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  1. #1
    Russianstar is offline Banned
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    Ostarine,Does it work for PCT (Russianstar article)

    Ostarine : Doest it work for PCT?


    Half life 23.8 hours

    Why you need Ostarine (MK2866) in post cycle therapy .

    The first question we need to ask, Is Ostarine suppressive? Since I first suggested the use of Ostarine in PCT over 3 years ago not much has changed. Ostarine is suppressive at certain doses but at the right dose it isnít, it doesnít allow for full recovery at any dose and this is very important, meaning PCT must be carried on after Ostarine is stopped.

    So why use it?

    When a steroid cycle is finished the body is extremely catabolic, with increased cortisol and lowered IGF eating away at your new muscle, Ostarine can prevent the immediate catabolism and allow for enough recovery to prevent this initial muscle loss.

    Ostarine information.

    These were my first experiences with this compound back in 2009.

    Ok firstly some of you may have heard of S4 one of the first sarms available, its the most androgenic version, being 1/3 as much as testosterone on androgen receptors in the muscle. To be honest, its the weakest one of the sarms discovered so far, the Ostarine sARM is much better at promoting lean body mass, its more potent, has a longer half life and displays no androgenic effects, its entirely anabolic .
    Now the dose you may see in studies that showed good lean mass increases was about 3mg-5mg per person, well before i recently started my myo-t12 log i ran MK-2866 or Ostarine for 40 days, being given a sample from a friend, i dosed it at 10mg every day for 3 weeks 15mg for 1 week and 20mg for 1 weeks, and these are the results.
    Weeks 1-3(10mg) ,mass increases +3lbs, round full muscles, and increased strength, not as hard looking as you get with s4, but very good quality, no bloat, no sides, absaloutley no vision problems, The taste is even better than s4Ö not hard to achieve mind you considering s4 tastes like urine with an electric current being passed through it, This weight gain was glycogen retention.
    Week 4 (15mg),+ 2 lbs in 1 week so 5 lbs overall by this stage, no sides, and no increase or decrease in libido like i had with s4, Ostarine showed no effects on the testis in studies, and i would say its not just hype.
    Week 5 + (20mg)2 lbs, i think that 15mg was just as effective, nice lean gains, and some fat loss, though i didnt measure my bmi wich is a shame, i compared s4 with anavar , id say that this is very similar to boldelone, but without any androgen activity, so probably more like primo.
    Now i must admit i had blurry vision a few times during week 5, and a funny tingling in my side, and a little bit of a palpitation, (something i never get) after i had been running, so caution is advised, try a lower dose to check the results.
    The metabolite M1 wich seems to cause toxicity in S4 doesnt seem to be in S1, As i say sides were only seen when using it at a much higher dose, so far its my favourite sarm, no need for regular doses with the 24 hour half life, One other thing i only really noticed after was that i was tired especialy weeks 4 and 5 most of the time, So 10mg seems to be perfect for gains without sides.

    3 Months after this cycle and blood works showing slight suppression and an increase in oestrogen I held on to about 2lbs, but I had a better v taper which showed me that fat loss had been seen, sadly I hadnít done a BMI check before or after.

    My conclusions here

    10mg is the correct amount for PCT , more than that will cause suppression, this enough to allow good recovery and keep hold of your gains.

    If your cycling Ostarine as a solo cycle or stacked my suggestions will be provided below.

    Ostarine, The benefits as compared to Anabolic steroids .
    By now most of you will have heard of sARMS, or selective ANDROGEN RECEPTOR MODULATORS, these new and pioneering supplements bind to the androgen receptor in pretty much the same way anabolic steroids such as Testosterone would, but in a novel and selective way, They exert many of the same anabolic effects that steroids do, but without many of the sides associated with other androgens. The Androgen Receptor plays a vital and significant role in the development and function of sexual organs, skeletal muscle, and bone, as well as other human organs ,When Selective Androgen Receptor Modulators bind to the receptor, they demonstrate powerful anabolic activity in both muscle and bone,(1) This is because they bind to the receptor and change its action in a novel way that is significantly different than typical androgen receptors stimulators such as synthetic androgens and non-synthetic androgens (Steroids) , and so they are able to alter the gene-transcription process in a manner that is tissue specific, in this particular case we are interested in its effects on bone and muscle. Ostarine exerts its effects in a very anabolic way, comparisons have been made with the Anabolic steroid Deca - Durabolin , This is because not only is increased muscle mass seen but it has a very positive effect on joints and bones aswell as nitrogen retention. Now most steroidal androgens convert to DHT or Estrogen so you have the increased chance of DHT related side effects, enlarged prostate for one, and hair loss if your prone, as well as a whole list of other potential DHT related side effects. And Estrogen causes a whole host too, Water retention (Edema), Hypertension (High blood pressure) and the unwelcomed and often hard to treat enlargement of the male breast tissue (Gyno)(2). You also get your own testosterone production shutdown on cycle so a Post cycle therapy protocol is essential to restore correct testosterone levels , even then the ongoing effects of impotence can be seen for many months after full testosterone recovery has been achieved. However those problems along with many others if the steroid of choice is a progestin, can to some degree be eradicated through science, and the development of these new sARMS.
    Ostarine (OSTA-SARMS) Doesnt convert to DHT or display any of the side effects by Dihydrotestosterone. In blood tests a slight raise in estrogen levels can be seen, and that might be one of the key factors in its tremendous potential for treating tendon, ligament, and bone injuries or illnesses. It also displays a very anabolic effect on muscle tissue, causing considerbale and easy to maintain gains in muscle over 4-6 weeks, with little to no sides and no real PCT is needed afterwards, just a mild test booster like DAA.

