is clomid smart for lowering estrogen?

**amcon** · 10-03-2009, 08:38 PM

is clomid smart for lowering estorgen during a cycle?

example use clomid while on a cycle to lower estrogen levels

**amcon** · 10-03-2009, 08:48 PM

bump

**Big** · 10-03-2009, 09:03 PM

I do not like clomid on cycle.

**amcon** · 10-03-2009, 09:08 PM

Originally Posted by Big

I do not like clomid on cycle.

big love you miss ya too...

can you elaberate why? i have a friend that was asked to take that on a cycle...

why wouldnt you?

**Big** · 10-03-2009, 09:13 PM

if estrogen is a concern I have had much better results using an aromatase inhibitor on cycle, my preference is arimidex at .25mg/eod. if that is not an option and I chose to use a serm nolva at 10mg/day works well for me, but either would only be introduced if the sides call for it. I've tried clomid on cycle and just didn't care for it. someone brighter than me (Swifto for instance) could explain why, I just know from experience what works.

**amcon** · 10-03-2009, 09:14 PM

ok thanx - how you doing

**Big** · 10-03-2009, 09:16 PM

I'm good, could be better but I guess we all could.

**amcon** · 10-03-2009, 09:32 PM

well, i hope your doing great!! if you need any thing let me know... you are a rock star

**Swifto** · 10-06-2009, 01:51 PM

Originally Posted by Big

if estrogen is a concern I have had much better results using an aromatase inhibitor on cycle, my preference is arimidex at .25mg/eod. if that is not an option and I chose to use a serm nolva at 10mg/day works well for me, but either would only be introduced if the sides call for it. I've tried clomid on cycle and just didn't care for it. someone brighter than me (Swifto for instance) could explain why, I just know from experience what works.

Clomid is very active (ER antagonist) in the hypothalamus and there is some data that claims it has weak estrogenic effects at the pituitary. But it still raises LH, FSH and T pretty ****ing well.

It may also down regulate the pituitary to GnRH.

Hayes et al., Aromatase Inhibition in the Human Male Reveals a Hypothalamic Site of Estrogen Feedback,

JCEM Vol. 85, No. 9 3027-3035

The increase in LH pulse amplitude, observed after aromatase inhibition, could potentially reflect an increase in the amplitude of GnRH pulses stimulating the pituitary, and/or enhanced pituitary sensitivity to the same amount of endogenous GnRH. Previous studies have attempted to distinguish between these two mechanisms by examining pituitary responsiveness to pharmacological doses of exogenous GnRH before and during antiestrogen therapy (11, 31, 32). These studies paradoxically demonstrated that clomiphene blunted pituitary responsiveness to exogenous GnRH despite increasing both mean LH levels and the amplitude of spontaneous LH pulses (11, 31, 32). The mechanism proposed for this divergence between spontaneous pulse height and acute pituitary responsiveness to exogenous GnRH was that clomiphene was having tissue-specific mixed agonist/antagonist effects. The authors concluded that clomiphene was acting as an estrogen antagonist at the hypothalamus, resulting in an increase in endogenous GnRH secretion, but as an estrogen agonist at the pituitary, causing decreased responsiveness to exogenous GnRH (11).

This is used in the Clomid vs. Tamox argument. But show me a ****ing study that shows Tamox raised endogenous T by 146% (at 25mg/ED!)....

You cant.