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Thread: HGH Usage - A Different View

  1. #1
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    HGH Usage - A Different View

    Guys I came across this post when I was doing some research. I am particlarly interested in your comments on this guys statement that the 5 on 2 off protocol is not a good idea.


    According to studies in the New England Journal of Medicine GH use will:
    Shed Bodyfat, Increase Muscle Tone; Boost your Energy, Strength, and Endurance
    Reduce Wrinkles and Create Tighter, Smoother Skin; Help you Sleep Better, Improve Sex Drive and Performance, Improve Immune and Heart Function, Bone Density, Healing Time and Cholesterol, Improve Brain Function, Memory and Mental Focus

    Wow! Sure sounds like a wonder drug to me! Yeah right, anyway here is some real world information for bodybuilders. Somatropin (rHGH) is produced by the pituitary gland and is responsible in adolescence for growth of tissues, protein deposition, and the breakdown of sub-q fat stores. As we age, growth hormone levels decrease but still remain active in the body, releasing in cycles during the day. Synthetic growth hormone used exogenously by bodybuilders is a 191 chain sequence of amino acids that replicates the bodies natural production of growth hormone.

    Growth hormone has been in use by bodybuilders since the early 1980’s, though at this time, HGH was being extracted from the pituitary glands of cadavers and had enormous side effects, most prominently Creutzfeldt Jacob disease. This is a rare and fatal brain disease, it need not be discussed here since it is not possible in synthetic forms of rHGH, but if you want more info just run a search in google. rHGH stimulates growth in most body tissues which is due to an increase in cell number rather than cell size. This includes muscle tissue as well as internal organs, hence the dreaded GH gut.

    Use of growth hormone by bodybuilders will cause increased muscle size, localized and overall bodyfat loss, increased protein synthesis, increased glucose output by the liver, increased insulin resistance and lowered thyroid output. Stored fats will be used as a primary fuel source, thus the body fat loss.

    So is rHGH the wonder drug everyone lusts after? It certainly is beneficial but not for everyone. You must be willing to take risks to achieve maximum benefits from its use, as well as substantial financial investment. Do it right the first time or don’t do it at all! You will achieve faster and greater growth from cycles of steroids than with GH, though once you reach a plateau, not many products work better.

    Ok, so now you have decided that this is the drug for you and you are ready to try it, so what next? Well here are some general guidelines to follow for maximal results from GH use:

    Daily injections are a must to maintain stable blood levels as GH has a very short life span in the body. It will peak almost immediately after injection and will clear the body with a half-life of only 20-30 minutes. It is best injected first thing in the morning upon rising to raise levels that are very low from sleeping, and immediately after training. I do not recommend injecting before bed as many bodybuilders do, since that is the time of day that your body will release naturally high levels of growth hormone, and exogenous use will only block that release. If you take it in the morning when levels are low, after training when levels are depleted and then let your body release while sleeping, you are getting one extra release for free! GH is best taken long term, short cycles do not maximize the benefits of muscle cell increase, only fat loss. Here is how I take my GH for maximum benefits:

    6iu ed injected sub-q, preferably in the stomach
    3iu injected upon rising, 3iu injected immediately post-workout
    10iu insulin taken 30 minutes after GH injection
    25mcg cytomel ed
    use of androgens such as testosterone

    The timing of GH and insulin injections is critical. If insulin is injected before the GH, your pancreas will stop release of insulin monitoring due to the exogenous source. GH when injected will mobilize stored glycogen release which will turn into glucose for energy. This will cause a rapid rise in blood sugar levels that will not shut down or stop rising due to the feedback loop being momentarily cut off. You will go hyperglycemic and end up in the hospital. You must first inject your GH, then the insulin; this will cause a rise in glucose release by the GH and will be controlled and shuttled into muscle tissue for repair by the later injection of insulin.
    Use of cytomel or some type of T3 hormone is critical since GH use will severely lower thyroid levels. Small exogenous sources are necessary to maintain normal levels and 25 mcg ed is sufficient. This will also aid in body fat loss by maintaining proper thyroid functioning.
    Use of androgens is also necessary due to the promotion of anabolism by increasing muscle size that benefits the new cell number increase by the GH. Remember GH will not directly cause muscle cell size increase, just the number of cells, therefore, androgens are necessary to increase size. Testosterone or trenbolone are both highly androgenic and perfect for out stack.

