Recent Clomiphene Study on Hypogondal males

[ShakeNbake76]

NEW YORK (Reuters Health) Dec 21 - Clomiphene citrate is a safe and effective treatment for hypogonadism in young men, a new 19-month study shows.

The researchers say this is the longest-term study of clomiphene as a fertility-preserving therapy for men with low testosterone levels , and the largest to look at both objective and subjective responses to treatment.

Dr. John P. Mulhall and colleagues at Memorial Sloan-Kettering Cancer Center in New York City, writing last month in BJU International, note that testosterone -- the standard treatment for hypogonadism -- suppresses secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to testicular atrophy and impaired spermatogenesis.

Clomiphene citrate has been used as an alternative to preserve fertility, but the researchers say there have been few prospective studies of this approach.

Their report focuses on 86 men, average age 29, all with hypogonadism confirmed by two early morning testosterone measurements of less than 300 ng/dL. None of them had been exposed to chemotherapy or pelvic radiation.

Treatment with clomiphene began with 25 mg on alternate days, titrated to 50 mg, with the goal of bringing testosterone levels to between 500 and 600 ng/dL.

During a mean treatment period of 19 months, 70% remained on the 25 mg dose; the rest were on 50 mg. Total testosterone levels went from a mean of 192 ng/dL at baseline to 485 ng/dL, while free testosterone increased from 22 to 95 pg/mL. Estradiol rose from 26 to 39 pg/mL. Both LH and FSH increased significantly as well, from 1.6 to 6.8 IU/mL and from 1.9 to 7.6 IU/mL, respectively.

Based on the androgen deficiency in aging males (ADAM) questionnaire, there were significant improvements in the percentage of men who reported decreased libido (72% to 32%), lack of energy (65% to 40%), decreased life enjoyment (85% to 40%), feeling sad/grumpy (60% to 30%), and decreased sports performance (55% to 25%). Sixty percent of men reported improvement in at least three symptoms, although 10% had no significant improvement in any symptoms.

No serious side effects of clomiphene were observed among the study participants, according to the research team.

The study was not large enough to determine predictors of therapy success or how varicocele status might affect outcome, Dr. Mulhall and his team say. Also, they did not look at how clomiphene affected semen quality.

Nevertheless, they conclude, "Clomiphene citrate therapy has a role to play in the testosterone-deficient man and should be incorporated into the clinician-patient discussion."

[Swifto]

NEW YORK (Reuters Health) Dec 21 - Clomiphene citrate is a safe and effective treatment for hypogonadism in young men, a new 19-month study shows.

The researchers say this is the longest-term study of clomiphene as a fertility-preserving therapy for men with low testosterone levels , and the largest to look at both objective and subjective responses to treatment.

Dr. John P. Mulhall and colleagues at Memorial Sloan-Kettering Cancer Center in New York City, writing last month in BJU International, note that testosterone -- the standard treatment for hypogonadism -- suppresses secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to testicular atrophy and impaired spermatogenesis.

Clomiphene citrate has been used as an alternative to preserve fertility, but the researchers say there have been few prospective studies of this approach.

Their report focuses on 86 men, average age 29, all with hypogonadism confirmed by two early morning testosterone measurements of less than 300 ng/dL. None of them had been exposed to chemotherapy or pelvic radiation.

Treatment with clomiphene began with 25 mg on alternate days, titrated to 50 mg, with the goal of bringing testosterone levels to between 500 and 600 ng/dL.

During a mean treatment period of 19 months, 70% remained on the 25 mg dose; the rest were on 50 mg. Total testosterone levels went from a mean of 192 ng/dL at baseline to 485 ng/dL, while free testosterone increased from 22 to 95 pg/mL. Estradiol rose from 26 to 39 pg/mL. Both LH and FSH increased significantly as well, from 1.6 to 6.8 IU/mL and from 1.9 to 7.6 IU/mL, respectively.

Based on the androgen deficiency in aging males (ADAM) questionnaire, there were significant improvements in the percentage of men who reported decreased libido (72% to 32%), lack of energy (65% to 40%), decreased life enjoyment (85% to 40%), feeling sad/grumpy (60% to 30%), and decreased sports performance (55% to 25%). Sixty percent of men reported improvement in at least three symptoms, although 10% had no significant improvement in any symptoms.

No serious side effects of clomiphene were observed among the study participants, according to the research team.

The study was not large enough to determine predictors of therapy success or how varicocele status might affect outcome, Dr. Mulhall and his team say. Also, they did not look at how clomiphene affected semen quality.

Nevertheless, they conclude, "Clomiphene citrate therapy has a role to play in the testosterone-deficient man and should be incorporated into the clinician-patient discussion."

Excellent piece of information.

Thank-you.

[ShutUpAndRide]

Well it looks like clomid is going to definately come into play for my PCT.

[razorhunter]

How will u guys use clomid? Before or after ur cycle?
Im currently looking for a simple, but of course effective PCT program to use after a basic 12week test-cypionate cycle of about 400mg per week. Any advice appreciated, as clomid is all I can get right now. No nolva source at this time. Thanks for any help.
And thanks for all the info u have posted SWIFTO. It can all be a little mind boggling for a mere beginner like myself tho. I just need some of u guys to help me gain a little PCT confidence!

[Userat204]

Razor as far as pct, I'm sure there is a sticky at the top of the forum but I'll lay out the basic pct.

Serm therapy starts about 2 weeks after last test inject with long esters, enanthate or cypionate .

Clomid is a good choice or torem. You can alwaysadd nolva but clomid and torem are the top two IMO.

Clomid 50mg a day for 4 weeks.
Torem 90,60,60,30

I would add aromisin(exemestane) during your cycle to control estrogen, only if needed, and run it thru pct. Dosing depends on the person but a common dose of aromisin is 6.25mg/day up to 25mg/day but some people require more and some less. Have it on hand in case. It also works well with serms in pct. The goal is to start producing test again, maintain function, so if you begin to have elevated estro you want to reduce that and avoid negative feedback.

Also hcg should be used at 250 iu twice a week during the cycle, and at 500iu a day starting the day after your last test inject for 10 days, take 4 days off and start clomid. Hcg can cause an increase in estro so again have aromisin on hand.

Don't make it overly complicated, it's pretty basic.

[razorhunter]

Thanks UseRat,
Well I must say, wish I had found this forum sooner.
Trusting those in the gym is never good. Of course, when you've known the local gym rats for years, and see their results, you tend to trust them at least somewhat, especially when they were your high school buddies.
The simple fact is they don't know.

I had no idea that clomid, aromisin, AND HCG were all necessary for safe Test cyp cycle!


Hell, when you click on the "Beginner Steroid Cycles" link at the far left menu of this sites home page, you get a huge recommendation to simply run Test Cyp for 12 weeks, (with NOTHING else), and then wait a couple weeks and start your PCT (they recommend Nolvadex )
THAT is why some of us are sitting here in the middle of a cycle without any Clomid, aromisin or HCG.

This has proven very stressful, and has a brother worried about gyno... Now the decision must be made as to either stop two weeks into the cycle, or carry on and just hope for the best, which is never a good thing!
Thanks for your kind help fellas. Very good site here.