ORIGINALLY POSTED BY SUPERCHICKEN, stolen by tony touch from crankenstein, and pilfered by BASK8KACE
There has been a lot of talk on other boards about this lately, and a lot of bad information thrown out as well. I wanted to share the good info.
Somone keeps posting how letrozole is the strongest and doesnt negatively affect cholesterol. This is not true. Letrozole is NOT the strongest and it DOES affect cholesterol/lipid profile negatively.
Aromasin (Exemestane) is the best. This is why:
Both Arimidex/Ldex/Anastrozole and Femara/Letrozole hurt your cholesterol. The way these 2 anti e's work is they inhibit the aromatase enzyme. By inhibiting the enzyme which converts testosterone to estrogen, you reduce or even come close to eliminating estrogen production. We need some estrogen to be healthy. The major drawback to this is without estrogen, your lipid profile gets F***ed.
Aromasin (Exemestane) works differently. It does not stop the body from producing estrogen. Rather, it makes it so the estrogen is unable to bind to receptors by deactivating the binding enzyme. If the estrogen cannot bind, you simply will not get bloated or get gyno. The estrogen is crippled due to exemestane. However, since the estrogen is still floating around, it will not negatively affect your lipid/cholesterol profile.
Anastrozole (Arimidex) doesnt cause a rebound effect, and neither does exemestane, but letrozole does. This means after you stop the letrozole, your estrogen rebounds and goes pretty high for a while, eventually it normalizes. You can avoid this by tapering your letro dose down before stopping it, but that is a pain in the ass. Higher than normal can mess many things up post cycle when you stop. Since the HPTA has a feedback loop is primarily controlled by estrogen, high estrogen will tell your HPTA to produce less testosterone, because it thinks the high estrogen is caused by too much testosterone. This is fact. Now post cycle, dont we want to raise our test levels, not lower them? Of course! So, rebounds are bad. If you use letro taper the dose off to zero over a couple weeks.
FYI- Nolvadex(Tamoxifen) is a SERM(Selective Estrogen Receptor Modulator). This means on certain tissue it can act antagonisticaly or agonistically. In the case of lipid profiles, It acts agonistically. So, running tamoxifen with your anti e's will IMPROVE your cholesterol profile even if not on cycle or using any gear or other anti e's. It's just plain good for cholesterol.
One thing to keep in mind though when runing tamoxifen with letro is that letro reduces blood levels of tamoxifen by over 50%. a study showed 2.5mg letro ED made nolva levels drop to 40% of what they were before adding letro. This does not mean you cant use tamoxifen with letro, it just means you need to use more, about double. In other words, 20mg of nolva will act like 8mg if running letro. So, make sure you are aware of this because you will need to buy more nolva to compensate. This does not happen when mixing tamoxifen with anastrozole or exemestane, it only hppens with letro.
NOTE: After this was posted, Pheedno mentioned the following which has been placed here to shed light on this possible mistake made by the original author of this postNolva in full clinical doses(20mgED) reduces letro plasma levels by 37.6%(Not the other way around at 50%). Nolva in full clinical doses reduces anastrozol plasma levels by 27%.
Also, many people experince a reduction of libido on letro. This doesnt happen w/ ldex or exmestane as far as I know, and in my own experience, and I've run all 3 quite a bit.
The best combo is exemestane and tamoxifen together. Your cholesterol will be as good as can be considering your on a cycle of steroids. The dose of aromasin will vary depending on the users needs and how much aromatizing gear is being taken. Usually 10-25mg ed works well. Run 10mg ed nolva to improve your cholesterol.
Second best combo i feel is anastrozole(Ldex, Arimidex) and tamoxifen. Ldex dose ranges from usually .15mg ed to 1mg ed. run 10mg nolva ed to improve cholesterol.
Third best is letro and nolvadex. Letro doses usually range from 1-2.5mg ed. run 20mg ed nolva to improve cholesterol w/ letro.
You do not need to run nolva with any of these 3, i do recomend it though as it will improve cholesterol compared to using the anti e's alone without nolva.
So, in order of strength, on a dose per dose basis(not mg per mg) aromasin is def the strognest, next is letro, and then ldex.
I've been running aromasin now for about 4 months, I wont switch back to ldex or letro. It works much better and it's much healthier for cholesterol profiles.
I think we all need to stop only worrying about side effects that we can see visually. Cholesterol KILLS many people around the world everyday(well not directly kills but leads to it). steroids are hUrting us badly in this sense. steroids do mess our cholesterol up pretty badly, and we will pay for it later in life. Now not many of us are going to stop using gear because of that, but we should at least take the proper other drugs to help minimize.
Aromasin is only a little bit more expensive than ldex or letro, and its actually about the same price as many places sell ldex or letro for. But it's more powerful and healthier. People spend money all the time on steroids which dont have as many side effects as some of the harsher, cheaper steroids. A few extra bucks for the proper anti e's is def money well spent.
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