Spot Pinning

**MILKMAN73** · 11-26-2020, 09:19 PM

Looking into TB500 and BCP157 for some joint injuries. So is spot pinning the way to go or bunk?

I've searched and find 100 answers both way. I wouldn't ask, but have more than one joint I wish to address. If it were just one, I'd just spot pin and not worry about it.

Old man problems.

**DustMan** · 11-27-2020, 04:29 AM

I'm also looking into both compounds right now, also very interested in the answer. The biggest question to me is, is the oral version viable or not? It would get processed by the liver before it gets distributed to the rest of the body, it's possible it doesn't stay in tact. The same argument can be made for non spot injection: Once absorbed into the body it's probably going to get metabolized to some degree before reaching the area you want to treat...

Still researching it myself, looking forward to any information anyone has.

**kelkel** · 11-27-2020, 10:39 AM

Originally Posted by DustMan

I'm also looking into both compounds right now, also very interested in the answer. The biggest question to me is, is the oral version viable or not? It would get processed by the liver before it gets distributed to the rest of the body, it's possible it doesn't stay in tact. The same argument can be made for non spot injection: Once absorbed into the body it's probably going to get metabolized to some degree before reaching the area you want to treat...

Still researching it myself, looking forward to any information anyone has.

Anecdotally localized injections are recommended however I too struggle to see the relevance. That said, how can it hurt? Read the last sentence of the abstract in the link below:

https://pubmed.ncbi.nlm.nih.gov/9403790/

**DustMan** · 11-27-2020, 11:37 AM

Originally Posted by kelkel

Anecdotally localized injections are recommended however I too struggle to see the relevance. That said, how can it hurt? Read the last sentence of the abstract in the link below:

https://pubmed.ncbi.nlm.nih.gov/9403790/

Wow, I used Sci Hub to get access to the full study, it looks very effective. I'm gonna have to try and vet a European dealer. You've always got the best links Kelkel!

**tarmyg** · 11-27-2020, 11:43 AM

Originally Posted by DustMan

Wow, I used Sci Hub to get access to the full study, it looks very effective. I'm gonna have to try and vet a European dealer. You've always got the best links Kelkel!

Inside the EU borders you can find this made by some high quality people as it’s not even remotely illegal.

Great read Kel, just reading up on this to try it on my shoulder.

**kelkel** · 11-27-2020, 11:49 AM

Originally Posted by tarmyg

Inside the EU borders you can find this made by some high quality people as it’s not even remotely illegal.

Great read Kel, just reading up on this to try it on my shoulder.

Using it for mine as we speak.

**tarmyg** · 11-27-2020, 11:50 AM

Originally Posted by kelkel

Using it for mine as we speak.

I noticed Ben Greenfield recommended 10mcg per kg of body weight for 2-weeks. You agree with that?

**tarmyg** · 11-27-2020, 01:14 PM

Originally Posted by Cylon357

I have found spot spinning these peps to be of negligible benefit. But they don't exactly have a kick, so it is kind of hard to tell. It likely doesn't hurt but I wouldn't expect an earth shattering difference.

As for dosing, I have found 1mg TB-500 and 400'ish mcg BPC-157 to be a good dose. Thymosin Labs used to have a 7/3 blend that seems to work well for that dosing, but they don't seem to have any injectables right now.

You take the bpc 2t/day and tb500 2t/week?

**MILKMAN73** · 11-27-2020, 01:22 PM

Originally Posted by kelkel

That said, how can it hurt?

My only concerns/thoughts were that I want to try it in both knees and both shoulders.

So I could A) take it once and it works on all joints at once or B) take it four times over, spot pinning each joint individually.

I'm leaning towards B. But like anything else, using too much of any one compound is always a real concern.

I get blood work done on the regular both through my primary care doc and now through my TRT clinic. So I feel I'm safe there. I'm near 50 with a wife and 3 kids, so I'm well beyond my foolish years of just putting anything into my body without any concern.

I'm thinking I'll focus on one joint at a time, spot pinning. However long treatment is I'm thinking take the same amount of time off before beginning the next joint, and repeat for each knee & shoulder. Then report back here with results.

I have stem cell treatments pending. I'm thinking about doing this BEFORE the stem cell treatments. Stem cells are pretty awesome, but they need some proper soft tissue to start with. Thinking this may help jump start things and give the stem cells a better fighting chance.

Open to input.

**kelkel** · 11-27-2020, 02:28 PM

I'd just sub-Q it as opposed to both knees.

**kelkel** · 11-27-2020, 02:30 PM

Originally Posted by tarmyg

I noticed Ben Greenfield recommended 10mcg per kg of body weight for 2-weeks. You agree with that?

Coin toss. Personally I stick with 500 mcg.

**DustMan** · 11-27-2020, 03:04 PM

Originally Posted by kelkel

Coin toss. Personally I stick with 500 mcg.

In that study you linked, the graphs show that, for the rats at least, 50mcg had barely any more affect than 10mcg, and 10mcg had barely any more affect than 10 nanogram's, meaning that the benefit seems mostly to be due to the presence of the compound, and that there are extremely steep diminishing returns. There isn't any data to find in humans, but the highest dose any human trial has used is 10mcg/kg of bodyweight, which looks like overkill to me.

Do you use the other compound as well? TB-500? Do you have a go to administration protocol for that?

**MILKMAN73** · 11-27-2020, 05:08 PM

Originally Posted by kelkel

I'd just sub-Q it as opposed to both knees.

Yeah I was thinking about squirting it down into the joints a bit. Maybe I should just stick to sub-Q. Idk I was just thinking get it into the target area couldn't hurt, but guess if it could.

Plan to do plenty more research beforehand. New compounds to me.

**kelkel** · 11-27-2020, 05:29 PM

Originally Posted by DustMan

In that study you linked, the graphs show that, for the rats at least, 50mcg had barely any more affect than 10mcg, and 10mcg had barely any more affect than 10 nanogram's, meaning that the benefit seems mostly to be due to the presence of the compound, and that there are extremely steep diminishing returns. There isn't any data to find in humans, but the highest dose any human trial has used is 10mcg/kg of bodyweight, which looks like overkill to me.

Do you use the other compound as well? TB-500? Do you have a go to administration protocol for that?

Just like a lot of meds right? More drugs do not always mean more results.
Yes, I've used TB. I dosed as 2.5 mgs twice per week. Many will use 5 mg x 2.
Other compounds would quickly be low dose var and GH or MK (or both GH and MK).