
Originally Posted by
einstein1905
As you grow, you're increasing cell-count of muscle fibers. You do this indirectly or directly. AAS increase GH and IGF-1, which increase cell count of muscle fibers, or using GH or IGF-1 directly can lead to this as well. resistance training itself increases GH and IGF-1 too. The result of it all is a higher cell-count of muscle fibers. Not only does this allow for greater muscular size but also for an increased number of potential androgen receptors ( I won't go into up and down regulation of receptors). The increased number of receptors won't be a negative thing, even at normal androgen levels, this will actually increase the probability of androgen:AR bindings (you have a room full of flies and ten fly traps...you add ten more fly traps without increasing the number of flies, you catch more flies).
As for "genetic limitations", it certainly does exist, but we have no idea where this is. We use this phrase only in the context of what we currently know about hypertrophy and methods of increasing it. "genetic limitations" haven't changed over 20 years, but our knowledge of nutrition and training has, and this has allowed us to be able to attain more mass (naturally or otherwise). there's no reason to believe that over the next 20 years we won't learn even more about how the body works and find ways to better optimize training and nutrition....I say this independent of exogenous androgen use.
When people say, "don't use AAS until you've reached your genetic potential", they actual mean to wait until you've reached an obvious plateau and have utilized as many of the modern methods as possible to induce more natural growth.