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12-17-2018, 12:30 AM #1
Why not Raloxifene on PCT?
I've read it is superior to Nolva so why don't people use it on PCT?
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12-17-2018, 06:26 AM #2
Tamoxifen is known to be better at stimulating natural LH production than Raloxifene.
Raloxifene is known to be better at blocking estrogen binding in the breast tissue than Tamoxifen.
They are both Selective Estrogen Receptor Modulators (SERMs) but their selectiveness and binding affinity differ depending on the tissue. They are both agonists and antagonists for estrogen receptors, which means they upregulate the receptors in some tissue and down regulate it in some other tissue. Also, Raloxifene has higher affinity for estrogen receptors in breast tissue. This is why its better at treating gynecomastia than tamoxifen.
That does not mean that you cannot use raloxifene on PCT. If tamoxifen is not available in where you live, of course you can go for raloxifene.
However, tamoxifen is the optimal solution and from practical perspective, is shown to generate better results.
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^^^^^ This, is exactly true. Tamoxifen and Raloxifene are different, have different binding capacities to different tissues. Depends on what you are trying to do.
So, for PCT Ralox is NOT superior to Tamox.
For Gyno Ralox IS superior to Tamox.
I have the study somewhere showing the Kd of both Tamoxifen and Raloxifene, at the different tissues, or its in one of the books i have... if you really have to know the Kd difference...
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