
Originally Posted by
GearHeaded
it does not get ''immune'' as Test is a natural male hormone needed for many functions in the body. however if your blasting Test at supra-physiological dosages then after a period of time your body is going to up-regulate Myostatin (Myostatin is a catabolic hormone that prevents your body from putting on un-neccessary muscle mass).
So basically Myostatin is going to counter the muscle building effects of Test and your going to get to a point where its difficult to put on any more size . This is where you need to either get off of Test for awhile, or introduce new anabolic growth factors to the body that do NOT up-regulate Myostatin , like HGH, IGF, Insulin (your body can continue growing without an increase of Myostatin) . Or, you need to introduce other Anabolics that work though slightly different mechanisms of action , like Tren for example will increase IGF1 production.
imo , its best to not stay at a high dose of test year round . Myostatin will just be up-regulated year round and your not going to grow (unless your a newb and your getting those first cycle newb gains ,, but after a few years of being on gear and training, 500mg a week of test isn't going to do much for you as far as growth, its just going to allow you to maintain).
so either come off for 6+ weeks and down regulate Myostatn and re-sensitize, or learn to stack other compounds and growth factors to illicit more gains