    One myth that needs to be cleared up: high doses of GH use and the 5 on 2 off program. First, if you find that you are not achieving results off of 4-6iu ed, than something else is the problem, not your dose. The use of high doses if primarily cause by heat damage to the protein chain causing denatured proteins. This will decrease the effect and you must use higher doses to achieve the same effect. Other reasons for high dose use are; fake gh, not using insulin, cytomel or test, poor diet, improper timing schedule and the 5 on 2 off. This program was recommended by dealers as a way to move product by offering a lower cost cycle. No doctor in the world would recommend this protocol, Peak blood concentrations are reached in 2-6 hours after injection, and therefore, multiple daily injections are necessary to achieve stable release schedule and results. If you take your last injection Friday afternoon, and then not again till Monday morning, then you have negated all effects offered by the 6 hour concentration. Yes, you will achieve results using a 5 on 2 off program, but not as well as if you inject ed. It’s your money; I can only tell you how to optimize use.

    Side effects of GH use include; carpal tunnel syndrome, tingling in the extremities, numbness in the hands and feet, increased organ growth, decreased insulin reception, acr*****ly but only in extreme dose use, and decreased thyroid output causing fat accumulation. If you find that you are experiencing any of the above side effects, lower your dose immediately. This is especially important with carpal tunnel. If you feel like your wrists are hurting then lower the dose until pain subsides. You do not want to have that surgery, trust me.

    GH is a fantastic product, beneficial for many reasons. Most people will experience thinning of the skin, increased vascularity, fat loss, permanent increases in muscle size due to the cell number increase, and overall feelings of wellness. You will probably need less sleep and feel supercharged all day long. I highly recommend GH use, but only when you have the money to do it right. 4-6 month cycles are optimal, year round if you are over age 35. If you have anything of benefit to add to this thread, feel free to contribute or PM me. "

  2. #2
    I often feel that the 5/2 protocl is false economy and it would be better to lower the average dose over a 7 day period rather than opt for the 5/2, this is if money is an issue,if it isnt then run it at what you would on a 5/2. In order to find out if there is any difference in the results i feel the only way would be to try both ways for yourself,and others such as eod. 7/7 is the only way i havnt tried actually and in order to conclude if it is in fact the best way then i think i will give it a go.

  3. #3
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    Quote Originally Posted by xtralarg
    I often feel that the 5/2 protocl is false economy and it would be better to lower the average dose over a 7 day period rather than opt for the 5/2, this is if money is an issue,if it isnt then run it at what you would on a 5/2. In order to find out if there is any difference in the results i feel the only way would be to try both ways for yourself,and others such as eod. 7/7 is the only way i havnt tried actually and in order to conclude if it is in fact the best way then i think i will give it a go.
    Thats what I am thinking as well

  4. #4
    Quote Originally Posted by Kale
    Thats what I am thinking as well
    Its just the cost i dont like! It seems a shame to be doing 5/2 if 7/7 is so much better though, it would feel like ive been wasting my time!

  5. #5
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    Quote Originally Posted by xtralarg
    Its just the cost i dont like! It seems a shame to be doing 5/2 if 7/7 is so much better though, it would feel like ive been wasting my time!
    Yeah cost would be worse for you than me though. I plan on getting to only 6 IU's a day and staying there forever.

  6. #6
    Quote Originally Posted by Kale
    Yeah cost would be worse for you than me though. I plan on getting to only 6 IU's a day and staying there forever.
    It would,im doing 10..i think i will have to re-evaluate things if im going to do 7/7 for a long period and lower the dose slightly,either that or sell my body to pay for it!

  7. #7
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    Quote Originally Posted by xtralarg
    It would,im doing 10..i think i will have to re-evaluate things if im going to do 7/7 for a long period and lower the dose slightly,either that or sell my body to pay for it!
    Only money you will be getting as if you sell it as a cadavar !!!!

  8. #8
    Quote Originally Posted by Kale
    Only money you will be getting as if you sell it as a cadavar !!!!
    LOL....your absolutly correct!!!!!!!

  9. #9
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    Excellent post.

  10. #10
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    I'm just sceptical of guidace that is full of declarative statements, with no studies to back them up. This one is reasonably logical, but sadly it lacks support/evidence for the advice given.

  11. #11
    Quote Originally Posted by Triposinator
    I'm just sceptical of guidace that is full of declarative statements, with no studies to back them up. This one is reasonably logical, but sadly it lacks support/evidence for the advice given.
    Even studies with studies backing them up are sometimes inaccurate though, a doctor once told me that nothing in medicine is black and white. My philosophy is to try it for yourself because everybody reacts differently.

  12. #12
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    Agreed, be smart, try it, just don't confuse it with science.

    I run hgh 7 days a week.

    Quote Originally Posted by xtralarg
    Even studies with studies backing them up are sometimes inaccurate though, a doctor once told me that nothing in medicine is black and white. My philosophy is to try it for yourself because everybody reacts differently.

  13. #13
    Quote Originally Posted by Triposinator
    Agreed, be smart, try it, just don't confuse it with science.

