I came across some potentially concerning information and don't know quite how to view it. There's literature out there indicating nsaids will exacerbate arthritis and inhibit cartilage repair (see for example, http://journalofprolotherapy.caringm..._10_nsaids.pdf).

This came as a bit of a shock to me as I have disclosed my usage of 1600-2400 mg ibuprofen/day to treat joint inflammation/pain to both my primary care physician and various specialists I've worked with on my various joint issues. In these discussions, i had been informed about the risks of stomach bleeding and advised not to go over 2400 mg/day to avoid, but the risk to cartilage and arthritis had not been mentioned.

I appreciate any thoughts anyone has on this issue. Perhaps the simplest questions are:

Will 1600-2400 mg ibuprofin/day meaningfully/signficantly increase loss of cartilage or arthritis progression (for my severe traumatic arthritis)?

Will a lower amount or different nsaid provide a better risk/reward profile for managing joint inflammation/pain?

Are there alternative treatments I should consider for managing joint inflammation/pain?