    Another interesting aspect as opposed to your typical steroid is that sARMS remain very hard to detect for Anti-doping agencys as sARMS bypass in effect the well known 4 ring steroid structure, so they are not steroids, but yet sARMS exert many of the same performance enhancing effects that steroids do without the sides (3)
    Ostarine, Unleashing its power.
    The big question is how do you get the most bang for your buck from Osta-sarms/ MK-2866? Firstly we need to get some facts straight on what it is exactly, its half life and best dose. Ostarine has a half life of 23.8 hours, So a once a day dose is the most effective to get your biggest peak of blood plasma serum levels. Depending on your goals though there are a couple of doses i personaly would recommend.
    Anabolic dosing.
    Dosing at 24mg-36mg a day gave me my biggest gains in muscle and the best muscle pumps over a 4 week period, going higher than 36mg did not increase the gains in lbm or strength over the same period, for somone weighing 200lbs 24mg is enough to elicit very good anabolism, However for somone weighing above 210lbs, 36mg in experiments i carried out seemed to be a much better dose and offer better general lbm gain, with this dose muscle hardness can be seen to increase after about 6 days.

    I suggest front loading Ostarine the first week, Close to double your intended dose, this will speed up the saturation of ostarine in the system and its affect on the androgen receptor.
    These very same doses can be used on a cut, with decreased calories to maintain muscle, I highle recommend the use of Osta-sarms in this regard as even in a calorie surplus diet fat loss can be lost at quite a high rate 1-2lb a week, on a cut with added stimulants the loss of viceral fat can be increased exponentialy and muscle tone and hardness will also increase at a rapid rate revealing a ripped and cut physique thats also in a lot better state health wise than if a steroid was used to increase muscle retention during the same period of time.
    Bone and tendon repair dosing. One of the outstanding facets of Ostarine is that it doesnt just build muscle, it increases tendon strength, improves the health of the ligaments, increases bone density and increases the rate at wich collagen is turned over. To achieve this a dose of 12mg ed is adequate, and promotes improvement in joint movement that can be seen after just 6-8 days, this dose is very effective for treating injuries like shin splints, and can be used post operation to help maintain muscle and speed up the recovery of the limb, (Bone/Tendon) that has been operated on.
    Supplementation while using sARMS.
    My favourite supplements wich seem to increase the effectivness of Ostarine are Creatine wich itself increases igf-1 levels,bone density, Lean body mass, and prevents the release of homocysteine thus preventing cardiovascular problems. Zinc and magnesium are a must as both are vital for increase in testosterone levels, androgen receptor sensitivity, and igf-1 levels to remain at a maximal level.

    Ostarine in PCT summary.

    Remember that you will not fully recover while using Ostarine even at the suggested dose of 10mg a day, which is enough to provide much needed anabolism while allowing recovery, Stopping Ostarine and continuing your pct for a couple of weeks is essential to ensure total recovery from your steroid cycle.

    Combining Ostarine with a sERM, and an anti-estrogen , Aromasin or Formestane being my suggestions would be best.

    In my next article we will look at the Perfect post cycle therapy with sARMís

    1.Selective androgen receptor modulators in preclinical and clinical development.
    Narayanan R, Mohler ML, Bohl CE, Miller DD, Dalton JT. Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, USA
    2.J Steroid Biochem Mol Biol. 2006 Dec;102(1-5):261-6.Prostate cancer risk in testosterone-treated men. Raynaud JP. Université Pierre & Marie Curie, 51 bvd Suchet, Paris 75016, France. 3.Bioorg Med Chem Lett. 2008 Oct 15;18(20):5567-70. Epub 2008 Sep 5.Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators. Bohl CE, Wu Z, Chen J, Mohler ML, Yang J, Hwang DJ, Mustafa S, Miller DD, Bell CE, Dalton JT. Division of Pharmaceutics, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, 242 L.M. Parks Hall, Columbus, OH 43210, USA

    Kindest regards R.s

  2. #2
    AR's King Silabolin's Avatar
    AR's King Silabolin is online now Castle Power
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    May 2015
    as a bridge beetween cycle and pct....wanna try

  3. #3
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    Ostarine is proven to surpress testosterone down so i don't think it would be a wise option for pct

  4. #4
    Juced_porkchop's Avatar
    Juced_porkchop is offline Knowledgeable Member
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    Jul 2012
    suppression is suppression whether small or big I think its a bad idea to use in PCT personally.
    I would rec peptides in PCT, they could help hold mucle and even help pct. Id toss in igf1, ghrp, mod grf as a combo or solo over any sort of sarm IMO

  5. #5
    jimmyinkedup's Avatar
    jimmyinkedup is offline Disappointment* Known SCAMMER - Do Not Trust *
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    I agree any suppression at all is bad in pct so I dont think it has a place in pct at all. The guys above are spot on IMO.
    Last edited by jimmyinkedup; 07-28-2015 at 08:58 AM.

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