    I run hgh 7 days a week.

    Have you ever ran it any other way? If so whats your opinion?

  14. #14
    Interesting, and while it is true that the medical research on this stuff can be somewhat sketchy and sometimes inconclusive (esp. wrt BB, as most research does not directly relate) we can out and out refute the assertions that 5/2 is a "dealer" thing with references in our own library:

    There was a study done on continuous GH use vs. every other day injections (ED vs. EOD for the sake of brevity), with a equal total weekly dose. Although it’s counterintuitive, every other day injections produced better total growth in the kids in this (2 and 4 year long) study.Shooting GH every other day more accurately replicates the pulsile frequency of GH, and thus gave better results for growth (height) deficient children… GH pulsatility is necessary for proper function of the GH receptor.(10) Dosing in the EOD nature reduces incidence of any sort of withdrawal problems associated with normal GH use, including regression or retardation of growth after cessation of therapy.(10)

    10. The Journal of Clinical Endocrinology & Metabolism Vol. 87, No.8 3573-3577

    So, good reasoning backed by medical literature. Of course as has often been pointed out, this is in children and perhaps for adults, particularly over 35 with relatively very low GH production, perhaps those results are not so applicable simply because they simply have less natural production to be interfered with. The burn/AIDs/surgery type literature tends to follow ED protocols. Also, if you are committed to lifelong/multi year HGH use then EOD may matter less - the EOD protocol followed the children after they had discontinued use. Which are we most like? Good question.


    Another of his points, the simple declarative statement that 6IU is the maximum dosage seems dubious if only simply because we know that GH is dosed by BW, and unless he has done some comprehensive study including individuals over 400+ pounds we can't take his assertion seriously. At best this is perhaps anecdotal evidence from the author that in his experience he no longer sees benefits above 6IU. Interesting feedback, but hardly words to live by - particularly not knowing who he is, his size, training, etc.


    The literature specifically relevant to athletes also refutes his 6IU premise. One of the refences in our library, which I sought out and read the full article - High dose growth hormone exerts an anabolic effect at rest and during exercise in endurance-trained athletes.J Clin Endocrinol Metab. 2003 Nov;88(11):5221-6. - used 0.067 IU/KG, or 6.7IU for a 220lb man (anyone here bigger than that - though in the study none were over about 81KG) . Get this - they saw substantial results, mostly metabolic of the kind you could not see, but can be measured - in 2 weeks and as much as a 6% increase in LBM within 4 weeks. And yes, their protocol was ED, sq, at night.

    I think most of what that author in the original post says is not controversial, but his controversial statements seem to be problematic simply because (as Trip pointed out) they are declarative statements without evidence, and fly in the face of some reasonably good research - not the "word of a dealer" (which, by the way, makes little sense if you think about it anyway) or because it is bad stuff.

  15. #15
    Oh, and I almost forgot - 5/2 is the probably the most commonly prescribed schedule for anti-aging clinics, including discussions at the A4M, so his notion that "No doctor in the world would recommend this protocol" is simply nuts, as they do so every day of the week!

  16. #16
    Quote Originally Posted by vermin
    Oh, and I almost forgot - 5/2 is the probably the most commonly prescribed schedule for anti-aging clinics, including discussions at the A4M, so his notion that "No doctor in the world would recommend this protocol" is simply nuts, as they do so every day of the week!
    Agreed!

  17. #17
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    No sir, only 7 days a week, 2 shots a day.

    Quote Originally Posted by xtralarg
    Have you ever ran it any other way? If so whats your opinion?

  18. #18
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    Oink!

  19. #19
    Trip, how many out of 12 months in the year do you run it?

  20. #20
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    I've only been running it 17 +/- weeks. My 1st run of hgh. I have enough to last 9 months. I'm going to give it that long, then decide what next.

    I've got a thread/log going on my cycle here in this forum here is link

    http://forums.anabolicreview.com/sho...d.php?t=249691

    Its a "pure hgh log" nothing else.

    Quote Originally Posted by vermin
    Trip, how many out of 12 months in the year do you run it?
    Last edited by Triposinator; 07-24-2006 at 06:45 PM.

  21. #21
    Have you thought about how long you'd stay off to balance 9 months ed, or are you thinking you might keep going?

  22. #22
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    information overload, one post says use t3 another says t4.

  23. #23
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    I've thought about it, just haven't figured it out yet.

    My travel schedule forces a few days off (2-3) like once a month.


    Quote Originally Posted by vermin
    Have you thought about how long you'd stay off to balance 9 months ed, or are you thinking you might keep going?

  24. #24
    What made you decide to run it that way? I am sure that 7/365 the results are best, but that could be deciding to run it for the rest of my life and that's a hard commitment to make.

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