I have read a few threads about people using letrozole to reverse gyno, by applying it to their nipples, along with taking it orally. Applying it directly to your nipples seem pretty pointless to me. Does any one have any medical studies to back this practice up? I agree letrozole is a great drug to use in both treating gyno and breast cancer, but to rub it on your skin seems like a waste to me. Have doctors been treating breast cancer this way lately, and if so where is the literature to back this practice up?