my own thyroid production started.... I really don´t wan`t to get diabetes or ruin my thyroid gland.....
    Is my vigilance pointless?
    Last edited by Pensilneck; 01-15-2007 at 02:36 PM.

  29. #29
    comradebillyboy's Avatar
    comradebillyboy is offline Associate Member
    Join Date
    Jul 2006
    Location
    albuquerque, nm
    Posts
    294
    Quote Originally Posted by kobiack
    enough about where to get T4... where can you get some HGH?!
    The stuff is advertised openly on many of the open source BB boards. Check them out. Try a google search. Its not hard to find.

  30. #30
    Fixr is offline Associate Member
    Join Date
    Mar 2007
    Posts
    338
    this was a great read. thank you Marcus.

  31. #31
    gotjuice28's Avatar
    gotjuice28 is offline Banned
    Join Date
    Dec 2006
    Posts
    86
    huhm this was a great read.

  32. #32
    Join Date
    Nov 2007
    Posts
    527
    Quote Originally Posted by pscarb View Post
    i believe the half life of T4 is 24 hrs for T3 it is 12hrs...
    T4 half life is 5-7 days, whereas

    T3's half life is only about 1 day.

  33. #33
    stelq61th is offline New Member
    Join Date
    Jul 2009
    Posts
    15
    can you please post any T4 supplements prefer pharmaceutical grade ones, is L-Thyroxine suitable? I need the name of the one that I can run simultaneously with HGH on a HGH therapy, thank you

  34. #34
    midnight777's Avatar
    midnight777 is offline Associate Member
    Join Date
    May 2007
    Posts
    396
    going to start 100mcg of T4 along with my hgh.. when is the best time to take my T4. I am taking 4 iu's of hgh right now @ 4:45 am.. I am planning on going up to 6 iu's in the next few months. so I guess taking T4 is my best bet besides aas to get the most out of my hgh.... what sides should I look for in T4. thanks

  35. #35
    BJJ's Avatar
    BJJ
    BJJ is offline Sapiens Fingit Fortunam Sibi
    Join Date
    Aug 2009
    Location
    Catacombs
    Posts
    5,430
    I am going tomorrow morning, after a month of somatropin, to check my thyroid levels.
    Curious to see the results.

    Ready to implement with T4.

  36. #36
    Join Date
    Sep 2005
    Posts
    3,902
    Quote Originally Posted by BJJ View Post
    I am going tomorrow morning, after a month of somatropin, to check my thyroid levels.
    Curious to see the results.

    Ready to implement with T4.
    Any thyroid results?
    -XL

    jing jai

  37. #37
    BJJ's Avatar
    BJJ
    BJJ is offline Sapiens Fingit Fortunam Sibi
    Join Date
    Aug 2009
    Location
    Catacombs
    Posts
    5,430
    Quote Originally Posted by Xtralarg View Post
    Any thyroid results?
    A few days more, I need to wait...

  38. #38
    Join Date
    Sep 2005
    Posts
    3,902
    Quote Originally Posted by BJJ View Post
    A few days more, I need to wait...
    Ok...keep us informed...
    -XL

    jing jai

  39. #39
    BJJ's Avatar
    BJJ
    BJJ is offline Sapiens Fingit Fortunam Sibi
    Join Date
    Aug 2009
    Location
    Catacombs
    Posts
    5,430
    Quote Originally Posted by Xtralarg View Post
    Ok...keep us informed...
    I will, as usual.

  40. #40
    BJJ's Avatar
    BJJ
    BJJ is offline Sapiens Fingit Fortunam Sibi
    Join Date
    Aug 2009
    Location
    Catacombs
    Posts
    5,430
    http://forums.steroid.com/showthread.php?t=434351

    After a month of HGH without T4 support.

Page 1 of 2 12 LastLast

Thread Information

Users Browsing this Thread

There are currently 1 users browsing this thread. (0 members and 1 guests)

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •